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205 results for “Chronic Wounds”
Dataset for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing"
<p>Primary images, spreadsheets and files for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing"</p>
Effects of acute and chronic corticosterone treatments in the American Bullfrog wound healing
<p>Glucocorticoid (GC) release is triggered by adverse stimuli that activate hypothalamus-pituitary-adrenal/interrenal (HPA/I) axis. Glucocorticoids may enhance or suppress immune functions depending on the level of elevation. In this study, we investigated the effects of transient and chronic increases of CORT on the wound healing of the American bullfrog. Frogs were submitted to a daily transdermal hormonal application that acutely elevated CORT plasma levels, or vehicle as a control. Other frogs were surgically implanted with a silastic tube filled with CORT that resulted in chronic elevation of CORT plasma levels or received empty implants as a control. A dermal biopsy was performed to create a wound and was photographed every 3 days. Individuals treated with transdermal CORT started healing faster than their control 32 days after the biopsy. Frogs that received CORT implants tended to heal slower than control subjects. Plasma bacterial killing ability (BKA) was not affected by treatment, which reinforces the constitutive nature of this innate immune trait. By the end of the experiment, frogs from the acute CORT treatment had smaller wounds compared to those receiving the CORT-filled implants, highlighting the differential effects of acute (immunoenhancing) and chronic (immunosuppressive) elevation of CORT plasma levels.</p>
SNaP Wound Care System Versus Traditional NPWT Device for Treatment of Chronic Wounds
ClinicalTrials.gov study NCT00951080. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Real-World Registry of Chronic Wounds and Ulcers
ClinicalTrials.gov study NCT02280733. IPD Sharing: YES. Countries: 1. Publications: 6.
Evaluation of the Use of EZCare/V1STA in the Management of Acute and Chronic Wounds
ClinicalTrials.gov study NCT00994162. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Evaluation of the Effectiveness of Daily Pulse Lavage Therapy in Chronic Wounds
ClinicalTrials.gov study NCT01500746. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Feasibility Study of a Novel Device for Chronic Wounds
ClinicalTrials.gov study NCT00660049. IPD Sharing: NO. Countries: 1. Publications: 1.
Prontosan Quality of Life Study in Patients With Chronic Leg Wound(s)
ClinicalTrials.gov study NCT03369756. IPD Sharing: NO. Countries: 1. Publications: 7.
Cyclical Topical Wound Oxygen Therapy (TWO2) in the Treatment of Chronic Wounds
ClinicalTrials.gov study NCT04168905. IPD Sharing: YES. Countries: 1. Publications: 1.
Trial of Versajet Compared With Conventional Treatment in Acute and Chronic Wounds
ClinicalTrials.gov study NCT01050673. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy, Safety and Economic Benefits of Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers
ClinicalTrials.gov study NCT02326337. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Effects of acute and chronic corticosterone treatments in the American Bullfrog wound healing
Open the record for dataset details and reuse information.
The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection
<p>Opportunistic pathogens are associated with a number of chronic human infections, yet the evolution of virulence in these organisms during chronic infection remains poorly understood. Here, we tested the evolution of virulence in the human opportunistic pathogen Pseudomonas aeruginosa in a murine chronic wound model using a two-part serial passage and sepsis experiment, and found that virulence evolved in different directions in each line of evolution. We also assessed P. aeruginosa adaptation to a chronic wound after 42 days of evolution and found that morphological diversity in our evolved populations was limited compared to that previously described in cystic fibrosis (CF) infections. Using whole-genome sequencing, we found that genes previously implicated in P. aeruginosa pathogenesis (lasR, pilR, fleQ, rpoN and pvcA), contained mutations during the course of evolution in wounds, with selection occurring in parallel across all lines of evolution. Our findings highlight that (i) P. aeruginosa heterogeneity may be less extensive in chronic wounds than in CF lungs; (ii) genes involved in P. aeruginosa pathogenesis acquire mutations during chronic wound infection; (iii) similar genetic adaptations are employed by P. aeruginosa across multiple infection environments and (iv) current models of virulence may not adequately explain the diverging evolutionary trajectories observed in an opportunistic pathogen during chronic wound infection.</p>
Violet-Blue Light Inactivation of Bacteria in Chronic Wounds
ClinicalTrials.gov study NCT05739058. IPD Sharing: NO. Countries: 1. Publications: 9.
Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing
ClinicalTrials.gov study NCT02845466. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Trial Evaluating the Safety and Efficacy of the Use of Chitosan Gel in Patients With Chronic Wounds
ClinicalTrials.gov study NCT04178525. IPD Sharing: NO. Countries: 2. Publications: 1.
Chronic Wound Care of Lower Limb in M@diCICAT Center at CHU de Martinique
ClinicalTrials.gov study NCT05491291. IPD Sharing: NO. Countries: 1. Publications: 2.
Photodynamic Therapy With Hydrogel Dressing for Chronic Wounds
ClinicalTrials.gov study NCT06445699. IPD Sharing: NO. Countries: 1. Publications: 5.
Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome
ClinicalTrials.gov study NCT04437537. IPD Sharing: NO. Countries: 1. Publications: 4.
Defocused Shock Wave Therapy for Chronic Wounds
ClinicalTrials.gov study NCT02410447. IPD Sharing: Not stated. Countries: 1. Publications: 17.
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OpenNeuro
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