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Dataset results
13 results for “Childhood Maltreatment”
Corticolimbic Response to Threat and Recollected Ages of Exposure to Childhood Maltreatment
<p>Data files indicating regional BOLD fMRI response of young adults to negative (angry or fearful) faces versus neutral faces in Hariri amygdala activation face matching task.</p> <p>MACE_scores_BOLD_fMRI_amyg_hipp.csv - Contains overall BOLD fMRI response to negative minus neutral faces in bilateral amygdala, hippocampus, fusiform gyrus, inferior frontal gyrus pars triangularis, ventromedial prefrontal cortex, dorsomedial prefrontal cortex and anterior cingulate cortex as well as Maltreatment and Abuse Chronology of Exposure scores for severity of exposure to 10 types of childhood maltreatment across each age of childhood and parameters for age, sex, parental education and childhood financial sufficiency.</p> <p>Early_vs_late_maltreatment_BOLD_fMRI_amyg_hipp_pfc_fusiform_for_mixed_model.xlsx - Data in long format indicating for each participant baseline adjusted BOLD fMRI response to negative minus neutral faces at each TR interval for amygdala, hippocampus, fusiform gyrus, inferior frontal gyrus pars triangularis, ventromedial prefrontal cortex, dorsomedial prefrontal cortex and anterior cingulate cortex with participants classified as having experienced no maltreatment, only early childhood maltreatment on only late childhood maltreatment based on type / time predictors for each region.</p> <p>Early_vs_late_maltreatment_regional_fMRI_response_negative_vs_neutral_faces.xlsx - Individual participant baseline adjusted data for response to negative faces and neutral faces at each TR interval for amygdala, hippocampus, fusiform gyrus, inferior frontal gyrus pars triangularis, ventromedial prefrontal cortex, dorsomedial prefrontal cortex and anterior cingulate cortex with each participant classified as having experienced no maltreatment, only early childhood maltreatment or only late childhood maltreatment based on region specific definitions.</p> <p>Early_vs_late_maltreatment_time_course_BOLD_fMRI_regional_response.xlsx - Group means and sem for baseline adjusted BOLD fMRI response to negative minus neutral faces at each TR interval for amygdala, hippocampus, fusiform gyrus, inferior frontal gyrus pars triangularis, ventromedial prefrontal cortex, dorsomedial prefrontal cortex and anterior cingulate cortex based on region specific groupings classifications as having experienced no maltreatment, only early childhood maltreatment on only late childhood maltreatment.</p> <p>Early_vs_late_maltreatment_time_course_regional_response_negative_vs_neutral_faces.xlsx - Group means and sem for baseline adjusted BOLD fMRI response to negative faces and neutral faces at each TR interval for amygdala, hippocampus, fusiform gyrus, inferior frontal gyrus pars triangularis, ventromedial prefrontal cortex, dorsomedial prefrontal cortex and anterior cingulate cortex based on region specific groupings classifications as having experienced no maltreatment, only early childhood maltreatment on only late childhood maltreatment.</p> <p> </p>
Watching with Argus Eyes: Characterization of emotional and physiological responding in adults exposed to childhood maltreatment and/or recent adversity
<p><em>Background:</em><br> Exposure to adverse experiences is a well-established major risk factor for affective psychopathology. The vulnerability of deleterious sequelae is assumed in maladaptive processes of the defensive system, particularly in emotional processing. More specifically, childhood maltreatment has been suggested to be associated with the recruitment of specific and distinct defensive response profiles. To date it remains unclear whether these are specific or generalisable to recent adversity in adulthood.</p> <p><br> <em>Method:</em><br> This preregistered study aimed to investigate the impact of exposure to childhood and recent adversity on emotional processing in 685 healthy adults with the “Affective Startle Modulation” Paradigm (ASM).</p> <p><br> <em>Results:</em><br> First, we replicated higher trait anxiety and depression levels in individuals exposed to both types of adversity. Second, we observed blunted general skin conductance reactivity in individuals exposed to recent adversity. Third, individuals <em>exposed to childhood maltreatment</em> showed reduced, while individuals <em>exposed to recent adversity</em> showed increased discrimination between pictures of negative and neutral valence, compared to non-exposed individuals in SCR. No association between exposure to adversity and fear potentiated startle was observed. Furthermore, explorative analyses revealed moderate dimensional and categorical agreement between two childhood maltreatment questionnaires and provide insight into potential adversity-type specific effects.</p> <p><br> <em>Conclusion:</em><br> Our results support experience-dependent plasticity in sympathetic nervous system reactivity and suggest distinct response profiles in affective modulation in individuals exposed to early versus recent adversity. We emphasise the need to further explore distinct adversity profiles to further our understanding on specific psychophysiological profiles and their potential implication for prevention and intervention.</p>
Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
ClinicalTrials.gov study NCT02447744. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Online Emotional Response to Completing a Childhood Maltreatment Self-report Scale
ClinicalTrials.gov study NCT06152549. IPD Sharing: Not stated. Countries: 1. Publications: 21.
