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424 results for “Clinical characteristics”
Dataset of Pedigree, genotypes, clinical and biochemical characteristics of families of Northeastern Mexico
<p>This dataset combines pedigree, genotypes, clinical and biochemical data of 37 families of Northeastern Mexico. Primary reference is the article:</p> <p>Gallardo‑Blanco, H.L., Villarreal‑Perez, J.Z., Cerda‑Flores, R.M., Figueroa, A., Sanchez‑Dominguez, C.N., Gutierrez‑Valverde, J.M. ... Martinez‑Garza, L.E. (2017). Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study. Experimental and Therapeutic Medicine, 13, 523-529. https://doi.org/10.3892/etm.2016.3990</p> <p><strong>If you use these data please cite the corresponding manuscript, which can be downloaded here:</strong></p> <p>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348709/</p> <p>https://www.spandidos-publications.com/10.3892/etm.2016.3990</p> <p>This dataset contains genotypes for the following SNPs:</p> <p>rs2986742</p> <p>rs4846051</p> <p>rs1801131</p> <p>rs1801133</p> <p>rs6541030</p> <p>rs12130799</p> <p>rs11208654</p> <p>rs1137100</p> <p>rs12405556</p> <p>rs3118378</p> <p>rs3737576</p> <p>rs10923931</p> <p>rs7554936</p> <p>rs3737787</p> <p>rs2516839</p> <p>rs1040404</p> <p>rs4670767</p> <p>rs7578597</p> <p>rs13400937</p> <p>rs10496971</p> <p>rs2627037</p> <p>rs1801262</p> <p>rs1569175</p> <p>rs2975760</p> <p>rs3792267</p> <p>rs10510228</p> <p>rs1801282</p> <p>rs3856806</p> <p>rs4955316</p> <p>rs9809104</p> <p>rs4607103</p> <p>rs6548616</p> <p>rs734873</p> <p>rs5400</p> <p>rs2030763</p> <p>rs4402960</p> <p>rs1513181</p> <p>rs9291090</p> <p>rs10010131</p> <p>rs10007810</p> <p>rs385194</p> <p>rs1799883</p> <p>rs2504853</p> <p>rs7754840</p> <p>rs7745461</p> <p>rs1800750</p> <p>rs1800629</p> <p>rs361525</p> <p>rs12200998</p> <p>rs2397060</p> <p>rs192655</p> <p>rs1044498</p> <p>rs4463276</p> <p>rs731257</p> <p>rs864745</p> <p>rs32314</p> <p>rs2330442</p> <p>rs4717865</p> <p>rs3173798</p> <p>rs10954737</p> <p>rs854555</p> <p>rs3917542</p> <p>rs662</p> <p>rs705308</p> <p>rs3943253</p> <p>rs751141</p> <p>rs1471939</p> <p>rs12544346</p> <p>rs13266634</p> <p>rs7844723</p> <p>rs2242103</p> <p>rs1408801</p> <p>rs10811661</p> <p>rs10511828</p> <p>rs12779790</p> <p>rs3793791</p> <p>rs4746136</p> <p>rs1111875</p> <p>rs10885390</p> <p>rs11196175</p> <p>rs7903146</p> <p>rs10885406</p> <p>rs12255372</p> <p>rs290487</p> <p>rs4918842</p> <p>rs2237892</p> <p>rs10839880</p> <p>rs1837606</p> <p>rs5210</p> <p>rs5218</p> <p>rs5219</p> <p>rs2946788</p> <p>rs11227699</p> <p>rs7930460</p> <p>rs1800849</p> <p>rs1387153</p> <p>rs948028</p> <p>rs2270031</p> <p>rs2416791</p> <p>rs7961581</p> <p>rs2070586</p> <p>rs1503767</p> <p>rs2269793</p> <p>rs8050136</p> <p>rs818386</p> <p>rs2966849</p> <p>rs1879488</p> <p>rs757210</p> <p>rs2033111</p> <p>rs11652805</p> <p>rs10512572</p> <p>rs2125345</p> <p>rs12946618</p> <p>rs12946115</p> <p>rs12950541</p> <p>rs1885088</p> <p>rs3907047</p> <p>rs2071023</p> <p>rs2833479</p> <p>rs2833483</p> <p>rs2300386</p> <p>rs2835370</p> <p>rs1296819</p> <p>rs1892848</p> <p>rs4821004</p> <p> </p>
Epidemiological and clinical characteristics predictive of ICU mortality of traumatic brain injury patients treated at a trauma reference hospital – A cohort study - Dataset
<p><strong>Dataset of a cohort whose summary is described below.</strong></p> <p><strong>ABSTRACT</strong></p> <p><strong>Background</strong>: Traumatic brain injury (TBI) has substantial physical, psychological, social and economic impacts, with high rates of morbidity and mortality. Considering its high incidence, the aim of this study was to identify epidemiological and clinical characteristics that predict mortality in patients hospitalized for TBI in intensive care units (ICUs). <strong>Methods</strong>: A retrospective cohort study was carried out with patients over 18 years old with TBI admitted to an ICU of a Brazilian trauma referral hospital between January 2012 and August 2019. TBI was compared with other traumas in terms of clinical characteristics of ICU admission and outcome. Univariate and multivariate analyses were used to estimate the odds ratio for mortality. <strong>Results</strong>: Of the 4816 patients included, 1114 had TBI, with a predominance of males (85.1%). Compared with patients with other traumas, patients with TBI had a lower mean age (45.3 ± 19.1 versus 57.1 ± 24.1 years, p < 0.001), higher median APACHE II (19 versus 15, p <0.001) and SOFA (6 versus 3, p < 0.001) scores, lower median Glasgow Coma Scale (GCS) score (10 versus 15, p < 0.001), higher median length of stay (7 days versus 4 days, p < 0.001) and higher mortality (27.6% versus 13.3%, p < 0.001). In the multivariate analysis, the predictors of mortality were older age (OR: 1.008 [1.002-1.015], p = 0.016), higher APACHE II score (OR: 1.180 [1.155-1.204], p < 0.001), lower GCS score for the first 24 hours (OR: 0.730 [0.700-0.760], p < 0.001), and greater number of brain injuries and presence of associated chest trauma (OR: 1.727 [1.192-2.501], p < 0.001). <strong>Conclusion</strong>: Patients admitted to the ICU for TBI were younger and had worse prognostic scores, longer hospital stays and higher mortality than those admitted to the ICU for other traumas. The independent predictors of mortality were advanced age, APACHE II score, first 24-hour GCS score, number of brain injuries and chest trauma.</p>
