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887 results for “Cataract”
Dataset for 'Intraocular scatter compensation with spatial light amplitude modulation for improved vision in simulated cataractous eyes'
<p>Dataset for the manuscript entitled: Intraocular scatter compensation with spatial light amplitude modulation for improved vision in simulated cataractous eyes</p> <p>includes:</p> <p>1) PSF from numerical simulations</p> <p>2) CSF measured in subjects</p> <p>3) Michelson contrast from numerical simulations</p>
SICS-105: Phase recognition in Manual Small-Incision Cataract Surgery
<p><span>This prospective cross-sectional study introduces the first Manual Small-Incision Cataract Surgery (SICS) video dataset, which is prevalent but understudied in low- and middle-income countries (LMICs), evaluates effectiveness of phase recognition through deep learning (DL) using the MS-TCN++ architecture and compares its results with the well-studied phacoemulsification procedure using the Cataract-101 public dataset. Our novel SICS-105 dataset involved 105 patients recruited at Sankara Eye Hospital in India. Performance is evaluated with frame-wise accuracy, edit distance, F1-score, Precision-Recall AUC, sensitivity, and specificity. The MS-TCN++ architecture performs better on the Cataract-101 dataset across reported metrics, with an accuracy of 89.97% [CI 86.69-93.46%] compared to 84.94% [CI 79.45-92.03%] on the SICS-105 dataset (ROC AUC 99.10% [98.34-99.51%] vs. 98.22% [97.17-99.39%]). Reducing the 20 phases to 13 phase in SICS improved performance without completely bridging the gap. The per-video accuracy distribution and confidence-intervals overlap between the samples. PR-AUC curves for each phase in the SICS dataset range from 46.20 to 94.18%. In conclusion, we replicated phase recognition results from phacoemulsification in a new open-access SICS dataset using DL with slightly lower prediction performance. This research marks a crucial step towards improving postoperative analysis and training for SICS.</span></p>
Linked collectors and determiners for: The structure of the cataract causing P 23 T mutant of human gamma-D crystallin.
Natural history specimen data linked to collectors and determiners held within, "The structure of the cataract causing P 23 T mutant of human gamma-D crystallin". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="https://bionomia.net/dataset/4caaf0c8-bd51-4d80-86ba-5544792d65ce">https://bionomia.net/dataset/4caaf0c8-bd51-4d80-86ba-5544792d65ce</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/4caaf0c8-bd51-4d80-86ba-5544792d65ce">https://gbif.org/dataset/4caaf0c8-bd51-4d80-86ba-5544792d65ce</a>. Formatted as a Frictionless Data package.
Gender and age-related differences of ccular biometric parameters in patients undergoing cataract surgery in Bosnia and Herzegovina
<p><strong>Purpose</strong>: To determine the distribution and mutual relationship of ocular biometric parameters, as well as to evaluate gender- and age-related differences in patients undergoing cataract surgery in Bosnia and Herzegovina.</p> <p><strong>Materials and methods</strong>: It was a retrospective cross-sectional study of consecutive patients who underwent cataract surgery between January 2017 and December 2021 in a tertiary care clinic. All biometric measurements were performed using the optical biometer OA-2000 (Tomey, Nagoya, Japan).</p> <p><strong>Results</strong>: The study evaluated 1278 eyes from 1278 consecutive cataract patients. The average age of all included patients was 69.4 ± 9.98 (range 40–96). A total of 672 eyes (52.58%) were from females. The mean axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and mean keratometry were 23.46±1.18mm, 3.17±0.40mm, 4.54±0.48mm, 43.42±1.55D respectively. Corneal astigmatism of ≥1D, >2D and >3D was found in 33.4%, 7.8% and 2.5% patients, respectively. Females were found to have shorter AL (p<0.0001), shallower ACD (p<0.0001) and steeper corneas (p<0.0001). In both genders, AL, ACD and with-the-rule astigmatism showed a decreasing trend (p=0.0001), while keratometry, the average cylinder, and against-the-rule astigmatism showed an increasing trend (p=0.0001) with increasing age. Furthermore, in both genders, there was an increasing trend in ACD (p=0.0001), and a decreasing trend in keratometry (p=0.0001) and LT (p=0.0001) with increasing AL.</p> <p><strong>Conclusions</strong>: This study provides useful reference data on ocular biometry for cataract surgeons in Bosnia and Herzegovina. Female patients tend to have steeper corneas, shorter AL and shallower AC than males, and these differences are independent of age or AL.</p>
Clinical and genetic findings in an Italian cohort of individuals with congenital cataract
<p>List of variants and associated clinical phenotypes identified in a cohort of individuals affected by congenital cataract (syndromic and non-syndromic forms) that have been submitted to the public ClinVar repository (https://www.ncbi.nlm.nih.gov/clinvar/) with their corresponding accession numbers.</p>
Loss of alpha Ba-crystallin, but not alpha A-crystallin, increases age-related cataract in the zebrafish lens
