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ShareScore release 0.9.0
Dataset results
75 results for “Chronic airways disease”
Association Between Increased Oxidative Stress, Anti-Inflammatory Fatty Acid Formation, and Airway Infection in People With Asthma and Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00595114. IPD Sharing: Not stated. Countries: 1. Publications: 1.
To Evaluate the Effect of Inhaled Medication Together With Exercise and Activity Training on Exercise Capacity and Daily Activities in Patients With Chronic Lung Disease With Obstruction of Airways
ClinicalTrials.gov study NCT02085161. IPD Sharing: Not stated. Countries: 11. Publications: 2.
Effect on Structural Changes in Airways, Measured by MSCT, of Twice Daily 60mg AZD9668 for 12 Weeks in Chronic Obstructive Pulmonary Disease (COPD) Patients
ClinicalTrials.gov study NCT01054170. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases
ClinicalTrials.gov study NCT04765722. IPD Sharing: NO. Countries: 1. Publications: 10.
The lower airways microbiome and antimicrobial peptides in Idiopathic Pulmonary Fibrosis differ from Chronic Obstructive Pulmonary Disease
<p><strong>Background</strong>: The lower airways microbiome and host immune response in chronic pulmonary diseases are incompletely understood. We aimed to investigate possible microbiome characteristics and key antimicrobial peptides and proteins in idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).</p> <p><strong>Methods</strong>: 12 IPF patients, 12 COPD patients and 12 healthy controls were sampled with oral wash (OW), protected bronchoalveolar lavage (PBAL) and right lung protected sterile brushings (rPSB). The antimicrobial peptides and proteins (AMPs), secretory leucocyte protease inhibitor (SLPI) and human beta defensins 1 and 2 (hBD-1 & hBD-2), were measured in PBAL by enzyme linked immunosorbent assay (ELISA).</p> <p>The V3V4 region of the bacterial 16S rDNA gene was sequenced. Bioinformatic analyses were performed with QIIME 2.</p> <p><strong>Results</strong>: hBD-1 levels in PBAL for IPF were lower compared with COPD. The predominant phylae in IPF were <i>Firmicutes</i>, <i>Bacteroides</i> and <i>Actinobacteria</i>; <i>Proteobacteria</i> were among top three in COPD. Differential abundance analysis at genus level showed significant differences between study groups for less abundant, mostly oropharyngeal, microbes. Alpha diversity was lower in IPF in PBAL compared to COPD (p=0.03) and controls (p=0.01), as well as in rPSB compared to COPD (p=0.02) and controls (p=0.04). Phylogenetic beta diversity showed significantly more similarity for IPF compared with COPD and controls. There were no significant correlations between alpha diversity and AMPs.</p> <p><strong>Conclusions</strong>: IPF differed in microbial diversity from COPD and controls, accompanied by differences in antimicrobial peptides. Beta diversity similarity between OW and PBAL in IPF may indicate that microaspiration contributes to changes in its microbiome<b>.</b></p>
Airway Inflammation In Patients With Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00268177. IPD Sharing: YES. Countries: 8. Publications: 2.
Efficacy of Education Programs in Patients With Chronic Airway Diseases
ClinicalTrials.gov study NCT02827929. IPD Sharing: NO. Countries: 1. Publications: 4.
The Effect of Immediate Smoking Cessation Interventions for Smokers With Chronic Airway Diseases
ClinicalTrials.gov study NCT05764343. IPD Sharing: NO. Countries: 1. Publications: 5.
Does Extra-fine Hydrofluoroalkane-beclomethasone Dipropionate (HFA-BDP) Suppress Small Airways Inflammation in Chronic Obstructive Pulmonary Disease (COPD)?
ClinicalTrials.gov study NCT00921921. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessment of Risk in Chronic Airways Disease Evaluation
ClinicalTrials.gov study NCT01656421. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease
ClinicalTrials.gov study NCT00555607. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of High Dose N-acetylcysteine on Airtrapping and Airway Resistance in Chronic Obstructive Pulmonary Disease (COPD) Patients
ClinicalTrials.gov study NCT01136239. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cohort Study of Airway Microecology and the Pathogenesis and Evolution of Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT04849104. IPD Sharing: NO. Countries: 1. Publications: 21.
Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT00857038. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Using Continuous Positive Airway Pressure to Reduce the Incidence of Acute Kidney Injury in Hospitalized Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT01859260. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Effects of Nycthemeral Variations on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent in Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT01192932. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Association Between Handgrip Strength and Small Airway Disease in Patients with Stable Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT06223139. IPD Sharing: YES. Countries: 1. Publications: 1.
Biological Determinants of Sputum Rheology in Chronic Airway Diseases
ClinicalTrials.gov study NCT04081740. IPD Sharing: YES. Countries: 1. Publications: 1.
The lower airways microbiome and antimicrobial peptides in Idiopathic Pulmonary Fibrosis differ from Chronic Obstructive Pulmonary Disease
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Chronic Airway Disease and Multimorbidity Cohort
ClinicalTrials.gov study NCT06798077. IPD Sharing: NO. Countries: 1. Publications: 0.
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