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7 results for “DSLS”
Differential static light scattering (DSLS) of full-length huntingtin samples of different polyQ lengths (Q19, Q23, Q42 and Q54) – 2018/05/09
<p><strong>Project</strong> - Huntingtin structure-function open lab notebook. </p> <p><strong>Experiment</strong> - Differential static light scattering (DSLS) of full-length huntingtin samples of different polyQ lengths (Q19, Q23, Q42 and Q54) – 2018/05/09. To investigate how increased polyQ length of the huntingtin protein affects its biophysical properties. </p> <p> </p>
A time-course analysis using Differential Static Light Scattering (DSLS) of purified HTT1-3144 Q23 - 2019/01/28
<p><strong>Project: </strong>Biophysical investigation of purified HTT protein samples</p> <p><strong>Experiment: </strong>A time-course analysis using Differential Static Light Scattering (DSLS) of purified HTT<sup>1-3144</sup>Q23 </p> <p><strong>Date completed:­ </strong>2019/01/28</p> <p><strong>Rationale: </strong>Time and resources in the HD field have been primarily focussed on understanding HTT aggregation looking as caspase cleavage products spanning aa. 1-586 or exon 1 spanning aa. 1-90. However, we know that HTT protein purified in its apo form is able to self-associate into larger oligomeric species and that monomer, dimer and larger species are found following FLAG-affinity chromatography as determined by size-exclusion chromatography (SEC) and SEC-multi-angle light scattering (SEC-MALS). This experiment aimed to begin to investigate how HTT self-associates and aggregates over time in a range of different conditions. </p>
Investigating huntingtin-DNA binding by EMSA and DSLS (2017/05/31)
<p>Huntingtin structure-function open lab notebook project</p>
Multivocal Literature Mapping on DSLs and Tools for Entity-Relationship Modeling
<p><strong>[ERES 2021 - Fórum de Pós-Graduação]</strong></p> <p><strong>Abstract:</strong> The variety of database system technologies that became available in recent years makes difficult the selection of tools for modeling entity-relationship (ER). In this sense, we contribute with an overview of the recent innovations through a systematic literature mapping complemented by research in the gray literature. This paper scopes ten (10) primary studies focused on Domain-Specific Languages (DSL) and identifies fifty-five (55) tools already applied in industry and academia for ER modeling at the conceptual, logical, and physical level. Hence, as a significant increment to existing mapping studies, this presents the state of the art and practice for ER modeling, including its characterization and research gaps.</p>
Buffer screen by DSLS of C-HEAT and N-HEAT domains
<p>Raw data and summary of results of DSLS data recorded for C-HEAT_2088-3144 (TOC019 C01), and constructs of the N-HEAT domain: N-HEAT_76-404 (TOC019 B02), N-HEAT_93-404 (TOC019 A03), <a href="https://zenodo.org/record/3462496#.XY4U1mYpA2x">N-HEAT_81-1643 (TOC019 B08)</a>, N-HEAT_76-1715 (TOC019 A08).</p>
Replication Package for GECO: A Generator Composition Approach for Aspect-Oriented DSLs
<p>This replication package contains all information and sources used in<br> the evaluation of the GECO research project. For resources on github,<br> we provide the necessary github URL and, if available, Eclipse update<br> sites. For software based on git repositories, we also provide the<br> revision id of the used software, as other revisions might produce other<br> results.</p> <p> </p> <p><strong>Software Setup</strong></p> <p>Eclipse Mars</p> <ul> <li>Xtext 2.9 and tooling including Xtend</li> <li>Kieler Release 2016-02 http://www.rtsys.informatik.uni-kiel.de/en/research/kieler/</li> </ul> <p>Architecture Evaluation Tooling</p> <ul> <li>github repository https://github.com/rju/architecture-evaluation-tool</li> <li>Eclipse update site https://build.se.informatik.uni-kiel.de/eus/se/snapshot/</li> </ul> <p>Additional software relevant to setup the case studies are listed in<br> their respective README files.</p> <p> </p> <p><strong>Directory Structure</strong></p> <ul> <li>menges/ all sources and data for the embedded control system case study based on the MENGES project</li> <li>cocome/ all sources and data for the information system case study based on CoCoME</li> </ul>
Differential static light scattering (DSLS) of huntingtin-HAP40 complex samples of different polyQ lengths (Q23 and Q54) – 2018/10/13
<p>Project - Huntingtin structure-function open lab notebook. </p> <p>Experiment - Differential static light scattering (DSLS) of huntingtin-HAP40 complex samples of different polyQ lengths (Q23 and Q54) - 2018/10/13. To investigate how increased polyQ length of the huntingtin protein and complex formation of HAP40 might affect thermal aggregation properties of the samples. </p>
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