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8 results for “Campylobacter jejuni infection”
Recurrent Campylobacter jejuni infections with in vivo selection of resistance to macrolides and carbapenems – assembly dataset
<p><strong>Dataset</strong></p> <p>This dataset comprises the genome assemblies of the first isolate collected from each clinical case (A1 and B1), together with the respective annotation.</p> <p>File “Cje_metadata.xlsx” contains the genome assembly statistics for each isolate, including the European Nucleotide Archive (ENA) accession numbers, genotyping and antibiotic resistance profiles.</p> <p>The directory “Assemblies/” contains the genome assembly (.fasta and .gbk formats) of each isolate presented in the metadata file.</p> <p> </p> <p><strong>Genome assembly and annotation</strong></p> <p>Reads quality control and improvement, species confirmation (using the 8GB database available at https://ccb.jhu.edu/software/kraken/) and <em>de novo</em> assembly were performed using the INNUca v4.2.2 pipeline (https://github.com/B-UMMI/INNUca). Briefly, after reads’ quality analysis using FastQC v0.11.5 (http://www.bioinformatics.babraham.ac.uk/projects/fastqc/) and cleaning with Trimmomatic v0.38 (http://www.usadellab.org/cms/?page=trimmomatic), genomes were <em>de novo</em> assembled with SPAdes 3.14.0 (http://bioinf.spbau.ru/spades) with a mean depth of coverage above 160x, and subsequently improved using Pilon v1.23. Multi-Locus Sequence Typing (MLST) was performed using mlst v2.18.1 software (https://github.com/tseemann/mlst). Genome annotation was performed with RAST server v2.0 (http://rast.nmpdr.org/).</p> <p>The raw sequence reads of each isolate were deposited at ENA under the study accession numbers PRJEB42628 and PRJNA505131.</p> <p> </p> <p><strong>Funding</strong></p> <p>This work was supported by GenomePT (ref. POCI-01-0145-FEDER-022184) from Fundação para a Ciência e Tecnologia, Portugal.</p>
Data from: Campylobacter jejuni infection associated with relatively poor condition and low survival in a wild bird
Campylobacter jejuni is the most common foodborne pathogen in industrialized countries. Most human infections come from contaminated poultry, but wild birds are also known to harbor C. jejuni. Wild birds are often described as asymptomatic carriers, but this assumption is based on domestic poultry research. We studied the effects of C. jejuni infection on body condition and survival of adult and nestling American crows Corvus brachyrhynchos in Davis, California. Previous work demonstrated that more than half of the crows in this population are infected with C. jejuni and that at least some of the isolates carried by crows are similar to those found in domestic animals and humans. In this study, we compared the body condition of infected and uninfected individuals at the time of capture among adults (n = 44; 52% infected) and nestlings (n = 97; 77% infected). We subsequently monitored these banded individuals for up to 3 yr and used mark–recapture survival analysis to estimate relationships between infection status and later survival. We found that adult crows infected with C. jejuni were in poor condition relative to uninfected adults: average body mass of infected birds was 12% lower, whereas average body size did not differ between the two groups. Likewise, apparent survival probability was lower for infected adults. In contrast, nestling body condition, fledging success, and survival did not differ by infection status. This is the first study to document adverse effects of C. jejuni infection in a free-living, wild bird. If these effects are widespread, C. jejuni exposure may be a cause of conservation concern for some species, especially when human activities increase exposure to infections or introduce novel strains to wild bird populations. Our results add to the growing body of work demonstrating hidden long-term costs of seemingly mild infections in wild populations.
Data from: Campylobacter jejuni infection associated with relatively poor condition and low survival in a wild bird
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MicroRNA expression in chicken cecum following Campylobacter jejuni infection
GEO Series GSE58767. Gallus gallus. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Campylobacter jejuni Cas9 is necessary for efficient infection of Caco-2 cells and cell stress induction
GEO Series GSE89661. Homo sapiens. 33 samples. Type: Expression profiling by array.
Glycosylation-related gene expression in the mucous-secreting gastrointestinal cell line HT29-MTX-E12 in response to infection by Campylobacter jejuni
GEO Series GSE107565. Homo sapiens. 5 samples. Type: Expression profiling by array.
Glycosylation-related gene expression in gastrointestinal cell line HT29 in response to infection by Campylobacter jejuni
GEO Series GSE107563. Homo sapiens. 4 samples. Type: Expression profiling by array.
Genome-Wide Gene Expression Profiling Of Chicken Spleen Responding To Campylobacter jejuni Infection In Broilers
GEO Series GSE18541. Gallus gallus. 24 samples. Type: Expression profiling by array.
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