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25 results for “Clostridium perfringens”
Dataset Dynamics of Clostridium perfringens in BSF production process
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Validation and Stabilization of a Prophage Lysin of Clostridium perfringens by Using Yeast Surface Display and Coevolutionary Models
<p>Bacteriophage lysins are compelling antimicrobial proteins whose biotechnological utility and evolvability would be aided by elevated stability. Lysin catalytic domains, which evolved as modular entities distinct from cell wall binding domains, can be classified into one of several families with highly conserved structure and function, many of which contain thousands of annotated homologous sequences. Motivated by the quality of these evolutionary data, the performance of generative protein models incorporating coevolutionary information was analyzed to predict the stability of variants in a collection of 9,749 multimutants across 10 libraries diversified at different regions of a putative lysin from a prophage region of a Clostridium perfringens genome. Protein stability was assessed via a yeast surface display assay with accompanying highthroughput sequencing. Statistical fitness of mutant sequences, derived from secondorder Potts models inferred with different levels of sequence homolog information, was predictive of experimental stability with areas under the curve (AUCs) ranging from 0.78 to 0.85. To extract an experimentally derived model of stability, a logistic model with site-wise score contributions was regressed on the collection of multimutants. This achieved a cross-validated classification performance of 0.95. Using this experimentally derived model, 5 designs incorporating 5 or 6 mutations from multiple libraries were constructed. All designs retained enzymatic activity, with 4 of 5 increasing the melting temperature and with the highest-performing design achieving an improvement of 4°C.</p>
VirR and RevR regulate many Clostridium perfringens genes in a reciprocal manner
GEO Series GSE72137. Clostridium perfringens. 6 samples. Type: Expression profiling by high throughput sequencing.
Epsilon Toxin-Producing Clostridium perfringens within the MS Gut Microbiome and Epsilon Toxin Function on Immune Privilege
GEO Series GSE223137. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Regulation of sialidase production in clostridium perfringens by the orphan sensor histidine kinase ReeS
GEO Series GSE36786. Clostridium perfringens str. 13. 4 samples. Type: Expression profiling by array.
Comparison of wildtype and agrB-null mutant Type A Clostridium perfringens strain CP1
GEO Series GSE97874. Clostridium perfringens. 3 samples. Type: Expression profiling by array.
Genome-wide transcriptional changes in the Clostridium perfringens-afflicted chicken intestine in an avian necrotic enteritis (NE) disease model
GEO Series GSE51154. Gallus gallus. 4 samples. Type: Expression profiling by array.
Comparative transcriptome analysis by RNAseq of Necrotic Enteritis Clostridium perfringens in ligated intestinal chicken loops and in vitro conditions.
GEO Series GSE79456. Clostridium perfringens. 4 samples. Type: Expression profiling by high throughput sequencing.
Effect of VirR/VirS-VR-RNA regulatory cascade on the expression of chromosomal genes of Clostridium perfringens
GEO Series GSE12833. Clostridium perfringens str. 13. 6 samples. Type: Expression profiling by array.
Transcriptome of a malO deletion mutant of Clostridium perfringens during stationary phase growth.
GEO Series GSE28699. Clostridium perfringens str. 13. 4 samples. Type: Expression profiling by array.
Simultaneous host-pathogen transcriptional analysis of Clostridium perfringens murine myonecrosis infections
GEO Series GSE106657. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of virX regulator on the expression of chromosomal genes of Clostridium perfringens
GEO Series GSE37998. Clostridium perfringens str. 13. 4 samples. Type: Expression profiling by array.
Analyses of long non-coding RNA and mRNA profiling in the spleen of diarrhea piglets caused by Clostridium perfringens type C
GEO Series GSE105797. Sus scrofa. 15 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Transcritptome of a revR deletion mutant during Clostridium perfringens exponential phase growth.
GEO Series GSE26508. Clostridium perfringens str. 13. 4 samples. Type: Expression profiling by array.
The transcriptional profile of deoxycholate-induced sporulation in Clostridium perfringens food poisoning isolate
GEO Series GSE69649. Clostridium perfringens; Clostridium perfringens NCTC 8239. 48 samples. Type: Expression profiling by array.
Transcriptional Profiling Analysis of Host response to Clostridium perfringens Infection in Broilers
GEO Series GSE13085. Gallus gallus. 23 samples. Type: Expression profiling by array.
Large-scale differences in gene expression, including genes encoding type IV pili-associated proteins, are seen when Clostridium perfringens is grown in liquid or on surfaces
GEO Series GSE99224. Clostridium perfringens. 12 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Transcriptome analysis of the opportunist pathogenic bacterium Clostridium perfringens ATCC 13124 grown in the presence of host polysaccharide hyaluronic acid and mucin
GEO Series GSE240236. Clostridium perfringens ATCC 13124. 3 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of Clostridium Perfringens infection in broilers on medicated and non-medicated diets.
GEO Series GSE14759. Gallus gallus. 20 samples. Type: Expression profiling by array.
Comparative genomic hybridization analysis shows different epidemiology of chromosomal and plasmid-borne cpe-carrying Clostridium perfringens type A strains
GEO Series GSE30954. Clostridium perfringens. 163 samples. Type: Genome variation profiling by array.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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