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103 results for “DUX4”
DUX4 expression activates JNK and p38 MAP kinases in myoblasts: MAJIQ splicing results
<p>Facioscapulohumoral muscular dystrophy (FSHD) is caused by misexpression of the DUX4 transcription factor in skeletal muscle that results in transcriptional alterations, abnormal phenotypes, and cell death. To gain insight into the kinetics of DUX4-induced stresses, we activated DUX4 expression in myoblasts and performed longitudinal RNA sequencing (GEO GSE205421) paired with proteomics and phosphoproteomics (MassIVE MSV000089812). This analysis revealed changes in cellular physiology including DNA damage and altered mRNA splicing. Phosphoproteomic analysis uncovered widespread changes in protein phosphorylation rapidly following DUX4 induction indicating that alterations in kinase signaling may play a role in DUX4-mediated stress and cell death. Indeed, we demonstrate that two stress-responsive MAP kinase pathways, JNK and p38, are activated in response to DUX4 expression. Inhibition of each of these pathways ameliorated DUX4-mediated cell death in myoblasts. These findings uncover JNK as a novel pathway involved in DUX4-mediated cell death as well as provide additional insights into the role of the p38 pathway, a clinical target for the treatment of FSHD.</p>
DUX4 expression activates JNK and p38 MAP kinases in myoblasts: MAJIQ splicing results
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DUX4 activates germline genes, retroelements and immune-mediators: Implications for facioscapulohumeral dystrophy
GEO Series GSE33799. Homo sapiens. 36 samples. Type: Expression profiling by array.
Retroelements and DUX4 Create Primate-specific Promoters for Germline Genes
GEO Series GSE45883. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
CIC-DUX4 chromatin profiling reveals new epigenetic dependencies and actionable therpaeutic targets in CIC-rearranged sarcomas [RNA-seq]
GEO Series GSE248116. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Analysis of genes regulated by DUX4 via oxidative stress reveals potential therapeutic targets for treatment of facioscapulohumeral dystrophy
GEO Series GSE173762. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
DUX4 activates germline genes, retroelements and immune-mediators: Implications for facioscapulohumeral dystrophy
GEO Series GSE33838. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Conservation and innovation in the DUX4-family gene network [MMH6 ChIP-Seq]
GEO Series GSE93168. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
DUX4 orchestrates translational reprograming by broadly suppressing translation efficiency [polysome-seq]
GEO Series GSE206436. Homo sapiens. 24 samples. Type: Other.
Conserved roles for murine mDUX and human DUX4 in activating cleavage stage genes and MERVL/HERVL retrotransposons [RNA-Seq]
GEO Series GSE72379. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction
GEO Series GSE186244. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures
GEO Series GSE113133. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
WDR5 is required for DUX4 expression and its pathological effects in FSHD muscular dystrophy
GEO Series GSE210610. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression and cell death
GEO Series GSE130522. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression
GEO Series GSE178760. Homo sapiens. 12 samples. Type: Other.
DUX4 is a multifunctional factor priming human embryonic genome activation
GEO Series GSE171803. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Cellular transcriptome upon HSV-1 infection or DUX4 overexpression
GEO Series GSE101435. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
DUX4 induced by HSV-1 infection promotes viral replication
GEO Series GSE279339. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
DUX4-induced transcripts from pericentric human satellite II repeats form double-stranded RNA
GEO Series GSE114940. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes
GEO Series GSE78158. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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