<p>The vertebrate eye lens is an unusual organ in that most of its cells lack nuclei and the ability to replace aging protein. The small heat shock protein α-crystallins evolved to become key components of this lens, possibly because of their ability to prevent aggregation of aging protein that would otherwise lead to lens opacity. Most vertebrates express two α-crystallins, αA- and αB-crystallin, and mutations in each are linked to human cataract. In a mouse knockout model, only the loss of αA-crystallin led to early-stage lens cataract. We have used the zebrafish as a model system to investigate the role of α-crystallins during lens development. Interestingly, while zebrafish express one lens-specific αA-crystallin gene (<em>cryaa</em>), they express two αB-crystallin genes, with one evolving lens specificity (<em>cryaba</em>) and the other retaining the broad expression of its mammalian ortholog (<em>cryabb</em>). In this study, we used individual mutant zebrafish lines for all three α-crystallin genes to determine the impact of their loss on age-related cataract. Surprisingly, unlike mouse knockout models, we found that the loss of the αBa-crystallin gene <em>cryaba</em> led to an increase in lens opacity compared to <em>cryaa</em> null fish at 24 months of age. Loss of αA-crystallin did not increase the prevalence of cataract. We also used single-cell RNA-Seq and RT-qPCR data to show a shift in the lens expression of zebrafish α-crystallins between 5 and 10 days post fertilization (dpf), with 5 and 6 dpf lenses expressing <em>cryaa</em> almost exclusively, and expression of <em>cryaba</em> and <em>cryabb</em> becoming more prominent after 10 dpf. These data show that <em>cryaa</em> is the primary α-crystallin during early lens development, while the protective role for <em>cryaba</em> becomes more important during lens aging. This study is the first to quantify cataract prevalence in wild-type aging zebrafish, showing that lens opacities develop in approximately 25% of fish by 18 months of age. None of the three α-crystallin mutants showed a compensatory increase in the expression of the remaining two crystallins, or in the abundant βB1-crystallin. Overall, these findings indicate an ontogenetic shift in the functional importance of individual α-crystallins during zebrafish lens development. Our finding that the lens-specific zebrafish αBa-crystallin plays the leading role in preventing age-related cataract adds a new twist to our understanding of vertebrate lens evolution.</p>
Geo-Archaeology and Historical Nile Records to Understand Predynastic Settlement Patterns (First Nile Cataract, Egypt)
<p>This upload contains the relevant shapefiles and images related to our article "Combining Geo-Archaeology and Historical Nile Records to Understand Predynastic Settlement Patterns in the Region of the Nile's First Cataract, Egypt" in <em>Old World</em>. </p> <p>The BORDERSCAPE Project Old World Repository: Description of Contents</p> <p>Data are stored in a folder named<br>"OLD_WORLD_borderscape_raw_data"</p> <p>Singular files are:<br>"README.txt": A document describing the contents of this repository.<br>"93m_floodplain.tif": A GEOtif showing flooded areas at 93m ASL.<br>"93.3m_floodplain.tif": A GEOtif showing flooded areas at 93.3m ASL.<br>"94.5m_floodplain.tif": A GEOtif showing flooded areas at 94.5m ASL.<br>"flooding_622to1911.tif": A GEOtif showing flooded areas according to flooding measurments recorded from AD 622 to 1911.</p> <p>ZIP archives are:<br>"OLD_WORLD_borderscape_archaeological_sites.zip": A zip folder of a shapefile showing the archaeological sites.<br>"drillings.zip": A zip folder of a shapefile showing drillings in Nag el-Qarmila.<br>"geology_NQ.zip": A zip folder of a shapefile showing geology polygons in Nag el-Qarmila.<br>"WK14_cemetery.zip": A zip folder of a shapefile showing the area of cemetery WK14 in Nag el-Qarmila.<br>"WK15_settlement.zip": A zip folder of three shapefile showing the settlement WK15, area A and area B in Nag el-Qarmila.<br>"WK22_storage_area.zip": A zip folder of a shapefile showing storage area WK22 in Nag el-Qarmila.</p>
Video Dataset of 101 Cataract Surgeries
<p>This dataset contains 101 videos of cataract surgeries annotated with two kinds of information:</p> <ul> <li>(Anonymous) ID and experience level of operating surgeon</li> <li>Starting points of quasi-standardized operation phases in videos</li> </ul> <p>The cataract surgeries have been performed by four different surgeons of two levels of experience (low, high).</p> <p>The dataset has been collected and annotated by ophthalmic surgeons of<br> Klinikum Klagenfurt, and has been prepared and provided by the Institute of<br> Information Technology (ITEC) of Alpen-Adria-Universitaet (AAU) Klagenfurt, Austria.</p>
A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms
ClinicalTrials.gov study NCT02028754. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparing Single Versus Multiple Anti-VEGF Injections in Diabetic Patients Undergoing Cataract Surgery
ClinicalTrials.gov study NCT07301775. IPD Sharing: YES. Countries: 1. Publications: 14.
AI-Enhanced Consent for Cataract Surgery
ClinicalTrials.gov study NCT06528509. IPD Sharing: NO. Countries: 1. Publications: 10.
A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
ClinicalTrials.gov study NCT02132312. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Tetracaine 0.5% and Lidocaine 2% Jelly for Topical Phacoemulsification Cataract Surgery
ClinicalTrials.gov study NCT00827073. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery
ClinicalTrials.gov study NCT01847638. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of APP13007 to Treat Inflammation and Pain After Cataract Surgery
ClinicalTrials.gov study NCT04089735. IPD Sharing: NO. Countries: 1. Publications: 0.
Cataract Monitored Anesthesia Care (MAC) Feasibility Pilot Study
ClinicalTrials.gov study NCT06506669. IPD Sharing: NO. Countries: 1. Publications: 40.
Clinical Study to Evaluate the Safety and Performance of the enVista® One-Piece Hydrophobic Acrylic Trifocal Intraocular Lens in Subjects Undergoing Cataract Extraction
ClinicalTrials.gov study NCT04224155. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Safety & Effectiveness Study of the Hydrus Microstent for Lowering IOP in Glaucoma Patients Undergoing Cataract Surgery (HORIZON)
ClinicalTrials.gov study NCT01539239. IPD Sharing: Not stated. Countries: 9. Publications: 2.
Loteprednol Etabonate Versus Vehicle for the Treatment of Inflammation and Pain Following Cataract Surgery
ClinicalTrials.gov study NCT01010633. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-1)
ClinicalTrials.gov study NCT04246801. IPD Sharing: NO. Countries: 1. Publications: 11.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.