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160 results for “Cancer cell metabolism”
Suplementary data, results and scripts: "Reconstruction of Cell-specific Models Capturing the Influence of Metabolism on DNA methylation in Cancer"
<p>This repository contains supplementary data, models and scripts associated with "Reconstruction of Cell-specific Models Capturing the Influence of Metabolism on DNA methylation in Cancer".</p><p>Folders content:</p><p>'data_results_matlabscripts': data, result files and scripts (original python scripts and adapted MATLAB scripts)</p><p>'supplementary_figures': supplementary figures</p><p>'supplementary_tables': supplementary tables</p>
Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
<p>Malignant tumors exhibit altered metabolism resulting in a highly acidic extracellular microenvironment. Here we show that cytoplasmic lipid droplet (LD) accumulation, indicative of a lipogenic phenotype is a cellular adaption to extracellular acidity. LD marker PLIN2, is strongly associated with poor overall survival in breast cancer patients. Acid-induced LD accumulation is triggered by activation of the acid-sensing GPCR, OGR1 expressed highly in breast tumors. OGR1 depletion inhibited acid induced lipid accumulation while activation by synthetic agonist triggered LD formation. Inhibition of OGR1 downstream signaling abrogated the lipogenic phenotype which could be rescued with OGR1 ectopic expression. OGR1 depleted cells showed growth inhibition under acidic growth conditions in vitro and tumor formation in vivo. Isotope tracing showed that the source of lipid precursors is primarily autophagy-derived ketogenic amino acids. OGR1 depleted cells were defective in endoplasmic reticulum stress response and autophagy, hence failed to accumulate LDs affecting survival under acidic stress.</p>
Datasets: Carbon sources and pathways for citrate secreted by human prostate cancer cells determined by NMR tracing and metabolic modeling
<p>Zipped NMR datasets:</p> <p>data1 LNCaP medium with [U-<sup>13</sup>C<sub>4</sub>]aspartate</p> <p>data2 LNCaP medium with [1,6-<sup>13</sup>C<sub>2</sub>]glucose</p> <p>data3 LNCaP medium with [2-<sup>13</sup>C]pyruvate</p> <p>data4 VCaP medium with [1,6-<sup>13</sup>C<sub>2</sub>]glucose</p> <p>data5 VCaP medium with [U-<sup>13</sup>C<sub>4</sub>]aspartate -glucose +pyruvate</p> <p>data6 VCaP medium with [5-<sup>13</sup>C]glutamine</p> <p>data7 VCaP medium with [2-<sup>13</sup>C]pyruvate -glucose +aspartate</p> <p>data8 VCaP medium with [5-<sup>13</sup>C]glutamine</p> <p>data9 VCaP medium with [5-<sup>13</sup>C]glutamine</p> <p>data10 VCaP medium with [5-<sup>13</sup>C]glutamine</p> <p>data11 LNCaP and VCaP medium with and without zinc(II)</p> <p>data12 LNCaP and VCaP medium with and without zinc(II)</p> <p>data13 LNCaP and VCaP medium with and without zinc(II)</p> <p>data14 LNCaP medium with [U-<sup>13</sup>C<sub>4</sub>]aspartate -glucose +pyruvate</p> <p>data15 LNCaP medium with [5-<sup>13</sup>C]glutamine</p> <p>data16 LNCaP medium with [2-<sup>13</sup>C]pyruvate</p> <p>data17 LNCaP medium with [5-<sup>13</sup>C]glutamine</p> <p>data18 VCaP medium with [1,6-<sup>13</sup>C<sub>2</sub>]glucose</p> <p>data19 VCaP medium with [1,6-<sup>13</sup>C<sub>2</sub>]glucose</p> <p>data20 VCaP medium with [2-<sup>13</sup>C]pyruvate</p> <p>data21 LNCaP medium with [2-<sup>13</sup>C]pyruvate</p> <p>data22 LNCaP medium with [2-<sup>13</sup>C]pyruvate +citr. Spiking</p> <p>data23 LNCaP medium with [5-<sup>13</sup>C]glutamine</p> <p>data24 LNCaP medium with [5-<sup>13</sup>C]glutamine</p> <p>data25 LNCaP medium with [2-<sup>13</sup>C]pyruvate</p> <p>data26 VCaP medium with [2-<sup>13</sup>C]pyruvate</p> <p>data27 VCaP medium with [2-<sup>13</sup>C]pyruvate -glucose +aspartate</p> <p>data28 VCaP medium with [U-<sup>13</sup>C<sub>4</sub>]aspartate -glucose +pyruvate</p> <p>data29 LNCaP medium with [2-<sup>13</sup>C]pyruvate</p> <p>data30 LNCaP medium with [2-<sup>13</sup>C]pyruvate</p> <p>data31 LNCaP medium with [2-<sup>13</sup>C]pyruvate</p> <p>data32 VCaP medium with [2-<sup>13</sup>C]pyruvate -glucose +aspartate</p> <p>data33 VCaP medium with [U-<sup>13</sup>C<sub>4</sub>]aspartate -glucose +pyruvate</p> <p>data34 VCaP medium with [U-<sup>13</sup>C<sub>4</sub>]aspartate -glucose +pyruvate</p> <p>data35 LNCaP medium with [U-<sup>13</sup>C<sub>4</sub>]aspartate</p> <p>data36 VCaP medium with [U-<sup>13</sup>C<sub>4</sub>]aspartate -glucose +pyruvate</p> <p>data37 LNCaP medium with [5-<sup>13</sup>C]glutamine + citr. spiking</p>
Source data sets_Figure 1, 2, 6_Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity
<p>Flow cytometry data files associated with Copland <em>et al., </em><strong><em><span>Salmonella </span></em></strong><strong><span>cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity.</span></strong></p> <p><span>Data associated to Figures 1, 2 and 6. <br></span></p>
Profiling single cancer cell metabolism via high-content SRS imaging with chemical sparsity
<p>Raw data for Profiling single cancer cell metabolism via high-content SRS imaging with chemical sparsity </p>
Assessing the Efficacy and Safety of Selective Metabolically Adaptive Radiation Dose Escalation in Locally Advanced Non-Small Cell Lung Cancer Receiving Definitive Chemoradiotherapy
ClinicalTrials.gov study NCT02788461. IPD Sharing: NO. Countries: 1. Publications: 1.
Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling
ClinicalTrials.gov study NCT02083692. IPD Sharing: Not stated. Countries: 1. Publications: 3.
18F-FDG Metabolism Imaging Monitoring Non-small Cell Lung Cancer Curative Effect of Chemotherapy Multicenter Clinical Study
ClinicalTrials.gov study NCT02938546. IPD Sharing: UNDECIDED. Countries: 0. Publications: 13.
Metabolic Biomarkers Predicting Response to Neoadjuvant Immunotherapy in Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT07084610. IPD Sharing: YES. Countries: 1. Publications: 0.
Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells [HPAF-2]
GEO Series GSE292890. Homo sapiens. 16 samples. Type: Expression profiling by array.
Gene expression microarray and CGH array of metabolically adaptable cells derived from SUM149 triple-negative Inflammatory Breast Cancer cell line
GEO Series GSE60017. Homo sapiens. 5 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array.
Porphyrin overdrive rewires cancer cell metabolism
GEO Series GSE263829. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
The mevalonate pathway is required for pyrimidine synthesis and survival of p53-deficient colon cancer cells in metabolically compromised environments
GEO Series GSE124189. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
GEO Series GSE80586. Homo sapiens. 4 samples. Type: Non-coding RNA profiling by array.
Apolipoprotein A-I Anti-tumor Activity Targets Cancer Cell Metabolism
GEO Series GSE137532. Mus musculus. 32 samples. Type: Expression profiling by array.
TANK binding kinase 1 induces transcription factor BACH1 to regulate iron metabolism in pancreatic cancer cells
GEO Series GSE201307. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Cancer-associated fibroblasts metabolic targeting overcomes T-cell exclusion and chemoresistance
GEO Series GSE237638. Mus musculus; Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
CDK4 Inactivation Hinders Cell Death and Metabolism Remodeling Mitochondria-ER contacts in Triple-Negative Breast cancer cells
GEO Series GSE278524. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non–small cell lung cancer cells in HIF-dependent and HIF-independent manner
GEO Series GSE239389. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Using constraint-based metabolic modeling to elucidate drug-induced metabolic changes in a cancer cell line
GEO Series GSE285616. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.