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48 results for “Deoxycholate”
Data from: Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
<p><span>Deoxycholate (DA) is a natural emulsifying agent involved in the absorption of dietary lipids. Due to the facial distribution of hydrophobic-hydrophilic region, DA easily aggregates under ambient conditions, and this property hinders the practical application of DA in clinical application. In this study, we found that the molecular arrangement of DA molecules could be controlled by utilizing layered double hydroxide (LDH) under a specific reaction condition. The effect of reaction methods such as co-precipitation, ion exchange, and reconstruction on the molecular arrangement of DA was investigated by X-ray diffraction, Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy, and differential scanning calorimetry. It was demonstrated that the self-aggregation of DA molecules could be suppressed by the oriented arrangement of DA between the gallery space of LDH. The DA moiety was well stabilized in the LDH layers due to the electrostatic interaction between DA molecules and LDH layers. The most ordered arrangement of DA molecules was observed when DA was incorporated into LDH via a reconstruction method. The DA molecules arranged in LDH via reconstruction did not show significant exothermic nor endothermic behavior up to 400</span><span>℃</span><span>, showing that the DA moiety lost its intermolecular attraction in between LDH layers.</span></p>
Open-Label Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental Area
ClinicalTrials.gov study NCT01426373. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat
ClinicalTrials.gov study NCT01305577. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Patient Experience Study of Deoxycholic Acid Injection
ClinicalTrials.gov study NCT02007434. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase 1-2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat
ClinicalTrials.gov study NCT00618722. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Data from: Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
Open the record for dataset details and reuse information.
Safety, Tolerability, and Efficacy of Caspofungin Versus Amphotericin B Deoxycholate in the Treatment of Invasive Candidiasis in Neonates and Infants (MK-0991-064)
ClinicalTrials.gov study NCT01945281. IPD Sharing: YES. Countries: 0. Publications: 1.
Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area
ClinicalTrials.gov study NCT01546142. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat
ClinicalTrials.gov study NCT01294644. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Phase 2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat
ClinicalTrials.gov study NCT00618618. IPD Sharing: Not stated. Countries: 3. Publications: 0.
Safety Study of ATX-101 (Deoxycholic Acid) in Subjects With Mild or Extreme Fullness of Submental Fat
ClinicalTrials.gov study NCT02035267. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluating the Efficacy and Safety of Embella (Deoxycholic Acid, Produced by Espad Pharmed Co.) for the Treatment of Flank Fat
ClinicalTrials.gov study NCT07004010. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Efficacy of Deoxycholic Acid Injection for Reduction of Upper Inner Thigh Fat
ClinicalTrials.gov study NCT04054011. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal
ClinicalTrials.gov study NCT00851747. IPD Sharing: NO. Countries: 1. Publications: 0.
Effectiveness and Safety Evaluation of Embella (Deoxycholic Acid, by Espad Pharmed Co.) in Management of Submental Fat
ClinicalTrials.gov study NCT06509438. IPD Sharing: NO. Countries: 1. Publications: 0.
Deoxycholic Acid Injection Submental Fat (SMF) Magnetic Resonance Imaging (MRI) and Subject-reported Outcome Measures Study
ClinicalTrials.gov study NCT01032889. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area
ClinicalTrials.gov study NCT01542034. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Safety Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental Area in Subjects 65 to 75 Years of Age
ClinicalTrials.gov study NCT02123134. IPD Sharing: Not stated. Countries: 1. Publications: 0.
High-Fat Diet Driven Post-Operative Colon Cancer Recurrence is Dependent upon Genetic Susceptibility to Deoxycholic Acid [tRNA-seq]
GEO Series GSE288276. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
High-Fat Diet Driven Post-Operative Colon Cancer Recurrence is Dependent upon Genetic Susceptibility to Deoxycholic Acid
GEO Series GSE287424. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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