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ShareScore release 0.9.0
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39 results for “Cytotrophoblast”
Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts
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Data from: Role of serotonin in human placental cytotrophoblast differentiation and gene expression
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Perfluorooctanoic acid induces transcriptomic alterations in 2nd trimester human cytotrophoblasts
<p>Poly- and perfluroroalkylated substances (PFAS) are a major class of surfactants used in industry applications and consumer products. Despite efforts to reduce the usage of PFAS due to their environmental persistence, compounds such as perfluorooctanoic acid (PFOA) are widely detected in human blood and tissue. While growing evidence supports that prenatal exposures to PFOA and other PFAS are linked to adverse pregnancy outcomes, the target organs and pathways remain unclear. Recent investigations in mouse and human cell lines suggest that PFAS may impact the placenta and impair trophoblast function. In this study, we investigated the effects of PFOA on cytotoxicity and the transcriptome in cultured 2nd-trimester human CTBs. We show that PFOA significantly reduces viability and induces cell death at 24h, in a concentration-dependent manner. At subcytotoxic concentrations, PFOA impacted expression of hundreds of genes, including several molecules (CRH, IFIT1, and TNFSF10) linked with lipid metabolism and innate immune response pathways. Furthermore, in silico analyses suggested that regulatory factors such as peroxisome proliferator-activated receptor (PPAR)-mediated pathways may be especially important in response to PFOA. In summary, this study provides evidence that PFOA alters primary human CTB viability and gene pathways that could contribute to placental dysfunction and disease.</p>
Perfluorooctanoic acid induces transcriptomic alterations in 2nd trimester human cytotrophoblasts
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RRBS investigation of matched side-population trophoblast, cytotrophoblast and extravillous trophoblast populations from 4 human placentae
GEO Series GSE109682. Homo sapiens. 12 samples. Type: Methylation profiling by high throughput sequencing.
Transcriptome analysis of cytotrophoblasts and syncytiotrophoblasts derived from trophoblast stem cells, mock-infected or infected with Toxoplasma gondii
GEO Series GSE263615. Toxoplasma gondii; Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Nuclear Matrix Association in Proliferative and Invasive Cytotrophoblasts
GEO Series GSE17501. Homo sapiens. 8 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array.
Trajectory modeling of first trimester placenta highlight differences between cytotrophoblast progenitors and trophoblast stem cells [scRNA-Seq 2]
GEO Series GSE298474. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Human cytotrophoblast organoids
GEO Series GSE109976. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Trajectory modeling of first trimester placenta highlight differences between cytotrophoblast progenitors and trophoblast stem cells
GEO Series GSE270174. Homo sapiens. 50 samples. Type: Expression profiling by high throughput sequencing; Other.
Primary mid-trimester and term human cytotrophoblast, untreated [RNA-Seq]
GEO Series GSE124282. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing of first trimester human cytotrophoblasts expressing a constitutively active mutant (5SA) of the transcriptional co-activator YAP.
GEO Series GSE143858. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing of syncytializing first trimester human cytotrophoblasts.
GEO Series GSE143860. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Placental Accreta Spectrum: Upregulated Cytotrophoblast DOCK4 Contributes to Over Invasion
GEO Series GSE136048. Homo sapiens. 9 samples. Type: Expression profiling by array.
Placental cytotrophoblast microvillar stabilization is required for cell-cell fusion
GEO Series GSE279087. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state
GEO Series GSE49354. Homo sapiens. 126 samples. Type: Expression profiling by array.
Culturing Cytotrophoblasts Reverses Gene Dysregulation in Preeclampsia Revealing Possible Causes
GEO Series GSE40182. Homo sapiens. 39 samples. Type: Expression profiling by array.
Trajectory modeling of first trimester placenta highlight differences between cytotrophoblast progenitors and trophoblast stem cells [scRNA-seq]
GEO Series GSE270170. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation profiling of first trimester villous cytotrophoblasts
GEO Series GSE93208. Homo sapiens. 19 samples. Type: Methylation profiling by array.
Trajectory modeling of first trimester placenta highlight differences between cytotrophoblast progenitors and trophoblast stem cells [Spatial Transcriptomics]
GEO Series GSE270173. Homo sapiens. 29 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.