Reduce Childhood Maltreatment and Promote Development
ClinicalTrials.gov study NCT03031236. IPD Sharing: NO. Countries: 1. Publications: 27.
Childhood Maltreatment, Traumatic Experiences and Stress-associated Parameters in Schizophrenia Spectrum Disorders
ClinicalTrials.gov study NCT03730831. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
The Unique and Combined Effects of Prenatal and Early Childhood Programming on Child Maltreatment: Examining Mechanisms of Change
ClinicalTrials.gov study NCT06732310. IPD Sharing: NO. Countries: 1. Publications: 0.
Prevention of Childhood Maltreatment in Families With Young Children
ClinicalTrials.gov study NCT04341376. IPD Sharing: YES. Countries: 1. Publications: 0.
Reducing Self-Stigma Among Individuals with History of Childhood Maltreatment
ClinicalTrials.gov study NCT05818228. IPD Sharing: NO. Countries: 1. Publications: 0.
MicroRNA Correlates of Childhood Maltreatment and Suicidality
ClinicalTrials.gov study NCT04923685. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reducing Self-Stigma Among Individuals with History of Childhood Maltreatment: a Cross-Cultural Lens
ClinicalTrials.gov study NCT06159075. IPD Sharing: NO. Countries: 1. Publications: 0.
Childhood maltreatment history for guiding personalized antidepressant choice in major depressive disorder: Preliminary results from a systematic review
<p>Childhood maltreatment history for guiding personalized antidepressant<br> choice in major depressive disorder: Preliminary results from a<br> systematic review</p> <p>Childhood maltreatment (CM) is a predictor of poor outcome across treatments for major depressive disorder<br> (MDD), while its potential role as a predictor of differential responses to specific antidepressants has received<br> little attention. The present systematic review examined pharmacological studies (published up to June 30th,<br> 2020) that included head-to-head comparisons of antidepressant treatments among adult MDD patients with a<br> reported history of CM or no history to evaluate if CM may help clinicians choose antidepressants with greatest<br> likelihood of successful outcome. Only three studies were included, providing limited and provisional results.<br> These preliminary findings suggest that sustained-release bupropion (alone or in combination) or aripiprazoleaugmentation<br> as next-step intervention did not demonstrate differential outcome among MDD patients with or<br> without a history of childhood adversity. Further, sertraline and the group of antidepressants with low affinity for<br> the serotonin transporter may be less suitable for MDD patients with childhood abuse history than escitalopram,<br> venlafaxine-XR, or antidepressants with high affinity for the serotonin transporter. The critical question of the<br> most potentially efficacious treatment regimens for adult MDD with CM history requires further large-sample<br> studies involving a greater number of medications, specifically designed to analyse the moderating effects of<br> different types of CM, and possibly including objective biomarkers.</p>
Does childhood maltreatment make us more morally disengaged? The indirect effect of expressive suppression
<p>Data set for </p> <p><strong>Does childhood maltreatment make us more morally disengaged? The indirect effect of expressive suppression</strong></p> Enable Ginger<em>Cannot connect to Ginger</em> Check your internet connection<br> or reload the browserDisable in this text fieldRephraseRephrase current sentence<span class="ginger-floatingG-bar-tool-mistakes-count">2</span>Log in to edit with Ginger×
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Allen Brain Atlas
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