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9
datasets available to search
ShareScore release 0.9.0
Dataset results
9 results for “Compound mutations”
Clinical and Molecular Analysis in Two Families with Novel Compound Heterozygous SBP2 (SECISBP2) Mutations
Open the record for dataset details and reuse information.
High-throughput identification of the impact of ΔrecA mutation on sensitivities to various chemical compounds in Escherichia coli
GEO Series GSE121218. Escherichia coli. 6 samples. Type: Expression profiling by array.
Compound heterozygous mutations in the noncoding RNU4ATAC gene affect the homeostasis and function of the Integrator complex
GEO Series GSE197344. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Lifespan and healthspan benefits of FW1256, a novel hydrogen sulfide donor compound, in C. elegans are independent from effects downstream of eat-2 mutation
GEO Series GSE146412. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
Correction of splicing defect in compound heterozygous FRDA patient carrying FXN 165+5G>C point mutation.
GEO Series GSE262763. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome
GEO Series GSE106752. Venezuelan equine encephalitis virus. 13 samples. Type: Other.
Compound mutations in HRC and MYBPC3 synergistically increase cardiac pathogenicity
GEO Series GSE279737. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA-sequencing analysis of colon RNA from mice with compound mutations of XBP1, caspase-8, TNFR1 and MLKL.
GEO Series GSE244320. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Uncommon single and compound EGFR mutations: clinical outcomes of a heterogeneous subgroup of NSCLC "
<p>This record contains raw data related to article “Uncommon single and compound EGFR mutations: clinical outcomes of a heterogeneous subgroup of NSCLC"</p> <p>Molecular characterization of non-small-cell lung cancer (NSCLC) is essential to define the correct therapeutic algorithm in metastatic disease. Approximately 90% of epidermal growth factor receptor (EGFR) mutations are usually associated with sensitivity to EGFR tyrosine kinase inhibitors (TKIs). The remaining 10% defines a small, extremely heterogeneous subgroup of mutations, with a varied profile of sensitivity and response to target therapies.This retrospective observational study includes 47 patients affected by metastatic NSCLC harboring uncommon EGFR mutations (single or compound mutation). Patients were treated with EGFR-targeting TKIs or platinum-based chemotherapy as first-line treatment.Median OS resulted longer in the compound mutation group when compared to single rare mutations (33.6 vs 12 months; P = 0.473); a similar result was observed for PFS (16 vs 7.6 months; P = 0.281), although statistical significance was not reached. ORR, PFS and OS resulted similar for patients treated with first-line EGFR TKIs or chemotherapy. No difference in terms of PFS and OS was found according to the TKI administered.Compound mutations seem to be a good prognostic indicator for OS; they are also predictive of response to 1st and 2nd generation EGFR TKIs, as well as exon 19 insertions and mutations in codon 719 of exon 18. For mutations in exon 18 (not in codon 719) and exon 20 insertions, chemotherapy seems the most effective available option. The addition of immunotherapy to chemotherapy could change this approach in the next future.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.