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3 results for “Dantrolene Sodium”
A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome
ClinicalTrials.gov study NCT02829268. IPD Sharing: NO. Countries: 1. Publications: 2.
Green spectrofluorimetric assay of dantrolene sodium via reduction method: application to content uniformity testing
<p>The green analysis has turned out to be of a great value in all areas, including pharmaceutical analysis. Thus, it is extremely important to consider the environmental influence of each step in developing any analysis technique. The present work illustrates a validated, simple and green spectrofluorimetric method for the analysis of dantrolene sodium. The developed process is characterized by being of high sensitivity as well as being relatively inexpensive. The suggested technique based on the formation of a highly fluorescent product of dantrolene sodium via its reduction by the aid of Zn/HCl system. The resulting fluorophore showed a powerful fluorescence at λ<sub>em</sub> 344 nm after excitation at λ<sub>ex</sub> 279 nm. Calibration graph revealed a great linear regression (r = 0.9998) within concentration ranging from 0.05 to 2.0 µg mL<sup>−1</sup>. The suggested method had a very low detection and quantification limit of 0.007 ng mL<sup>−1</sup> and 0.019 ng mL<sup>−1</sup>, respectively. The applied technique was effectively used in the determination of dantrolene sodium in its pharmaceutical preparations. The results were compared with those from using the official USP method and they were in a good agreement. Moreover, content uniformity testing of dantrolene sodium in capsules was performed adopting the investigated technique with satisfying results. The greenness of the suggested technique was confirmed by the three standard assessment tools. Therefore, the developed technique can be used in the routine quality control analysis of dantrolene sodium with minimum harmful impact on nature or individuals.</p>
Green spectrofluorimetric assay of dantrolene sodium via reduction method: application to content uniformity testing
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