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ShareScore release 0.9.0
Dataset results
11 results for “DNA repair mechanism”
Utilizing insights of DNA repair machinery to discover MMEJ deletions and novel mechanisms
<p><span>We developed Del-read, an algorithm targeting medium-sized deletions (6-100 bp) in short-reads, which are challenging for current variant callers relying on alignment. Our focus was on Micro-Homolog mediated End Joining deletions (MMEJ-dels), prevalent in myeloid malignancies. MMEJ-dels follow a distinct pattern, occurring between two homologies, allowing us to generate a comprehensive list of MMEJ-dels in the exome. Using Del-read, we identified numerous novel germline and somatic MMEJ-dels in BEAT- AML and TCGA-breast datasets. Validation in 672 healthy individuals confirmed their presence. These novel MMEJ-dels were linked to genomic features associated with replication stress, like G-quadruplexes and minisatellite. <a name="_Hlk170686758"></a>Additionally, we observed a new category of MMEJ-dels with an imperfect match at the flanking sequences of the homologies, suggesting a mechanism involving mispairing in homology alignment. We demonstrated robustness of the repair system despite CRISPR-Cas9-induced mismatches in the homologies. Further analysis of the canonical ASXL1 deletion revealed a diverse array of these imperfect matches. This suggests a potentially more flexible and error-prone MMEJ repair system than previously understood. Our findings highlight Del-read's potential in uncovering previously undetected deletions and deepen our understanding of repair mechanisms.</span></p>
Genomic Profiling of Diabetic Foot Ulcers Identifies miR-15b-5p as a Major Regulator that Leads to Suboptimal Inflammatory Response and Diminished DNA Repair Mechanisms
GEO Series GSE80178. Homo sapiens. 12 samples. Type: Expression profiling by array.
Mechanism of homology search expansion during recombinational DNA repair
GEO Series GSE272969. Saccharomyces cerevisiae. 67 samples. Type: Other.
Removal of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy.
GEO Series GSE227871. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
53BP1 integrates DNA repair and p53-dependent cell fate decisions via distinct mechanisms
GEO Series GSE84986. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
The Anticancer Mechanism of the Ribonucleotide Reductase Inhibiting Drug COH29 Involves Suppression of DNA Repair
GEO Series GSE55004. Homo sapiens. 8 samples. Type: Expression profiling by array.
Chemical inhibition of APE1 redox and DNA repair functions affects the inflammatory response via different but overlapping mechanisms.
GEO Series GSE182813. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Unraveling Resistance Mechanisms to the Novel Nucleoside Analog RX-3117 in lung cancer: Insights into DNA Repair, Cell Cycle Dysregulation and Targeting PKMYT1 for Improved Therapy
GEO Series GSE300920. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Elucidating cisplatin resistance mechanisms in squamous cervical cancer: Proteomic insights into intracellular DNA repair pathways while exploring the horizons of omics-driven drug repurposing
<p>The following dataset consists of mass spectrometry-based-DIA global proteomics data of HPV16+ cervical cancer cell lines.</p>
Mechanisms of DNA double strand break repair in Arabidopsis non-homologous end joining mutants
GEO Series GSE6178. Arabidopsis thaliana. 4 samples. Type: Expression profiling by array.
Unraveling a mechanism driving poor-prognosis prostate cancer: overexpression of the DNA repair gene, ribonucleotide reductase small subunit M2
GEO Series GSE118845. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.