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32 results for “Bronchoalveolar lavage fluid”
Data for manuscript, "An optimized workflow for MS-based quantitative proteomics of challenging clinical bronchoalveolar lavage fluid (BALF) samples"
<p>Clinical BALF samples are rich in biomolecules, including proteins, and useful for molecular studies of lung health and disease. However, MS based proteomic analysis of BALF is impeded by the dynamic range of protein abundance, and potential for interfering contaminants. We have developed a workflow that eliminates these challenges. By combining high abundance protein depletion, protein trapping, clean-up, and in-situ tryptic digestion, our workflow is compatible with both qualitative and quantitative MS-based proteomic analysis. The workflow includes collection of endogenous peptides for peptidomic analysis of BALF, if desired, as well as amenability to offline semi-preparative or microscale fractionation of peptide mixtures prior to LC-MS/MS analysis, for increased depth of analysis. We show the effectiveness of this workflow on BALF samples from COPD patients. Overall, our workflow should allow MS-based proteomics to be applied to a wide variety of studies focused on BALF clinical samples. </p> <p>Note: Due to the nature of some of the files, file <em>wendt005_ostr0103_18260_20210831_BALF_FAIMS_MS2_TMT16.msf, wendt005_ostr0103_18976_20230202_quantReport.msf, cmsptc_higgi022_18988_20230203_18976DW_EnF_hcdlT_1R.raw, cmsptc_higgi022_18988_20230203_18976DW_EnF_hcdlT_2R.raw, cmsptc_higgi022_18988_20230203_18976DW_EnF_hcdlT_3R.raw and cmsptc_higgi022_18988_20230203_18976DW_Eclipse_noFAIMS_quantReport.msf</em> were zipped into compressed folders before uploading.</p>
Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy
ClinicalTrials.gov study NCT02912520. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison of gene expression profile of bronchoalveolar lavage fluid (BAL) from RAO- and IAD- affected horses with respect to control animals
GEO Series GSE155084. Equus caballus. 25 samples. Type: Expression profiling by array.
Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer
GEO Series GSE193049. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Single cell gene expression profile of bronchoalveolar lavage fluid (BALF) cells from Apoa1-/- and Apoa1+/+ mice challenged with LPS and house dust mite
GEO Series GSE234287. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of CD11c+ or CD11b+ cells from bronchoalveolar lavage fluid was conducted in a bleomycin-induced pulmonary fibrosis model following GW5074 treatment or in Clec7a KO mice
GEO Series GSE279528. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile at single cell level of Bronchoalveolar Lavage fluid (BALF) cells from mice
GEO Series GSE212402. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Characterisation of resident alveolar macrophages in bronchoalveolar lavage fluid (BALF) in non-fumer healthy, fumer and COPD patients
GEO Series GSE183982. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNAseq analysis (10X Genomics Chromium) of residual bronchoalveolar lavage fluids in healthy, fumer and COPD patients
GEO Series GSE183974. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
A Novel MIP-1 Expressing Macrophage Subtype in Bronchoalveolar Lavage Fluid from Healthy Volunteers
GEO Series GSE197440. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
microRNA expression in bronchoalveolar lavage fluid from mechanically ventilated patients with cardiogenic shock
GEO Series GSE197752. Homo sapiens. 14 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Data from: Correlation between either Cupriavidus or Porphyromonas and primary pulmonary tuberculosis found by analysing the microbiota in patients' bronchoalveolar lavage fluid
Pulmonary tuberculosis (TB) has gained attention in recent decades because of its rising incidence trend; simultaneously, increasing numbers of studies have identified the relationship between microbiota and chronic infectious diseases. In our work, we enrolled 32 patients with primary TB characterised by unilateral TB lesion formation diagnosed by chest radiographic exam. Bronchoalveolar lavage fluid was taken from both lungs. Twenty-four healthy people were chosen as controls. Pyrosequencing was performed on the V3 hypervariable region of 16S rDNA in all bacterial samples and used as a culture-independent method to describe the phylogenetic composition of the microbiota. Through pyrosequencing, 271,764 amplicons were detected in samples and analysed using tools in the Ribosomal Database Project (RDP) and bioinformatics. These analyses revealed significant differences in the microbiota in the lower respiratory tract (LRT) of TB patients compared with healthy controls; in contrast, the microbiota of intra/extra-TB lesions were similar. These results showed that the dominant bacterial genus in the LRT of TB patients was Cupriavidus and not Streptococcus, which resulted in a significant change in the microbiota in TB patients. The abundance of Mycobacteria and Porphyromonas significantly increased inside TB lesions when compared with non-lesion-containing contralateral lungs. From these data, it can be concluded that Cupriavidus plays an important role in TB's secondary infection and that in addition to Mycobacteria, Porphyromonas may also be a co-factor in lesion formation. The mechanisms underlying this connection warrant further research.
PCR for Aspergillus Fumigatus in Blood and Bronchoalveolar Lavage Fluid for Monitoring Cases of Invasive Aspergillosis: What is Its Prognostic Value
ClinicalTrials.gov study NCT07313527. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cytokine Change in Bronchoalveolar Lavage Fluid After Early Budesonide-Surfactant Treatment in Premature Infants
ClinicalTrials.gov study NCT00146497. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study Bronchoalveolar Lavage Fluid Driven Pathogenic Diagnosis of Lower Respiratory Tract Infections
ClinicalTrials.gov study NCT02852070. IPD Sharing: NO. Countries: 1. Publications: 0.
Bio Metrology of Nonfibrous Mineral Particles in Bronchoalveolar Lavage Fluids
ClinicalTrials.gov study NCT03917485. IPD Sharing: NO. Countries: 1. Publications: 0.
Rapid Detection of Pseudomonas Aeruginosa in Bronchoalveolar Lavage Fluid Using Label-free Single-particle Imaging Technology and Assessment of Post-treatment Efficacy in Patients With Pseudomonas Aer
ClinicalTrials.gov study NCT06986512. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exploratory Study of Potential Pulmonary Aspiration Markers From Bronchoalveolar Lavage Fluid
ClinicalTrials.gov study NCT00915941. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia
ClinicalTrials.gov study NCT01865266. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid
GEO Series GSE254166. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
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