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Dataset results
29 results for “Corpus Callosum”
Study Comparing Corpus Callosum Atrophy as a Marker of Later Development of Cognitive Impairment in Patients With Multiple Sclerosis
ClinicalTrials.gov study NCT01250665. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Infants With Agenesis of the Corpus Callosum
ClinicalTrials.gov study NCT02267161. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Geometric morphometrics reveal altered corpus callosum shape in pyridoxine-dependent epilepsy
Objective: To evaluate the features and maturational changes in overall callosal shape in patients with pyridoxine-dependent epilepsy (PDE). Methods: Measurements were conducted through landmark based geometric morphometrics applied on cerebral MRIs of PDE patients and age-matched control subjects. The outline of the corpus callosum was manually traced in the midsagittal plane. 300 semi-landmarks along the outline were collected and underwent statistical generalized Procrustes analysis. An allometric regression was applied to evaluate the callosal shape due to growth over time. Results: 38 patients with PDE and 38 age- and sex-matched control subjects were included. Mean age at the time of the MRI in the patient group was 9.3 years (median 6.3 years, range 0.01- 48 years). Significant differences (p<0.01) in the mean callosal shape between patients and controls were found. The allometric regression model revealed significant shape variations (p<0.01) between the two study groups across the developmental course after controlling for the effect of callosal size on shape. This latter effect turned out to be significant as well (p<0.001). Conclusions: Patients with PDE show an altered callosal shape and variations in callosal ontogeny which are likely secondary to the underlying genetic defect with abnormal function of antiquitin, the product of the ALDH7A1 gene.
Gene alterations, clinical informations and survival data of gliomas with/without corpus callosum involvement
<p>The raw dataset of this study contained the gene alterations, clinical informations and survival data of glioma patients. Gene alterations data were obtained by Next-generation DNA sequencing of glioma samples of patients. Clinical informations were obtained from Electronic medical records and follow-up. The survival data were obtained by follow-up of patients. In order to explore gene alterations and their correlation with the survival of glioblastoma (GBM) of corpus callosum (CC) involvement (ccGBM), this dataset was analyzed in detail. A total of<b> </b>30 ccGBM and 88 non-ccGBM were finally included. The ccGBM had higher incidence of <i>PDGFRA </i>(33.3% versus 9.1%, P=0.004) alterations than non-ccGBM. <i>PDGFRA </i>amplification (<i>PDGFRAamp</i>, 33.3% versus 9.1%, P=0.004) and missense mutation (<i>PDGFRAmut</i>, 20.0% versus 3.4%, P=0.011) both had higher incidence in ccGBM than in non-ccGBM. <i>PDGFRA </i>alteration was significantly associated with the occurrence of ccGBM (OR=4.91 [95%CI: 1.55-15.52], P=0.007). The ccGBM of <i>PDGFRAamp </i>achieved shorter median PFS (8.6 versus 13.5 months, P=0.025) and OS (12.4 versus 17.9 months, P=0.022) than non-ccGBM of <i>PDGFRAnon-amp</i>. The ccGBM of <i>PDGFRAamp</i> combined with <i>PDGFRAmut</i> (<i>PDGFRAamp-mut</i>)<i> </i>had shorter median PFS (7.6 versus 8.9 months, P=0.022) and OS (9.6 versus 17.8 months, P=0.006) than non-ccGBM of <i>PDGFRA</i> wild type and non-amplification (<i>PDGFRA-w, non-amp</i>). Compared to ccGBM of <i>PDGFRA-w, non-amp</i>, the ccGBM of <i>PDGFRAamp</i> and <i>PDGFRAamp-mut </i>both had shorter median PFS and OS (P<0.05). Hazard ratios (HRs) of <i>PDGFRAamp</i> for PFS and OS of ccGBM were 3.08 (95%CI: 1.02-9.35, P=0.047) and 5.07 (95%CI: 1.52-16.89, P=0.008) respectively, HRs of <i>PDGFRAamp-mut </i>for PFS and OS were 13.16 (95%CI: 3.19-54.40, P<0.001) and 16.36 (95%CI: 2.66-100.70, P=0.003) respectively. The <i>PDGFRA </i>alterations is significantly associated with the occurrence and poor prognosis of ccGBM.</p>
Gene alterations, clinical informations and survival data of gliomas with/without corpus callosum involvement
Open the record for dataset details and reuse information.
Data from: Geometric morphometrics reveal altered corpus callosum shape in pyridoxine-dependent epilepsy
Open the record for dataset details and reuse information.
Gene expression profiles from corpus callosum brain tissue obtained from cuprizone-treated mice
GEO Series GSE100663. Mus musculus. 16 samples. Type: Expression profiling by array.
RNAseq of mouse corpus callosum from WT or TRPA1-KO animals under chronic cerebral hypoperfusion
GEO Series GSE201513. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA profiling of demyelination and remyelination areas in corpus callosum of cuprizone-treated mice
GEO Series GSE100662. Mus musculus. 14 samples. Type: Non-coding RNA profiling by array.
Transcription factor 4 regulates the interhemispheric midline remodeling through neuron–astroglia communications during corpus callosum formation
GEO Series GSE298404. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Expression data from amoeboid and ramified microglia isolated from the corpus callosum of 5-day and 4-week old rat brain
GEO Series GSE29885. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
scRNAseq of Mertk-WT and Mertk-KO corpus callosum
GEO Series GSE148676. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Bulk RNAseq of AnnexinV+ and AnnexinV- cells from the Mertk-KO corpus callosum at the 4 week cuprizone timepoint
GEO Series GSE148677. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum
GEO Series GSE231546. Homo sapiens. 25 samples. Type: Expression profiling by high throughput sequencing.
Corpus Callosum Agenesis and Intellectual Disability
ClinicalTrials.gov study NCT02167568. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Frequency and Type of Genetic Abnormalities Found in Antenatal Corpus Callosum Malformation
ClinicalTrials.gov study NCT03680651. IPD Sharing: Not stated. Countries: 1. Publications: 0.
BECOME CHILDREN OF HOLDERS Corpus Callosum Agenesis Screened IN PERIOD Antenatal
ClinicalTrials.gov study NCT02826824. IPD Sharing: NO. Countries: 1. Publications: 0.
Whole Exome Sequencing in Prenatal Diagnosis of Agenesis of the Corpus Callosum
ClinicalTrials.gov study NCT03600792. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Functional Implication of Corpus Callosum in Voluntary Strength in COPD Patients
ClinicalTrials.gov study NCT03807258. IPD Sharing: NO. Countries: 1. Publications: 0.
RNA-seq profiles of WT and Qk-KO corpus callosum and oligodendrocytes
GEO Series GSE106468. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.