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ShareScore release 0.9.0
Dataset results
67 results for “Dermis”
Anterior Colporrhaphy Versus Cystocele Repair Using Polypropylene Mesh or Porcine Dermis
ClinicalTrials.gov study NCT01393171. IPD Sharing: NO. Countries: 1. Publications: 4.
Data from: Monocyte recruitment to the dermis and differentiation to dendritic cells increases the targets for Dengue virus replication
Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease in humans. Although Aedes mosquitoes transmit DENV when probing for blood in the skin, no information exists on DENV infection and immune response in the dermis, where the blood vessels are found. DENV suppresses the interferon response, replicates, and causes disease in humans but not wild-type mice. Here, we used mice lacking the interferon-α/β receptor (Ifnar–/–), which had normal cell populations in the skin and were susceptible to intradermal DENV infection, to investigate the dynamics of early DENV infection of immune cells in the skin. CD103+ classical dendritic cells (cDCs), Ly6C– CD11b+ cDCs, and macrophages in the steady-state dermis were initial targets of DENV infection 12-24 hours post-inoculation but then decreased in frequency. We demonstrated recruitment of adoptively-transferred Ly6Chigh monocytes from wild-type and Ifnar–/– origin to the DENV-infected dermis and differentiation to Ly6C+ CD11b+ monocyte-derived DCs (moDCs), which became DENV-infected after 48 hours, and were then the major targets for virus replication. Ly6Chigh monocytes that entered the DENV-infected dermis expressed chemokine receptor CCR2, likely mediating recruitment. Further, we show that ~100-fold more hematopoietic cells in the dermis were DENV-infected compared to Langerhans cells in the epidermis. Overall, these results identify the dermis as the main site of early DENV replication and show that DENV infection in the skin occurs in two waves: initial infection of resident cDCs and macrophages, followed by infection of monocytes and moDCs that are recruited to the dermis. Our study reveals a novel viral strategy of exploiting monocyte recruitment to increase the number of targets for infection at the site of invasion in the skin and highlights the skin as a potential site for therapeutic action or intradermal vaccination.
Label-free imaging of M1 and M2 macrophage phenotypes in the human dermis in vivo using two-photon excited FLIM
<p>Macrophages (ΜΦs) are important immune effector cells that promote (M1 ΜΦs) or inhibit (M2 ΜΦs) inflammation and are involved in numerous physiological and pathogenic immune responses. Their precise role and relevance, however, are not fully understood for lack of non-invasive quantification methods. Here, we show that two-photon excited fluorescence lifetime imaging (TPE-FLIM), a label-free non-invasive method, can visualize ΜΦs in the human dermis in vivo. We demonstrate in vitro that human dermal ΜΦs exhibit specific TPE-FLIM properties that distinguish them from the main components of the extracellular matrix and other dermal cells. We visualized ΜΦs, their phenotypes and phagocytosis in the skin of healthy individuals in vivo using TPE-FLIM. Additionally, machine learning identified M1 and M2 MФs with a sensitivity of 0.88±0.04 and 0.82±0.03 and a specificity of 0.89±0.03 and 0.90±0.03, respectively. In clinical research, TPE-FLIM can advance the understanding of the role of MФs in health and disease.</p>
Acellular Matrix From Human Dermis in Combination With Orthobiologic Stimuli for Augmentation of Massive Rotator Cuff Tears
ClinicalTrials.gov study NCT05855759. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effects of Capacitive Radiofrequency at the Dermis and Adipose Tissue
ClinicalTrials.gov study NCT04182542. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Label-free imaging of M1 and M2 macrophage phenotypes in the human dermis in vivo using two-photon excited FLIM
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Data from: Second harmonic generation imaging reveals entanglement of collagen fibers in the elephant trunk skin dermis
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Data from: Monocyte recruitment to the dermis and differentiation to dendritic cells increases the targets for Dengue virus replication
Open the record for dataset details and reuse information.
Study of Root Coverage With Acellular Dermal Matrix: Puros® Dermis Versus Alloderm®
ClinicalTrials.gov study NCT00881959. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Axis™ Allograft Dermis for Female Pelvic Floor Repair: a Prospective Post Market Study
ClinicalTrials.gov study NCT01541748. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prrx1 fibroblasts represent a pro-fibrotic lineage in the mouse ventral dermis
GEO Series GSE159345. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
total RNA-seq from dermis blood vessel endothelial cell (ENCSR000AAI)
GEO Series GSE78536. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomic profile of CD45+ and CD45- cells from dermis and hypodermis of C57BL/6 mice
GEO Series GSE228018. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
RNAseq profiling of back dermis from epidermal-specific SPRY1-deficient (Spry1 cKO) mice and control mice
GEO Series GSE289141. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Global transcriptional profiles of abdominal skin dermis during perinatal period
GEO Series GSE151212. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Adult mouse LN, dermis and epidermis Treg scRNAseq
GEO Series GSE175746. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
total RNA-seq from dermis lymphatic vessel endothelial cell (ENCSR000AAJ)
GEO Series GSE78537. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Microarray data of epidermis and dermis from virgin and pregnant mice
GEO Series GSE86158. Mus musculus. 10 samples. Type: Expression profiling by array.
A Dermis-on-a-Chip Model for Compound Screening
GEO Series GSE300701. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
total RNA-seq from fibroblast of dermis (ENCSR000CUH)
GEO Series GSE78610. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.