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61 results for “Brachyury”
Human T-box transcription factor T (Brachyury); A Target Enabling Package
<p>Chordoma is a rare cancer occurring along the spinal cord (OMIM: <a href="https://www.omim.org/entry/215400">215400</a>). Chordoma is derived from an embryonic tissue, the notochord, and over-expresses the embryonic transcription factor T-box transcription factor T, the homologue of mouse Brachyury. Chordomas are “genomicaly silent” cancers that do not carry an extensive mutation load. Recent studies indicate that expression of TBXT is essential for persistence and growth of chordoma cells. As TBXT is not expressed in any post-embryonic tissues, it could be an excellent target for treatment of chordoma. The long-term aim of this project is to test whether TBXT can be targeted with small molecules with sufficient affinity and specificity to be therapeutically useful. In this TEP we have determined crystal structures of the DNA-binding domain (DBD) of TBXT with and without cognate DNA oligonucleotides. The DNA-free protein crystals were used in a high-throughput fragment screen to identify 29 fragments bound in 6 clusters. The crystal structures of the bound fragments provide starting points for development of stronger binders which could be used to disrupt TBXT activity or to induce the degradation of the protein through a Proteolysis-targeting chimeric molecule (PROTAC) approach.</p>
M. brachyuris var. sigmaturoides n in Niederrheinisctie freilebende Nematoden.
M. brachyuris var. sigmaturoides n. var.
Fig. 5. M. brachyuris var. sigmaturoides. 1 in Niederrheinisctie freilebende Nematoden.
Fig. 5. M. brachyuris var. sigmaturoides. 1/12 Fl.
Safety and Tolerability of a Modified Vaccinia Ankara (MVA)-Based Vaccine Modified to Express Brachyury and T-cell Costimulatory Molecules (MVA-Brachyury-TRICOM)
ClinicalTrials.gov study NCT02179515. IPD Sharing: NO. Countries: 1. Publications: 4.
Cancer Vaccine Targeting Brachyury Protein in Tumors
ClinicalTrials.gov study NCT01519817. IPD Sharing: NO. Countries: 1. Publications: 5.
QUILT-3.011 Phase 2 Yeast-Brachyury Vaccine Chordoma
ClinicalTrials.gov study NCT02383498. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat (QuEST1)
ClinicalTrials.gov study NCT03493945. IPD Sharing: YES. Countries: 1. Publications: 2.
BN Brachyury and Radiation in Chordoma
ClinicalTrials.gov study NCT03595228. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Tolerability Trial (MVA-BN-Brachyury/FPV-Brachyury)
ClinicalTrials.gov study NCT03349983. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 1 Open Label Trial of Intravenous Administration of MVA-BN-Brachyury Vaccine in Patients With Advanced Cancer
ClinicalTrials.gov study NCT04134312. IPD Sharing: NO. Countries: 1. Publications: 2.
TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer
ClinicalTrials.gov study NCT04246671. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Transcriptomic evidence for Brachyury expression in the caudal tip region of adult Ptychodera flava (Hemichordata)
<p>Most metazoans have a single-copy of the T-box transcription factor gene,<em> Brachyury</em>. The gene is expressed in cells of the blastopore of late blastulae and the archenteron invagination and stomodeum invagination regions of gastrulae. It appears to be crucial for gastrulation and mesoderm differentiation of embryos. Although this expression pattern is shared by most deuterostomes<a href="#_msocom_1">[AA1]</a> , <em>Brachyury</em> expression was not reported in adult stage. Here we show that <em>Brachyury</em> of an indirect-developer, a hemichordate acorn-worm, <em>Ptychodera flava,</em> is expressed not only in embryonic cells but also in cells of the caudal tip (anus) region of adults. This spatially restricted expression shown by whole-mount <em>in situ</em> hybridization was confirmed by Iso-seq RNA sequencing analyses and single cell RNA-seq (scRNA-seq) analysis. Iso-seq analysis showed that the gene expression occurred only in the caudal region of the adult but not in the anterior regions including stomochord. scRNA-seq analysis showed that a cluster that contained <em>Brachyury</em>-expressing cells composed of mesoderm-related cells, but not associated with epidermis, nervous system, and muscle. Although further studies are required to examine roles of <em>Brachyury</em> at the adult stage, this study suggests a possible evolutionary link of the <em>Brachyury</em>-expressing caudal tip of hemichordates with the anus formation region of chordates.</p>
BN-Brachyury, Entinostat, Adotrastuzumab Emtansine and M7824 in Advanced Stage Breast Cancer (BrEAsT)
ClinicalTrials.gov study NCT04296942. IPD Sharing: NO. Countries: 1. Publications: 0.
Ectopic expression of the Brachyury transcription factor upregulates only a subset of notochord expressed genes
GEO Series GSE102142. Ciona intestinalis. 6 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death [RNA-Seq II]
GEO Series GSE120210. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Targets of the transcription factor Brachyury in differentiating mouse ES cells
GEO Series GSE16646. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by genome tiling array.
The molecular basis of specific functions of Brachyury and Eomes for mesoderm and endoderm lineage specification
GEO Series GSE194192. Mus musculus. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
High-resolution Brachyury DNA-binding Sites Mapping by ChIP-exo
GEO Series GSE54963. Mus musculus. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide identification of notochord enhancers comprising the regulatory landscape of the Brachyury (T) locus in mouse
GEO Series GSE235030. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
gene profiling changes induced by regulation of Brachyury expression
GEO Series GSE103716. Homo sapiens. 7 samples. Type: Expression profiling by array.
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