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44 results for “CA3”
Mimicking CA3 Temporal Dynamics Controls Limbic Ictogenesis
<p>This dataset includes the microelectrode array recordings from the paper Mimicking CA3 Temporal Dynamics Controls Limbic Ictogenesis.</p>
Data from: Theta oscillations coincide with sustained hyperpolarization in CA3 pyramidal cells, underlying decreased firing
<p>Brain-state fluctuations modulate membrane potential dynamics of neurons, influencing the functional repertoire of the network. Pyramidal cells (PCs) in hippocampal CA3 are necessary for rapid memory encoding, preferentially occurring during exploratory behavior in the high-arousal theta state. However, the relationship between the membrane potential dynamics of CA3 PCs and theta has not been explored. Here, we characterize the changes in the membrane potential of PCs in relation to theta using electrophysiological recordings in awake mice. During theta, most PCs behave in a stereotypical manner, consistently hyperpolarizing time-locked to the duration of theta. Additionally, PCs display lower membrane potential variance and reduced firing rate. In contrast, during large irregular activity, a low-arousal state, PCs show heterogeneous changes in membrane potential. This suggests coordinated hyperpolarization of PCs during theta, possibly caused by increased inhibition. This could lead to higher signal-to-noise ratio in the small population of PCs active during theta as observed in ensemble recordings.</p>
CA3 axonal calcium imaging
<p>Memorizing locations that are harmful or dangerous is a key capability of all organisms, and requires an integration of affective and spatial information. In mammals, the dorsal hippocampus mainly processes spatial information, while the intermediate to ventral hippocampal divisions receive affective information via the amygdala. However, how spatial and aversive information is integrated is currently unknown.</p> <p>To address this question, we recorded the activity of hippocampal long-range CA3 axons at single axon resolution in mice forming an aversive spatial memory. We show that intermediate CA3 to dorsal CA3 (i-dCA3) projections rapidly overrepresent areas preceding the location of an aversive stimulus, due to a spatially selective addition of newly place-coding axons, followed by a spatially nonspecific stabilization. This sequence significantly improves the encoding of location by the i-dCA3 axon population.</p> <p>These results suggest that i-dCA3 axons transmit a precise, denoised and stable signal indicating imminent danger to dorsal hippocampus.</p>
Lateralization of CA1 assemblies in the absence of CA3 input
<p>Raw data (sorted spikes, local field potentials, behavior) for the paper "Lateralization of CA1 assemblies in the absence of CA3 input" Guan et al., <em>Nat Commun</em>, (2021). Each zip file contain data recorded from single mouse. Mice HX384, HX385, HX388, HX443 constitute the 'control' group. Mice HX1582, HX1584, HX386, HX387, HX400 constitute the 'mutants' (CA3-TeTX) group.</p>
Data from: Theta oscillations coincide with sustained hyperpolarization in CA3 pyramidal cells, underlying decreased firing
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CA3 axonal calcium imaging
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Impact of the entorhinal feed-forward connection to the CA3 on hippocampal coding
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OGD triggered Zn2+ rises and Ca2+ deregulation events in CA1 and CA3 hippocampal pyramidal neurons of MT-III and ZnT3 knockout mice.
<p>The posted data provide the control characterization of the oxygen glucose deprivation (OGD) triggered occurrences of cytosolic Zn<sup>2+</sup> rises and terminal Ca<sup>2+</sup> deregulation events in individual CA1 and CA3 pyramidal neurons in acute hippocampal slices of the MT-III knockout mice ( <strong>004649 - 129S7-Mt3<sup>tm1Rpa</sup>/J</strong>, Jackson Laboratory) and ZnT3 knockout mice ( <strong>005064 -</strong> <strong>B6;129-Slc30a3<sup>tm1Rpa</sup>/J</strong>, Jackson Laboratory).</p>
Data from: DG-CA3 circuitry mediates hippocampal representations of latent information
<p>Survival in complex environments necessitates a flexible navigation system that incorporates memory of recent behavior and associations. Yet, how the hippocampal spatial circuit represents latent information independent of sensory inputs and future goals has not been determined. To address this, we imaged the activity of large ensembles in subregion CA1 via wide-field fluorescent microscopy during a novel behavioral paradigm. Our results demonstrated that latent information is represented through reliable firing rate changes during unconstrained navigation. We then hypothesized that the representation of latent information in CA1 is mediated by pattern separation/completion processes instantiated upstream within the dentate gyrus (DG) and CA3 subregions. Indeed, CA3 ensemble recordings revealed an analogous code for latent information. Moreover, selective chemogenetic inactivation of DG-CA3 circuitry completely and reversibly abolished the CA1 representation of latent information. These results reveal a causal and specific role of DG-CA3 circuitry in the maintenance of latent information within the hippocampus.</p> <p> </p>
Formation and Retrieval of Cell Assemblies in a Biologically Realistic Spiking Neural Network Model of Area CA3 in the Mouse Hippocampus
<p>Dataset accompanying the manuscript "Formation and Retrieval of Cell Assemblies in a Biologically Realistic Spiking Neural Network Model of Area CA3 in the Mouse Hippocampus". This dataset is used to re-create all figure panels with underlying data in the manuscript.</p>
Data from: Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3
Much of the research on cannabinoids (CBs) has focused on their effects at the molecular and synaptic level. However, the effects of CBs on the dynamics of neural circuits remains poorly understood. This study aims to disentangle the effects of CBs on the functional dynamics of the hippocampal Schaffer collateral synapse by using data-driven nonparametric modeling. Multi-unit activity was recorded from rats doing an working memory task in control sessions and under the influence of exogenously administered tetrahydrocannabinol (THC), the primary CB found in marijuana. It was found that THC left firing rate unaltered and only slightly reduced theta oscillations. Multivariate autoregressive models, estimated from spontaneous spiking activity, were then used to describe the dynamical transformation from CA3 to CA1. They revealed that THC served to functionally isolate CA1 from CA3 by reducing feedforward excitation and theta information flow. The functional isolation was compensated by increased feedback excitation within CA1, thus leading to unaltered firing rates. Finally, both of these effects were shown to be correlated with memory impairments in the working memory task. By elucidating the circuit mechanisms of CBs, these results help close the gap in knowledge between the cellular and behavioral effects of CBs.
Sample datasets for review of "Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3"
<p>2 sample .tiff stacks and desired output files for use in evaluating the algorithm described in "Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3"</p>
Data from: DG-CA3 circuitry mediates hippocampal representations of latent information
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Data from: Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3
Open the record for dataset details and reuse information.
Efficient generation of human CA3 neurons and modeling hippocampal neuronal connectivity in vitro (single cells)
GEO Series GSE111978. Homo sapiens. 507 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis reveals distinct adaptive molecular mechanism in the hippocampal CA3 from rats susceptible or not-susceptible to hyperthermia-induced seizures
GEO Series GSE229748. Rattus norvegicus. 20 samples. Type: Non-coding RNA profiling by array.
Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons
GEO Series GSE214392. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis reveals distinct adaptive molecular mechanism in the hippocampal CA3 from rats susceptible or not-susceptible to hyperthermia-induced seizures
GEO Series GSE229758. Rattus norvegicus. 16 samples. Type: Non-coding RNA profiling by array.
Hippocampal CA3 Transcriptional Modules Associated with Granule Cell Alterations and Cognitive Impairment in Refractory Mesial Temporal Lobe Epilepsy Patients
GEO Series GSE163296. Homo sapiens. 22 samples. Type: Expression profiling by array.
Efficient generation of human CA3 neurons and modeling hippocampal neuronal connectivity in vitro (bulk)
GEO Series GSE111977. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.