Clinical characteristics of patients hospitalized for ocular chemical injuries in Shanghai from 2012 to 2017
Objective: To summarize the clinical characteristics of patients with ocular chemical injuries and evaluate their potential relationship with the visual outcome by analyzing the medical records of these patients from January 1, 2012, to December 31, 2017. Design: A retrospective case series study. Setting: Jinshan Hospital of Fudan University in Shanghai. Methods: Patient data included age, gender, occupational classification, location of ocular chemical injury, initial and final best-corrected distance visual acuity (BCDVA), intraocular pressure (IOP), nature and chemical phase, distribution and severity of chemical injury, management methods, and complications. All variables were evaluated for their potential relationship with visual outcome. Results: A total of 160 patients were hospitalized with ocular chemical injuries. The majority of the patients were factory workers and arrived at the consultation room less than 24 hours after injury. The most common ocular injury setting, classification of severity, causative chemical, chemical phase, and complications were workplace, grade Ⅱ, unknown and mixed substance, liquid, and elevated IOP, respectively. Initial BCDVA was significantly worse in the solid group than in the liquid group (P = 0.009). The risk factors for poor final BCDVA were identified as older age, poor initial BCDVA, and irrigation 24 hours after injury (P < 0.001, P < 0.001, and P = 0.011, respectively). Conclusion: We elaborate the clinical characteristics and outcomes of patients with ocular chemical injuries in Jinshan District, Shanghai. A comprehensive education program should be established and the use of protective eyewear should be promoted to prevent occupation-related ocular chemical injuries.
Development of a prognostic model for early breast cancer integrating neutrophil to lymphocyte ratio and clinical-pathological characteristics
<p><strong>Abstract</strong></p> <p>Breast cancer-related inflammation is critical in tumorigenesis, cancer progression, and patient prognosis. Several inflammatory markers derived from peripheral blood cells count, such as the neutrophil-lymphocyte ratio (NLR), derived neutrophil-lymphocyte ratio (dNLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII) are considered as prognostic markers in several types of malignancy. Here, we investigate and validate a prognostic model in early breast cancer (eBC) patients to predict disease-free survival (DFS) based on readily available baseline clinicopathological prognostic factors and preoperative peripheral blood-derived indexes. We analyzed a training cohort of 710 BC patients and two external validation cohorts of 980 and 157 eBC patients, respectively, with different demographic origins. An elevated preoperative NLR is a better DFS predictor than PLR, MLR, and SII in patients with eBC. The prognostic model generated in this study was able to classify patients into three groups with different risks of relapse based on ECOG-PS, presence of comorbidities, T and N stage, PgR status, and NLR. Prognostic models derived from the combination of clinicopathological features and peripheral blood indices, such as NLR, represent attractive markers mainly because they are easily detectable and applicable in daily clinical practice. More comprehensive prospective studies are needed to unveil their actual effectiveness.</p>
Dataset for a study:Clinical characteristics of SARS-CoV-2 delta variant infection in Xiamen
<p>This retrospective study aims to identify the clinical and demographic features of patients infected with the SARS-CoV-2 delta variant at a single institution in Xiamen, China.</p>
Clinical Characteristics and Microbiology of Healthcare Associated Pneumonia
ClinicalTrials.gov study NCT01966796. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Patient Characteristics, Treatment Patterns, and Clinical Outcomes in Patients Diagnosed With HR+/HER2 Advanced/Metastatic Breast Cancer on Palbociclib + Aromatase Inhibitor (AI) Combination Therapy
ClinicalTrials.gov study NCT04394247. IPD Sharing: NO. Countries: 1. Publications: 1.
Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19
ClinicalTrials.gov study NCT04706533. IPD Sharing: NO. Countries: 1. Publications: 19.
Clinical Characteristics, Frailty, and Prognostic Predictors in Patients Aged 75 and Older With Acute Coronary Syndrome
ClinicalTrials.gov study NCT07366684. IPD Sharing: YES. Countries: 1. Publications: 5.
Phase I Clinical Trial for Comparison of Pharmacokinetic Characteristics of Vorico Injection 200mg(Voriconazole) and Vfend® IV 200mg for Single Dose Crossover Intravenous Infusion in Healthy Volunteer
ClinicalTrials.gov study NCT02631954. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Analysis of the Interaction Between Preoperative Lifestyle and Clinical Characteristics of Cardiac Surgery Patients and Perioperative Complications
ClinicalTrials.gov study NCT06991218. IPD Sharing: NO. Countries: 1. Publications: 4.
Epidemiology, Immunology and Clinical Characteristics of COVID-19 (EPIC3)
ClinicalTrials.gov study NCT05764083. IPD Sharing: YES. Countries: 1. Publications: 3.
Study to Evaluate the Incidence, Clinical Characteristics and Economic Burden of Dengue in Brazilian Children
ClinicalTrials.gov study NCT01391819. IPD Sharing: NO. Countries: 1. Publications: 1.
Prospective Observational Study to Describe Characteristics and Management of Patients Treated With Denosumab (Prolia®) in Routine Clinical Practice
ClinicalTrials.gov study NCT01652690. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Clinical and Neurophysiological Characteristics of Narcolepsy
ClinicalTrials.gov study NCT05375890. IPD Sharing: YES. Countries: 1. Publications: 2.
A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remissi
ClinicalTrials.gov study NCT02198651. IPD Sharing: YES. Countries: 14. Publications: 2.
Clinical characteristics of patients hospitalized for ocular chemical injuries in Shanghai from 2012 to 2017
Open the record for dataset details and reuse information.
Data from: Clinical characteristics and lipid lowering treatment of patients initiated on Proprotein convertase subtilisin/kexin type 9 inhibitors – a nationwide cohort study
Objectives: Given the novelty of proprotein convertase subtilisin–kexin type 9 inhibitors (PCSK9i), little is known regarding overall implementation or clinical characteristics among patients who initiate treatment. We aimed to assess the total number of patients initiated on PCSK9i along with a description of the clinical characteristics and lipid lowering treatment (LLT) of such patients. Setting: A register based descriptive cohort study of patients receiving a PCSK9i in the time period from 01-01-2016 to 31-03-2017 using a cross-linkage between three nationwide Danish registers. Information regarding PCSK9i prescriptions, patient demographics, concurrent pharmacotherapy, comorbidities, and previous coronary procedures was identified. Results: Overall, 137 patients initiated treatment with PCSK9i in the study period from 11 in the first quarter of 2016 to 40 in the first quarter of 2017. The majority had a history of ischemic heart disease (67.9%) with ischemic stroke and diabetes mellitus being present in 7.3% and 16.8% of patients, respectively. All patients initiated on PCSK9i had been previous prescribed statin treatment with Atorvastatin and Simvastatin being most frequently prescribed in 53% and 36% of patients, respectively. The majority of patients had received both statins and Ezetimibe (94.9%) and approximately half of these patients had also received bile acid sequestrant (45.3%). Clinical characteristics mainly differed in patients receiving triple LLT compared to patients not receiving triple LLT in the regards of heart failure. Conclusion: Patients treated with PCSK9i were rare, characterized by having ischemic heart disease and had received various and intensive conventional LLT prior to PCSK9i initiation in agreement with current international guidelines.
Clinical, technical, and implementation characteristics of real-world health applications using FHIR
<p>Fast Healthcare Interoperability Resources (FHIR) has received vast support globally, with a growing number of use cases implemented throughout various healthcare settings. To assess the use of real-world FHIR applications (apps) implemented in practice, we distributed an electronic survey to FHIR developers and implementers. The data includes characteristics of 112 FHIR apps, including health domain, target audience, terminologies, FHIR specifications, implementation details, and types of organizations developing with FHIR. This repository includes the survey dataset and survey codebook.</p>
Radix Sophorae flavescentis for chronic hepatitis B - Characteristics of potential randomised clinical trials
<p>This table listed the references considered to be potential randomised clinical trials on Radix Sophorae flavescentis for chronic hepatitis B, as we could not attain any response from the authors about their randomisation method. We also listed the results of contacting authors. </p> <p> </p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.