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36 results for “Clinical Neurology”
Clinical Dataset for Artificial Intelligence-Driven Predictive Modeling for Home Discharge in Neurological and Orthopedic Conditions
<p><span>In recent years, the fusion of the medical and computer science domains has gained significant traction in the scientific research landscape. Progress in both fields has enabled the generation of a vast amount of data used for making predictions and identifying interesting clusters and pathways. The Machine Learning model's application in the medical domain is one of the most compelling and challenging topics to explore, bridging the gap between Artificial Intelligence (AI) and healthcare. The combination of AI and medical information offers the possibility to create tools that can benefit both healthcare providers and physicians. This enables the enhancement of rehabilitation therapy and patient care. In the rehabilitation context, this work provides an alternative perspective: prediction of patients’ home discharge upon completing the rehabilitation protocol. Demographic and clinical data were collected from electronic Medical Record. </span></p> <p><span>The original analysis dataset includes clinical and demographic data of adults admitted to the neurology and orthopedic departments of a rehabilitation hospital in Italy from January 2015 to August 2022. The completion of patients’ ADR-r form</span><span> resulted in the collection of data for 10520 individuals, whose information is distributed across 120 initial features. We anonymized dataset rows. Clinical data, including the primary reason for rehabilitation, any associated medical conditions, impairments, and admission/discharge mBi scores were collected. </span></p> <p><span>A legend file is enclosed to explain variable labels.</span></p>
Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions
ClinicalTrials.gov study NCT02091739. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disabili
ClinicalTrials.gov study NCT02270736. IPD Sharing: NO. Countries: 6. Publications: 2.
Health, Economic Analysis and Clinical Aspects of Patients With Neurological Disabilities in Enteral Nutrition With Dedicated Formula. The Role of Nissen's Fundoplication in the Management of Gastroes
ClinicalTrials.gov study NCT05068089. IPD Sharing: NO. Countries: 1. Publications: 6.
Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions
ClinicalTrials.gov study NCT01953523. IPD Sharing: YES. Countries: 1. Publications: 1.
Clinical Characteristics and Outcome of Patients with Hemorrhagic Stroke Admitted in Neurology Department in a Tertiary Hospital
ClinicalTrials.gov study NCT06824311. IPD Sharing: NO. Countries: 1. Publications: 3.
Clinical Evaluation of HRV Biofeedback in Functional Neurological Disorders Compared to Placebo
ClinicalTrials.gov study NCT06422819. IPD Sharing: NO. Countries: 1. Publications: 12.
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing
ClinicalTrials.gov study NCT04394871. IPD Sharing: NO. Countries: 1. Publications: 2.
Supplemental materials for: Implementation and evaluation of an objective structured clinical examination (OSCE) tool for neurology post-graduate trainees in Lusaka, Zambia
<p>Introduction: Despite the high burden of neurologic disease in Zambia, a low-middle income sub-Saharan African country of 18 million people, there are currently no Zambian neurologists. We established the first neurology residency program in Zambia at the University of Zambia School of Medicine and the University Teaching Hospital in Lusaka. We evaluated the feasibility and effectiveness of a modified Objective Structured Clinical Examination (OSCE) to assess clinical skills. </p> <p>Program Description: The neurology training program began in October 2018, and its 3 participants completed the OSCE exercise in February 2019. The exercise involved using a smartphone to videotape trainees performing a physical examination and oral presentation in the neurology clinic. Trainees and neurology faculty reviewed the videos independently and assessed performance using a standardized rubric. The faculty and trainee then met in person and discussed the activity and scoring rubric. </p> <p>Assessment & Outcomes: Three trainees completed pre- and post-OSCE surveys where they rated their confidence in elements of the history and neurological examination and provided feedback about the OSCE exercise. One faculty member reviewed each video and provided feedback to each trainee. Trainees' average self-confidence scores improved from the pre- to post-OSCE survey in every category (pre-OSCE: mean score 6.84, range 4.8-7.8, SD 0.92; post-OSCE: mean score 7.9, range 5.67-9.33, SD 0.86). Qualitative responses showed trainees found the OSCE helpful, routinely applied feedback, and would appreciate repeating OSCEs every few months. </p> <p>Lessons Learned: This study demonstrated that OSCEs can be modified and successfully implemented in a resource-limited neurology post-graduate training program and result in improved self-confidence among trainees. Important modifications to the OSCE involved using smartphones to videotape the OSCE's and a real patient encounter rather than a standardized patient. Because there are many neurology patients and few providers in Zambia, embedding the experience within a busy clinic day was practical, directly applicable, and at a lower opportunity cost. </p> <p>Future Directions: Future work should expand use of OSCEs both within the Zambian neurology residency program and non-neurology training programs. Including additional video reviewers could add to the validity of clinical skills assessment. Videos created could also be used for remote mentorship and teaching purposes.</p>
Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies
ClinicalTrials.gov study NCT03031938. IPD Sharing: YES. Countries: 1. Publications: 0.
