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13 results for “Cyanoacrylate glue”

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zenodo36/100

Cyanoacrylate glue in breast surgery: the GLUBREAST Trial Can cyanoacrylate glue reduce seroma after axillary dissection?

<p>In 2018, the National Cancer Institute of Naples has launched the GLUBREAST Trial to verify the efficacy of cyanoacrylate sealing glue to reduce seroma after axillary dissection in breast surgery. The glue is a synthetic sealant, CE approved for internal human uses and surgical procedures. The assumed mechanism of action in breast surgery is that the glue create a seal coating in the operative field to occlude lymphatic leaks and limit seroma formation. Methods The trial included one hundred-eighty patients scheduled for breast conserving surgery or total mastectomy without reconstruction.Ninety-one were randomized to receive suction drain and sealant glue after axillary dissection (Experimental Arm), whereas eighty-nine patients (Control Arm) received suction drain without glue. Statistics A multivariable mixed effect model on presence of liquid drained and volume drained were calculated.&nbsp;Stratified models by visits were performed. Results The trial ended in June 2022. Older age was associated with a higher volume&nbsp;of seroma drained per day (&beta; 0.30; 95% CI: 0.00‐0.60). 5‐U increase in Body Mass Index was associated with higher daily drained&nbsp;seroma volume in patients underwent breast conserving surgery (&beta; 5.0; 95% CI: 0.62‐9.4), but not in patients underwent<br>mastectomy (&beta; 2.5; 95% CI: ‐3.6‐8.6). We did not find statistically significant differences in presence of liquid drained and volume<br>drained among the study groups. An advantage for the Experimental Arm was observed from 3 th and 4 th to 5 th outpatient<br>visits without reaching a statistical significance (p=0.069 and p=0.072, respectively), so far 5% of patients in the Experimental<br>Group had clinical benefit from the glue.Conclusions. Data in the literature come from case series, and surgeons need higher level<br>of evidence to drive surgical decision-making and choose proper devices to increase patient quality of life. GLUBREAST randomized&nbsp;trial tested the efficacy of cyanoacrylate sealing glue to prevent post-operative seroma in breast surgery. Although only a small&nbsp;number of patients benefited from sealant application, we regret to say this trial has some limitation, i.e. the prolonged presence&nbsp;of suction drain. Further research is warranted to better clarify the benefit of cyanoacrylate glue in breast surgery.</p>

opencc-by-4.0Jul 2024View details →
ClinicalTrials.gov36/100

Impact of Cyanoacrylate Glue on PICC Line Dressing Care

ClinicalTrials.gov study NCT05246709. IPD Sharing: YES. Countries: 1. Publications: 6.

controlledIPD-YESFeb 2026View details →
ClinicalTrials.gov36/100

Tissue Glue (Cyanoacrylate) Versus Conventional Suture in Kidney Donors

ClinicalTrials.gov study NCT01521871. IPD Sharing: Not stated. Countries: 1. Publications: 4.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov32/100

Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas

ClinicalTrials.gov study NCT07155525. IPD Sharing: NO. Countries: 1. Publications: 2.

closedIPD-NOFeb 2026View details →
ClinicalTrials.gov32/100

Effectiveness of Cyanoacrylate Glue in the Fixation of Midline and Peripherally Inserted Central Catheters in Hospitalized Adult Patients: Randomised Clinical Trial (CIANO-ETI)

ClinicalTrials.gov study NCT05299060. IPD Sharing: YES. Countries: 1. Publications: 26.

controlledIPD-YESFeb 2026View details →
ClinicalTrials.gov32/100

Fixation of Skin Grafts in Patients With Burns: Comparison Between Cyanoacrylate Glue and Skin Staples

ClinicalTrials.gov study NCT00363558. IPD Sharing: Not stated. Countries: 1. Publications: 3.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov32/100

Feasibility and Tolerance Study for the Treatment of Varicose Ulcers by Cyanoacrylate Glue (ETUVVE)

ClinicalTrials.gov study NCT04714749. IPD Sharing: NO. Countries: 1. Publications: 10.

closedIPD-NOFeb 2026View details →
ClinicalTrials.gov28/100

Trial Investigating Cyanoacrylate Glue to Prevent Surgical Site Infection Following Breast Surgery

ClinicalTrials.gov study NCT02779296. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov28/100

Dressing Versus Glue (2-Octyl Cyanoacrylate) for Coverage of the Skin Incision After Closure During Cesarean Delivery

ClinicalTrials.gov study NCT02323711. IPD Sharing: Not stated. Countries: 0. Publications: 8.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov24/100

Immediately Placed Implant Sealed With Platelets Rich Fibrin Versus Cyanoacrylate Glue

ClinicalTrials.gov study NCT05437744. IPD Sharing: Not stated. Countries: 1. Publications: 0.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov24/100

Sutured Versus Cyanoacrylate Glue Mesh Fixation for Inguinal Hernia Repair

ClinicalTrials.gov study NCT04203940. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov24/100

Study Comparing the Efficacy of Peripherally Inserted Central Catheter (PICC) Placement With the Addition of Cyanoacrylate Glue Versus PICC Placement Alone in Patients With Cancer.

ClinicalTrials.gov study NCT05944900. IPD Sharing: Not stated. Countries: 1. Publications: 0.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov24/100

SAFETY AND EFFICACY OF ENDOSCOPIC CONVENTIONAL CYANOACRYLATE GLUE VS EUS-GUIDED COIL PLUS CYANOACRYLATE TECHNIQUE IN THE TREATMENT OF GASTRIC VARICES: A RANDOMIZED CONTROLLED TRIAL

ClinicalTrials.gov study NCT05038319. IPD Sharing: Not stated. Countries: 1. Publications: 0.

restrictedIPD-UNDECIDEDFeb 2026View details →

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International Brain Laboratory public data

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