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Dataset results
131 results for “Central pain”
Study of Mirogabalin for Central Neuropathic Pain
ClinicalTrials.gov study NCT03901352. IPD Sharing: YES. Countries: 3. Publications: 3.
Pain Experiences of Patients with Musculoskeletal Pain and Central Sensitization: A comparative Group Delphi Study
<p>Central sensitization (CS) is regarded as an important contributing factor for chronification of musculoskeletal pain (MSP). It is crucial to identify CS, as targeted multimodal treatment may be indicated. The primary objective of this study was therefore to explore pain experience of individuals with MSP+CS in order to gain a better understanding of symptoms in relation to CS from a patient perspective. The secondary objective was to investigate whether pain experiences of patients with MSP+CS differ from those of individuals with neuropathic pain (NP).</p>
Traumatic events, post-traumatic stress disorder, and proxy measures for central sensitization in chronic pain patients of a German university outpatient pain clinic
<p>This dataset was acquired at Hannover Medical School, Hannover, Germany. The study complied with the Declaration of Helsinki, and was approved by the local ethics committee. All subjects gave written informed consent, and consent to use their data anonymously for research purposes. The study was registered at ClinicalTrials.gov (NCT05190367).</p> <p>Between February 2019 and July 2020, 914 patients who visited our outpatient pain department gave written consent to use their routinely collected data anonymously for research purposes. Participants were divided into four groups depending on their trauma severity: (1) no trauma; (2) accidental trauma (e.g. illness, accident, natural disaster); (3) interpersonal trauma (e.g. assault, rape, war); (4) PTSD (diagnosed according to ICD-10). Patients fulfilling two or more categories were assigned to the highest group.</p> <p>Data were collected using the SymptomMapper application [1]. Participants provided information about their traumas, current pain intensity (visual analogue scale, VAS (0-100) [2]), mean and maximal pain in the last 4 weeks (VAS (0-100)), sleep impairment (VAS (0-100)), acceptable pain (VAS (0-100)), pain disability index (PDI [3]), pain area (digital drawings), pain widespreadness (widespread pain index, WPI [4], derived from drawings), stress (patient health questionnaire, German version, PHQ-D [5]), anxiety (PHQ-D), depression (PHQ-D), and somatization symptoms (PHQ-D).</p> <p>This dataset contains the raw data as well as necessary scripts for reproducing the results of this study.</p> <p> </p> <p>References<br> ##########</p> <p>[1] Neubert TA, Dusch M, Karst M, Beissner F. Designing a Tablet-Based Software App for Mapping Bodily Symptoms: Usability Evaluation and Reproducibility Analysis. JMIR Mhealth Uhealth 2018;6(5):e127.<br> [2] Dworkin RH, Turk DC, Farrar JT et al. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain 2005;113(1):9-19.<br> [3] Pollard CA. Preliminary Validity Study of the Pain Disability Index. Percept Mot Skills 1984;59(3): 974.<br> [4] Wolfe F, Clauw DJ, Fitzcharles MA et al. The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity. Arthritis Care Res 2010;62(5):600-10.<br> [5] Löwe B, Spitzer RL, Zipfel S, Herzog W. Gesundheitsfragebogen für Patienten (PHQ-D). Manual und Testunterlagen (second edition). Pfizer 2002.</p>
Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury
ClinicalTrials.gov study NCT03302793. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Sativex in the Treatment of Central Neuropathic Pain Due to Multiple Sclerosis
ClinicalTrials.gov study NCT01604265. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Central Sensitization in Painful and Painless Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT07316322. IPD Sharing: NO. Countries: 1. Publications: 10.
Sativex Versus Placebo When Added to Existing Treatment for Central Neuropathic Pain in MS
ClinicalTrials.gov study NCT00391079. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain
ClinicalTrials.gov study NCT01202227. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Insular and anterior cingulate cortex deep stimulation for central neuropathic pain: disassembling the percept of pain
Objective: To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study. Methods: Participants were randomly allocated into the active PSI-rTMS, ACC-rTMS, sham-PSI-rTMS, or sham-ACC-rTMS arms. Stimulations were performed for 12 weeks, and a comprehensive clinical and pain assessment, psychophysics, and cortical excitability measurements were performed at baseline and during treatment. The main outcome of the study was pain intensity (numeric rating scale [NRS]) after the last stimulation session. Results: Ninety-eight patients (age 55.02 ± 12.13 years) completed the study. NRS score was not significantly different between groups at the end of the study. Active rTMS treatments had no significant effects on pain interference with daily activities, pain dimensions, neuropathic pain symptoms, mood, medication use, cortical excitability measurements, or quality of life. Heat pain threshold was significantly increased after treatment in the PSI-dTMS group from baseline (1.58, 95% confidence interval [CI] 0.09–3.06]) compared to sham-dTMS (−1.02, 95% CI −2.10 to 0.04, p = 0.014), and ACC-dTMS caused a significant decrease in anxiety scores (−2.96, 95% CI −4.1 to −1.7]) compared to sham-dTMS (−0.78, 95% CI −1.9 to 0.3; p = 0.018). Conclusions: ACC- and PSI-dTMS were not different from sham-dTMS for pain relief in CNP despite a significant antinociceptive effect after insular stimulation and anxiolytic effects of ACC-dTMS. These results showed that the different dimensions of pain can be modulated in humans noninvasively by directly stimulating deeper SNC cortical structures without necessarily affecting clinical pain per se.
Cognitive Behavioral Factors and Central Sensitization in Chronic Shoulder Pain
ClinicalTrials.gov study NCT03838471. IPD Sharing: NO. Countries: 1. Publications: 6.
Psychosocial Factors, Lifestyle and Central Pain Processing as Potential Predictors of Outcome for Rotator Cuff Repair
ClinicalTrials.gov study NCT04946149. IPD Sharing: Not stated. Countries: 1. Publications: 42.
Investigation of the Relationship Between Central Sensitization and Neuropathic Pain in Lumbar Disc Herniation
ClinicalTrials.gov study NCT06269068. IPD Sharing: NO. Countries: 1. Publications: 7.
Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism?
ClinicalTrials.gov study NCT02806440. IPD Sharing: YES. Countries: 1. Publications: 7.
Investigation of the Effect of Central Sensitization Symptom Severity on Steroid Injection Results in Shoulder Pain
ClinicalTrials.gov study NCT06404125. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Central Aspects of Pain in Rheumatoid Arthritis
ClinicalTrials.gov study NCT04515589. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Pain Inhibition in Patients With Rheumatoid Arthritis and Central Sensitivity Syndromes
ClinicalTrials.gov study NCT01154647. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Central Mechanism of Manual Therapy for Low Back Pain
ClinicalTrials.gov study NCT03078114. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls
ClinicalTrials.gov study NCT03703934. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Brain Circuitry Changes in Central Poststroke Pain: a Clinical and Neuroimaging Study
ClinicalTrials.gov study NCT05335668. IPD Sharing: NO. Countries: 1. Publications: 4.
Neurofeedback for Treatment of Central Neuropathic Pain (CNP) in Sub-acute Spinal Cord Injury (SCI)
ClinicalTrials.gov study NCT02178917. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.