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ShareScore release 0.9.0
Dataset results
8 results for “Brain vascular injury”
Effects of Erythropoietin on Cerebral Vascular Dysfunction and Anemia in Traumatic Brain Injury
ClinicalTrials.gov study NCT00313716. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Antimicrobial immunity impedes CNS vascular repair following brain injury
GEO Series GSE172102. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Pericytes exhibit a parallel pro-fibrotic response after vascular injury in the heart and brain
GEO Series GSE178469. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Data from: Sleep disordered breathing is associated with brain vascular reactivity in spinal cord injury
Objective: Our goal was to determine the population-level odds of individuals with SCI experiencing fatigue and sleep apnea, to elucidate relationships with level and severity of injury, and to examine associations with abnormal cerebrovascular responsiveness. Methods: We used population-level data, meta-analyses, and primary physiological assessments to provide a large-scale integrated assessment of sleep-related complications after SCI. Population-level and meta-analyses included more than 60,000 able-bodied individuals and more than 1,800 individuals with SCI. Physiological assessments were completed on a homogenous sample of individuals with cervical SCI, and matched controls. We examined the prevalence of 1) self-reported chronic fatigue, 2) clinically-identified sleep apnea, and 3) cerebrovascular responsiveness to changing CO2. Results: Logistic regression revealed a 7-fold elevated odds of chronic fatigue after SCI [OR: 7.9, 95% CI: 3.5-16.2], and that fatigue and trouble sleeping are correlated with the level and severity of injury. We further show that those with SCI experience elevated risk of clinically-defined sleep-disordered breathing in more than 600 individuals with SCI [pooled OR: 3.1, 95% CI: 1.3-7.5]. We confirmed that individuals with SCI experience a high rate of clinically-defined sleep-apnea using primary polysomnography assessments. We then provide evidence using syndromic analysis that sleep-disordered breathing is a factor strongly associated with impaired cerebrovascular responsiveness to CO2 in patients with SCI. Conclusions: Individuals with SCI have an increased prevalence of sleep-disordered breathing, which may partially underpin their increased risk of stroke. There is thus a need to integrate sleep-related breathing examinations into routine care for individuals with SCI.
Impact of Severe Brain Injury on Neuro-vascular and Endothelial Regulation of Peripheral Microcirculation.
ClinicalTrials.gov study NCT04597879. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After Stroke
ClinicalTrials.gov study NCT04588649. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Sleep disordered breathing is associated with brain vascular reactivity in spinal cord injury
Open the record for dataset details and reuse information.
Evaluation of therapeutic efficacy of Sodium thiosulfate in combating I/R injury in rat brain: Exploring its efficiency further in vascular calcified brain slice model
<p>Cerebral ischemia reperfusion injury (CIR) is one of the clinical manifestations encountered during the management of stroke. High prevalence of intracranial arterial calcification is reported in stroke patients. However, the impact of vascular calcification (VC) in the outcome of CIR and therapeutic interventions remains unclear. Two different experimental models namely carotid artery occlusion and brain slice models were used to evaluate the efficacy of STS in male Wistar rats. IR was inflicted in rat by occluding carotid artery for 30 minutes followed by 24 hr reperfusion after STS (100 mg/kg) administration. Brain slice model was used to reconfirm the results to account blood brain barrier permeability. Further, brain slice tissue was utilised to evaluate the efficacy of STS in VC rat brain by measuring the histological alterations and biochemical parameters.</p> <p> </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.