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215 results for “Cryoablation”
RNAseq transcriptome of draining lymph node (LN) and tumor of MC38 murine tumors treated with cryoablation and chitosan/IL-12
<p class="MsoNormal">Focal ablation technologies are routinely used in the clinical management of inoperable solid tumors but often result in incomplete ablations leading to high recurrence rates. Adjuvant therapies capable of safely eliminating residual tumor cells are therefore of great clinical interest. Interleukin 12 (IL-12) is a potent antitumor cytokine that can be localized intratumorally through coformulation with <span>viscous biopolymers</span> including chitosan (CS) solutions. The objective of this research was to determine if localized immunotherapy with CS/IL-12 could prevent <span>tumor recurrence after cryoablation (CA). Tumor recurrence, overall survival, and protective immunity were assessed. Systemic immunity was evaluated in spontaneously metastatic and bilateral tumor models. Temporal bulk RNA sequencing was performed on tumor and draining lymph node samples.</span> In multiple murine tumor models, the addition of CS/IL-12 to CA reduced recurrence rates by 30–55%. Altogether, this cryo-immunotherapy induced complete durable regression of large tumors in 80–100% of treated animals. <span>Mice</span> treated with CA plus adjuvant CS/IL-12 were partially or completely protected from tumor rechallenge. <span>Systemically,</span> CS/IL-12 prevented lung metastases when delivered as a neoadjuvant to CA. However, CA plus CS/IL-12 had minimal antitumor activity against established, untreated abscopal tumors. Adjuvant anti-PD-1 therapy delayed the growth of abscopal tumors. Transcriptome analyses revealed early immunological changes in <span>the dLN</span>, followed by a significant increase in gene expression associated with immune suppression and regulation. Cryo-immunotherapy with localized CS/IL-12<span> reduces recurrences and</span> enhances the elimination of large primary tumors<span>. This focal combination therapy also induces significant systemic</span> antitumor immunity <span>although further studies are necessary</span>.</p>
A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation
ClinicalTrials.gov study NCT00523978. IPD Sharing: Not stated. Countries: 2. Publications: 1.
CryoCath Freezor CryoAblation Catheter System (CRYOFACTS)
ClinicalTrials.gov study NCT00621621. IPD Sharing: Not stated. Countries: 1. Publications: 1.
POLARx Cardiac Cryoablation System Study
ClinicalTrials.gov study NCT04250714. IPD Sharing: Not stated. Countries: 7. Publications: 2.
Cryoablation Therapy in Treating Patients With Invasive Ductal Breast Cancer
ClinicalTrials.gov study NCT00723294. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tracking Renal Tumors After Cryoablation Evaluation
ClinicalTrials.gov study NCT01117779. IPD Sharing: NO. Countries: 1. Publications: 6.
Cryoablation of Bone Metastases From Endocrine Tumors
ClinicalTrials.gov study NCT03986593. IPD Sharing: YES. Countries: 1. Publications: 6.
Cryoablation System FIM/CE Mark Study
ClinicalTrials.gov study NCT03723070. IPD Sharing: NO. Countries: 3. Publications: 2.
AlloStim® Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer
ClinicalTrials.gov study NCT02380443. IPD Sharing: NO. Countries: 1. Publications: 8.
Intracardiac CrYoablation for AtrioVentricular Nodal Reentrant Tachycardia
ClinicalTrials.gov study NCT01426425. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases
ClinicalTrials.gov study NCT02511678. IPD Sharing: NO. Countries: 2. Publications: 39.
Study of Cryoablation for Metastatic Lung Tumors
ClinicalTrials.gov study NCT01957787. IPD Sharing: NO. Countries: 2. Publications: 8.
Early Percutaneous Cryoablation for Pain Control After Rib Fractures Among Elderly Patients
ClinicalTrials.gov study NCT04482582. IPD Sharing: NO. Countries: 1. Publications: 37.
Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With Metastatic Sarcoma Stable on Chemotherapy
ClinicalTrials.gov study NCT01986829. IPD Sharing: NO. Countries: 1. Publications: 1.
Two and Three Dimensional Contrast-enhanced Ultrasound for Screening of Renal Cell Carcinoma Recurrence Following Cryoablation
ClinicalTrials.gov study NCT02440334. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy of Cryoablation for Metastatic Lung Tumors
ClinicalTrials.gov study NCT01307501. IPD Sharing: NO. Countries: 2. Publications: 7.
Cryoablation of Low Risk Small Breast Cancer- ICE3 Trial
ClinicalTrials.gov study NCT02200705. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cryoablation of AF: Improving the Use of the Achieve Catheter
ClinicalTrials.gov study NCT01843465. IPD Sharing: Not stated. Countries: 1. Publications: 1.
RNAseq transcriptome of draining lymph node (LN) and tumor of MC38 murine tumors treated with cryoablation and chitosan/IL-12
Open the record for dataset details and reuse information.
iCLAS™ Cryoablation System Post-Market Clinical Follow-up (PMCF) Study
ClinicalTrials.gov study NCT05416086. IPD Sharing: NO. Countries: 3. Publications: 0.
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