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6 results for “Chromosomal inversion polymorphism”
An allozyme polymorphism is associated with a large chromosomal inversion in the marine snail Littorina fabalis
<p>This Zenodo archive contains the dataset analysed in the paper "An allozyme polymorphism is associated with a large chromosomal inversion in the marine snail Littorina fabalis" published in Evolutionary Application in 2022:</p> <ul> <li><a href="https://zenodo.org/api/files/cd560cff-56d4-4f72-95be-e70939f2b85f/FAB_LG3_maf1_SNP_Hexcess_depth10.vcf">FAB_LG3_maf1_SNP_Hexcess_depth10.vcf </a>: vcf for LG3 unpruned for LD containing 295 individuals genotyped at 58,246 filtered SNPs</li> <li><a href="https://zenodo.org/api/files/cd560cff-56d4-4f72-95be-e70939f2b85f/FAB_LG3_maf1_SNP_Hexcess_depth10_thin.vcf">FAB_LG3_maf1_SNP_Hexcess_depth10_thin.vcf </a>: vcf for LG3 pruned for LD containing 295 individuals genotyped at 9,905 filtered SNPs</li> <li><a href="https://zenodo.org/api/files/cd560cff-56d4-4f72-95be-e70939f2b85f/FAB_AK_maf1_SNP_Hexcess_depth10.vcf">FAB_AK_maf1_SNP_Hexcess_depth10.vcf</a> : vcf for contig265 containing the arginine kinase gene: 295 individuals genotyped at 70 filtered SNPs</li> </ul> <p>The archive also include some of the R script used to performed the analyses of the manuscrit:</p> <ul> <li> </li> <li><a href="https://zenodo.org/api/files/cd560cff-56d4-4f72-95be-e70939f2b85f/Population_genetic_Ark_analyses.R">Population_genetic_Ark_analyses.R </a>: Script to perform PCA +phenotypic cline + FST + Hobs + FIS</li> <li><a href="https://zenodo.org/api/files/cd560cff-56d4-4f72-95be-e70939f2b85f/Suspension_bridge_fit.R">Suspension_bridge_fit.R </a>: Script to perform the suspension bridge fit used to found evidence of gene flux inside the inversion.</li> <li><a href="https://zenodo.org/api/files/cd560cff-56d4-4f72-95be-e70939f2b85f/Cline_function.R">Cline_function.R </a>: function used to fit the allelic frequency variation (cline) along the transect</li> </ul> <p>The raw sequences are available in NCBI.</p> <p>Abstract of the study: Understanding the genetic targets of natural selection is one of the most challenging goalsof population genetics. Some of the earliest candidate genes were identified from associations between allozyme allele frequencies and environmental variation. One such example is the clinal polymorphism in the arginine kinase (<em>Ak</em>) gene in the marine snail <em>Littorina fabalis</em>. While other enzyme loci do not show differences in allozyme frequencies among populations, the <em>Ak</em> alleles are near differential fixation across repeated wave exposure gradients in Europe. Here, we use this case to illustrate how a new sequencing toolbox can be employed to characterize the genomic architecture associated with historical candidate genes. We found that the <em>Ak</em> alleles differ by 9 non-synonymous substitutions, which perfectly explain the different migration patterns of the allozymes during electrophoresis. Moreover, by exploring the genomic context of the <em>Ak</em> gene, we found that the three main <em>Ak</em> alleles are located on different arrangements of a putative chromosomal inversion that reaches near fixation at the opposing ends of two transects covering a wave exposure gradient. This shows <em>Ak</em> is part of a large (3/4 of the chromosome) genomic block of differentiation, in which <em>Ak</em> is unlikely to be the only target of divergent selection. Nevertheless, the non-synonymous substitutions among <em>Ak</em> alleles and the complete association of one allele with one inversion arrangement suggest that the <em>Ak</em> gene is a strong candidate to contribute to the adaptive significance of the inversion.</p> <p> </p> <p> </p>
Data from: Divergent population structure and climate associations of a chromosomal inversion polymorphism across the Mimulus guttatus species complex
Chromosomal rearrangement polymorphisms are common and increasingly found to be associated with adaptive ecological divergence and speciation. Rearrangements, such as inversions, reduce recombination in heterozygous individuals and thus can protect favorable allelic combinations at linked loci, facilitating their spread in the presence of gene flow. Recently, we identified a chromosomal inversion polymorphism that contributes to ecological adaptation and reproductive isolation between annual and perennial ecotypes of the yellow monkeyflower, Mimulus guttatus. Here we evaluate the population genetic structure of this inverted region in comparison with the collinear regions of the genome across the M. guttatus species complex. We tested whether annual and perennial M. guttatus exhibit different patterns of divergence for loci in the inverted and noninverted regions of the genome. We then evaluated whether there are contrasting climate associations with these genomic regions through redundancy analysis. We found that the inversion exhibits broadly different patterns of divergence among annual and perennial M. guttatus and is associated with environmental variation across population accessions. This study is the first widespread population genetic survey of the diversity of the M. guttatus species complex. Our findings contribute to a greater understanding of morphological, ecological, and genetic evolutionary divergence across this highly diverse group of closely related ecotypes and species. Finally, understanding species relationships among M. guttatus sp. has hitherto been stymied by accumulated evidence of substantial gene flow among populations as well as designated species. Nevertheless, our results shed light on these relationships and provide insight into adaptation in life history traits within the complex.
Data from: Divergent population structure and climate associations of a chromosomal inversion polymorphism across the Mimulus guttatus species complex
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Data from: Chromosome arm specific patterns of polymorphism associated with chromosomal inversions in the major African malaria vector, Anopheles funestus
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Data from: The adaptive significance of chromosomal inversion polymorphisms in Drosophila melanogaster
Chromosomal inversions, structural mutations that reverse a segment of a chromosome, cause suppression of recombination in the heterozygous state. Several studies have shown that inversion polymorphisms can form clines or fluctuate predictably in frequency over seasonal time spans. These observations prompted the hypothesis that chromosomal rearrangements might be subject to spatially and/or temporally varying selection. Here we review what has been learned about the adaptive significance of inversion polymorphisms in the vinegar fly Drosophila melanogaster, the species in which they were first discovered by Sturtevant in 1917. A large body of work provides compelling evidence that several inversions in this system are adaptive; however, the precise selective mechanisms that maintain them polymorphic in natural populations remain poorly understood. Recent advances in population genomics, modeling and functional genetics promise to greatly improve our understanding of this longstanding and fundamental problem in the near future.
Data from: The adaptive significance of chromosomal inversion polymorphisms in Drosophila melanogaster
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