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12 results for “Carbapenem-resistant Klebsiella pneumoniae”
Polyphasic characterization of carbapenem-resistant Klebsiella pneumoniae clinical isolates suggests vertical transmission of the blaKPC-3 gene
<p>Optical DNA mapping (ODM) data related to the study, presented in figures 2-6 in the paper.</p>
IMPACT OF TEBIPENEM-PIVOXIL ON THE INTESTINAL MICROBIOTA AND ON ESTABLISHMENT OF COLONIZATION WITH CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE IN MICE
<p><span>Antimicrobial therapy has the</span><span> potential to cause unintended adverse effects by promoting antibiotic-resistant bacteria. Therefore, as new antibiotics are developed there is a need to understand their potential to disrupt the indigenous microbiota of the colon and promote colonization by pathogens. Tebipenem pivoxil (Teb-piv), the first oral carbapenem, has potent <em>in vitro</em> activity against <em>Enterobacterales</em> pathogens, but requires combination with an appropriate β-lactamase inhibitor to achieve activity against <em>Klebsiella pneumoniae</em> carbapenemase and metallo-β-lactamase (MBL)-producing carbapenem-resistant <em>Enterobacterales</em></span></p>
Data from: Clinical outcomes and safety of polymyxin B versus tigecycline combination therapy for pneumonia of carbapenem-resistant Klebsiella pneumoniae: A retrospective cohort study
<p><strong>Purpose:</strong> Infection by carbapenem-resistant <em>Klebsiella pneumoniae</em> (CRKP) has high mortality. There is no clear optimal therapeutic choice for pneumonia caused by CRKP. The aim of this study was to compare the clinical outcomes and safety of the standard doses of polymyxin B-based regimens vs tigecycline-based regimens and to identify risk factors for mortality.</p> <p><strong>Methods:</strong><strong> </strong>This retrospective cohort study included patients with pneumonia caused by CRKP for three years. The primary outcomes were 7-day bacterial eradication rate and 14- and 28-day all-cause mortality. The secondary outcome was incidence of acute kidney injury.</p> <p><strong>Results:</strong><strong> </strong>Seventy-three patients were included in this study, 29 in the<strong> </strong>polymyxin B-based combination therapy group and 44 in tigecycline-based combination therapy group. There were no significant differences between the two groups in terms of the 7-day bacterial eradication rate (31.0% vs 20.5%, <em>P</em>=0.409), the 14-day all-cause mortality (37.9% vs 22.7%, <em>P</em>=0.160), and the incidence of acute kidney injury (14.3% vs 6.8%, <em>P</em>=0.526). The 28-day all-cause mortality in the polymyxin B-based therapy group was higher than in the tigecycline-based group (75.9% vs 45.5%, <em>P</em>=0.010). Binary logistic regression analysis revealed that male and previous use of carbapenems were independent factors associated with 28-day all-cause mortality for patients treated with polymyxin B (<em>P</em><0.05).</p> <p><strong>Conclusions:</strong><strong> </strong>Polymyxin B-based combination therapy at the standard dose should be used with caution for patients with CRKP-induced pneumonia, especially for men who used carbapenems prior to CRKP detection.</p>
Selective Digestive Decontamination in Carriers of Carbapenem-resistant Klebsiella Pneumoniae
ClinicalTrials.gov study NCT00753558. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Data from: Clinical outcomes and safety of polymyxin B versus tigecycline combination therapy for pneumonia of carbapenem-resistant Klebsiella pneumoniae: A retrospective cohort study
Open the record for dataset details and reuse information.
Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin
ClinicalTrials.gov study NCT02604849. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Rapid design of bacteriophage cocktails to suppress the burden and virulence of gut-resident carbapenem-resistant Klebsiella pneumoniae
GEO Series GSE272297. Klebsiella pneumoniae. 4 samples. Type: Expression profiling by high throughput sequencing.
Intestinal carbapenem-resistant Klebsiella pneumoniae undergoes complex transcriptional reprogramming following immune activation
GEO Series GSE249468. Klebsiella pneumoniae. 23 samples. Type: Expression profiling by high throughput sequencing.
Network integrative genomic and transcriptomic analysis of carbapenem-resistant Klebsiella pneumoniae strains identifies genes for resistance and virulence
GEO Series GSE115539. Klebsiella pneumoniae. 4 samples. Type: Expression profiling by high throughput sequencing.
Risk Factors for Pyogenic Liver Abscess With Carbapenem-resistant Klebsiella Pneumoniae: A Matched Case-control Study
ClinicalTrials.gov study NCT05521139. IPD Sharing: NO. Countries: 1. Publications: 0.
Epidemiological Characteristics and Treatment Protocol for Carbapenem-Resistant Klebsiella Pneumoniae in China
ClinicalTrials.gov study NCT03245632. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Clinical Outcomes of Hypervirulent Carbapenem-resistant Klebsiella Pneumoniae Infection
ClinicalTrials.gov study NCT06190548. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.