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488 results for “Deep Brain Stimulation”
Effects of ON/OFF deep brain stimulation on cognitive control in treatment-resistant depression (EEG)
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Human es-fMRI Resource: Concurrent deep-brain stimulation and whole-brain functional MRI
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Micro-CT images of deep brain stimulation leads
<p>The dataset contain micro-CT images of leads used in deep brain stimulation. A lead comprises multiple electrodes and enables the delivery of electrical pulses to the brain to treat medical conditions such as Parkinson's disease, essential tremor or epilepsy. Images were acquired with a Skyscan 1276 micro-CT system from Bruker. Each image is provided in Nifti format (.nii) along with its corresponding log file (.log) generated by the scanner. The file names indicate the manufacturer and sample model. 'BS' denotes Boston Scientific.<br><br>Images can be visualized at:<br>https://activgroup.github.io/DBS-lead-microCT/<br><br>To contribute, please contact thomas.billoud@uniklinik-freiburg.de</p>
Dataset related to article"Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience"
<p>Demographic, clinical (BFMDRS at baseline and in follow up), implantation (frame and frameless) data for the sample considered in the study.</p>
Follow Up Study for Treatment of Parkinson's Disease With Deep Brain Stimulation
ClinicalTrials.gov study NCT01022073. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Datasets related to the manuscript 'Hypothalamic deep brain stimulation augments walking after spinal cord injury'
<p>The deposited datasets consist in the following:<br>Supplementary Table 1: All kinematics data and statistical analyses</p> <p>Supplementary Table 2: All differential analyses and statistics for the quantification of transcriptional activity (cFos) and spinal cord-projecting neurons (Rabies) from the contralesional (right) lateral hypothalamus (n = 3 per group).</p> <p> </p>
Microelectrode register (MER) data from Deep Brain Stimulation (DBS) surgery in Parkinson's disease patients
<p>MER data consist of brain signal in different depths when DBS surgery is being done. In each depth, a data file is created, with different duration depending on the depth, and up to three channels.</p> <p>Data come from 14 patients (9 males and 5 females), they are anonymized and labelled from P1 to P14. They correspond to patients in age 65.1 +- 5.6 years.</p> <p>Data are organized in STN-IN and STN-OUT (different depths in each folder), subthalamus-in, and subthalamus-out since the STN area is the target area when implanting a DBS. Classification in STN-IN and STN-OUT was made by the neurophysiologists and surgeons.</p> <p>Data were recorded for left and right lobes, 8 patients in left and right lobe, 1 patient in right lobe, and 5 patients in left lobe.</p> <p>The format is mat file (MATLAB file)</p> <p>Data sampling frequency is 12kHz.</p> <p>No filtering or data processing was made, they are directly obtained from the MER acquisition system.</p> <p> </p>
Data for: Deep brain stimulation in early-stage Parkinson disease
<p><strong>Objective</strong>: To report 5-year outcomes from the subthalamic nucleus (STN) deep brain stimulation (DBS) in early-stage Parkinson disease (PD) pilot clinical trial.</p> <p><strong>Methods</strong>: The pilot was a prospective, single-blind clinical trial that randomized patients with early-stage PD (Hoehn & Yahr II off medications) to receive bilateral STN DBS plus optimal drug therapy (ODT) vs ODT alone (IDEG050016, NCT0282152, IRB040797). Participants who completed the 2-year trial participated in this observational follow-up study, which included annual outpatient visits through 5 years. This analysis includes 28 patients who were taking PD medications for 6 months to 4 years at enrollment. Outcomes were analyzed using both proportional odds logistic regression and linear mixed effects models.ResultsEarly STN DBS + ODT participants required lower levodopa equivalent daily doses (p = 0.04, β = −240 mg, 95% confidence interval [CI] −471 to −8) and had 0.06 times the odds of requiring polypharmacy at 5 years compared to early ODT participants (p = 0.01, odds ratio [OR] 0.06, 95% CI 0.00 to 0.65). The odds of having worse rest tremor for early STN DBS + ODT participants were 0.21 times those of early ODT participants (p < 0.001, OR 0.21, 95% CI 0.09 to 0.45). The safety profile was similar between groups.</p> <p><strong>Conclusions</strong>: These results suggest that early DBS reduces the need for and complexity of PD medications while providing long-term motor benefit over standard medical therapy. Further investigation is warranted, and the Food and Drug Administration has approved the conduct of a prospective, multicenter, pivotal clinical trial of DBS in early-stage PD (IDEG050016).</p> <p><strong>Classification of evidence</strong>: This study provides Class II evidence that DBS implanted in early-stage PD decreases the risk of disease progression and polypharmacy compared to optimal medical therapy alone.</p>
Physical Therapy and Deep Brain Stimulation in Parkinson Disease
ClinicalTrials.gov study NCT03181282. IPD Sharing: NO. Countries: 1. Publications: 1.
Tourette Syndrome Deep Brain Stimulation
ClinicalTrials.gov study NCT02056873. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation
ClinicalTrials.gov study NCT01200433. IPD Sharing: NO. Countries: 1. Publications: 1.
Deep Brain Stimulation for the Treatment of Traumatic Brain Injury
ClinicalTrials.gov study NCT02881151. IPD Sharing: NO. Countries: 1. Publications: 2.
Reclaim Deep Brain Stimulation Clinical Study for Treatment-Resistant Depression
ClinicalTrials.gov study NCT00837486. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Phase I Deep Brain Stimulation (DBS) vs. Best Medical Therapy (BMT) Trial
ClinicalTrials.gov study NCT00056563. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
ClinicalTrials.gov study NCT01839396. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Asymmetric Subthalamic Deep Brain Stimulation for Axial Motor Dysfunction in Parkinson's Disease
ClinicalTrials.gov study NCT03462082. IPD Sharing: YES. Countries: 1. Publications: 4.
Trial Comparing Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Parkinson's Disease
ClinicalTrials.gov study NCT02401308. IPD Sharing: NO. Countries: 1. Publications: 8.
Use of Two Deep Brain Stimulation (DBS) Electrodes to Treat Post-Traumatic Tremor
ClinicalTrials.gov study NCT00954421. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
ClinicalTrials.gov study NCT06669546. IPD Sharing: NO. Countries: 1. Publications: 4.
Effectiveness of Deep Brain Stimulation for Treating People With Treatment Resistant Obsessive-Compulsive Disorder
ClinicalTrials.gov study NCT00640133. IPD Sharing: Not stated. Countries: 1. Publications: 7.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.