Supplemental materials for: Implementation and evaluation of an objective structured clinical examination (OSCE) tool for neurology post-graduate trainees in Lusaka, Zambia
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Clinical course of neurologic adverse events associated with immune checkpoint inhibitors
<p>In the present dataset we collected clinical, demographic and outcome data of a large cohort of patients with neurological immune-related adverse events associated with immune check-point inhibitors. </p>
BIOMARKERS OF ATHEROGENESIS AND CLINICAL NEUROLOGICAL CHARACTERISTICS OF THE INTERNAL CAROTY ARTERY
<p><em><span>Atherosclerosis is a multifactorial and widespread process that underlies the development of cardiovascular and cerebrovascular diseases. Atherosclerotic damage of cerebral vessels is a long-term process that passes through several stages during its development, in particular, the "asymptomatic" stage. Considering that atherosclerotic damage of carotid arteries is widely important in the development of acute cerebrovascular disorders, atherosclerotic damage of internal carotid arteries in patients with asymptomatic stenosis was generally considered as a model of atherosclerosis in brachiocephalic arteries (BSA). In this article, clinical-neurological and dopplerographic indicators of the development of the atherosclerotic process in patients with asymptomatic stenosis of the carotid artery are evaluated.</span></em></p>
One comprehensive clinical neurologic examination is sufficient to declare brain death
<p>Objective: To fill the evidence gap on the value of a single (SBD) or dual brain death (DBD) exam by providing data on irreversibility of brain function, organ donation consent and transplantation </p> <p>Methods: 12-year tertiary hospital and organ procurement organization data on brain death (BD) were combined and outcomes, including consent rate for organ donation and organs recovered and transplanted after SBD and DBD were compared after multiple adjustments for co-variates </p> <p>Results: two-hundred sixty-six patients were declared BD, 122 after SBD and 144 after DBD. Time from event to BD declaration was longer by an average of 20.9 hours after DBD (p=0.003). Seventy-five (73%) families of patients with SBD and 86 (72%) with DBD consented for organ donation (p=0.79). The number of BD exams was not a predictor for consent. No patient regained brain function during the periods following BD. Patients with SBD were more likely to have at least one lung transplanted (p = 0.033). The number of organs transplanted was associated with the number of exams [beta coefficient, (95% CI) -0.5 (-0.97 to -0.02), p=0.044], along with age (for 5 year increase, -0.36 (-0.43 to -0.29), p<0.001) and PaO2 level (for 10 mmHg increase, 0.026 (0.008 to 0.044), p=0.005) and decreased as the elapsed time to BD declaration increased (p=0.019). </p> <p>Conclusions: A single neurologic examination to determine brain death is sufficient in patients with non-anoxic catastrophic brain injuries. A second examination is without additional yield in this group and its delay reduces the number of organs transplanted. </p>
Assessing Accuracy of Clinical Diagnosis and Lesion Location in Acute Neurological Deficits - How Good Are Neurologists?
ClinicalTrials.gov study NCT03009656. IPD Sharing: NO. Countries: 1. Publications: 0.
Clinical Applicantion of Multi-Tracer PET/MR Imaging in Neurological Disorders/Disease
ClinicalTrials.gov study NCT06092125. IPD Sharing: NO. Countries: 1. Publications: 0.
Early Neurological Clinical Recovery, 3 Months After Endovascular Treatment of an Acute Ischemic Stroke
ClinicalTrials.gov study NCT02879123. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Multi-center Clinical Study on the Diagnosis and Treatment Management of Rare Neurological Disease in Children
ClinicalTrials.gov study NCT03649919. IPD Sharing: YES. Countries: 1. Publications: 0.
Cognitive Neurology Unit Clinical Registry
ClinicalTrials.gov study NCT05925621. IPD Sharing: YES. Countries: 1. Publications: 0.
Correlation Between Clinical Neurological Biomarkers and Rehabilitation Outcome
ClinicalTrials.gov study NCT06805929. IPD Sharing: NO. Countries: 1. Publications: 0.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.