Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
15
datasets available to search
ShareScore release 0.9.0
Dataset results
15 results for “Dieldrin”
Data for: Developmental origins of Parkinson’s disease risk: perinatal exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain
Open the record for dataset details and reuse information.
Data from: Developmental Dieldrin exposure alters DNA methylation at genes related to dopaminergic neuron development and Parkinson's disease in mouse midbrain
Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Despite previous work showing a link between developmental dieldrin exposure and increased neuronal susceptibility to MPTP toxicity in male C57BL/6 mice, the mechanism mediating this effect has not been identified. Here, we tested the hypothesis that developmental exposure to dieldrin increases neuronal susceptibility via genome-wide changes in DNA methylation. Starting at 8 weeks of age and prior to mating, female C57BL/6 mice were exposed to 0.3 mg/kg dieldrin by feeding (every 3 days) throughout breeding, gestation, and lactation. At 12 weeks of age, pups were sacrificed and ventral mesencephalon, containing primarily substantia nigra, were microdissected. DNA was isolated and dieldrin-related changes in DNA methylation were assessed via reduced representation bisulfite sequencing (RRBS). We identified significant, sex-specific differentially methylated CpGs (DMCs) and regions (DMRs) by developmental dieldrin exposure (FDRNr4a2 and Lmx1b genes, which are involved in dopaminergic neuron development and maintenance. Developmental dieldrin exposure had distinct effects on the male and female epigenome. Together, our data suggest that developmental dieldrin exposure establishes sex-specific poised epigenetic states early in life. These poised epigenomes may mediate sensitivity to subsequent toxic stimuli and contribute to the development of late-life neurodegenerative disease, including PD.
Fitness costs associated with a GABA receptor mutation conferring dieldrin resistance in Aedes albopictus
<p><span>Understanding the dynamics of insecticide resistance genes in mosquito populations is pivotal for a sustainable use of insecticides. Dieldrin resistance in <em>Aedes</em> <em>albopictus</em> is conferred by the alanine to serine substitution (A302S or <em>Rdl<sup>R</sup></em> allele) in the γ-aminobutyric acid (GABA) receptor encoded by the <em>Rdl</em> gene. On Reunion Island, dieldrin resistance was initially reported in natural <em>Ae</em>. <em>albopictus</em> populations sampled in 2008 despite the ban of dieldrin since 1994. To monitor insecticide resistance in <em>Ae</em>. <em>albopictus</em> on the island and to identify its drivers, we measured (i) the frequency of resistance alleles in 19 distinct natural populations collected between 2016 and 2017, (ii) fitness costs associated with dieldrin resistance in laboratory-controlled experiments, and (iii) the resistance conferred by </span><span><em>Rdl<sup>R</sup></em></span><span> to fipronil, an insecticide widely used on the island and reported to cross-react with </span><span><em>Rdl<sup>R</sup></em></span><span>. The results show a persistence of </span><span><em>Rdl<sup>R</sup></em></span><span> in <em>Ae</em>. <em>albopictus</em> natural populations at low frequencies. Among the measured life history traits, mortality in pre-imaginal stages, adults' survival as well as the proportion of egg-laying females were significantly affected in resistant mosquitoes. Finally, bioassays revealed resistance of </span><span><em>Rdl<sup>R</sup></em></span><span> mosquitoes to fipronil, suggesting that the use of fipronil <em>in</em> <em>natura</em> could select for the </span><span><em>Rdl<sup>R</sup></em></span><span> allele. This study shows that dieldrin resistance is persistent in natural mosquito populations likely as a result of combined effects between fitness costs associated with </span><span><em>Rdl<sup>R</sup></em></span><span> and selection exerted by cross-reacting environmental insecticides such as fipronil.</span></p>
Data from: Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice
<p>Parkinson's disease (PD) is the fastest-growing neurological diseases worldwide, with increases outpacing aging and most rapid in recently industrialized areas, suggesting the role of environmental factors. Together, epidemiological studies, post-mortem analysis and mechanistic studies suggest that exposure to persistent organic pollutants, including the organochlorine pesticide dieldrin, increases PD risk. In mouse models, developmental dieldrin exposure causes male-specific exacerbation of neuronal susceptibility to MPTP and synucleinopathy. Specifically, developmental dieldrin exposure induces male-specific exacerbation of toxicity in the α-synuclein (α-syn) pre-formed fibril (PFF) model with increased deficits in striatal dopamine (DA) turnover and motor deficits on the challenging beam. Here, we hypothesized that alterations in DA handling contribute to the observed changes and assessed vesicular monoamine transporter 2 (VMAT2) function and DA release in this dieldrin/PFF two-hit model. Female C57BL/6 mice were exposed to 0.3 mg/kg dieldrin or vehicle every 3 days by feeding, starting at 8 weeks of age by ingestion and continuing throughout breeding, gestation, and lactation. Male offspring from independent litters underwent unilateral, intrastriatal injections of α-syn PFFs at 12 weeks of age and vesicular <sup>3</sup>H-DA uptake assays and fast-scan cyclic voltammetry (FSCV) were performed at 4 months post-PFF injection. We observed a dieldrin-induced increase in DA release in striatal slices in PFF-injected animals, but no change in VMAT2 activity. These results suggest that developmental dieldrin exposure increases a compensatory response to synucleinopathy-triggered striatal DA loss and supports our hypothesis that alterations in DA handling may underly the observed exacerbation of PFF-induced deficits in motor behavior and DA turnover.</p>
Fitness costs associated with a GABA receptor mutation conferring dieldrin resistance in Aedes albopictus
Open the record for dataset details and reuse information.
Data from: Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice
Open the record for dataset details and reuse information.
Developmental dieldrin exposure alters DNA methylation at genes related to dopaminergic neuron development and Parkinson’s disease in mouse midbrain
Open the record for dataset details and reuse information.
Impact of dieldrin on transcription in Jurkat T cells
GEO Series GSE111167. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
The genomic effects of dieldrin in the hypothalamus of largemouth bass
GEO Series GSE16402. Micropterus salmoides. 8 samples. Type: Expression profiling by array.
Acute Dieldrin Exposure on Global Gene Transcription in Largemouth bass (Micropterus salmoides) Hypothalamus
GEO Series GSE12698. Micropterus salmoides. 8 samples. Type: Expression profiling by array.
Developmental Dieldrin Exposure Alters DNA Methylation at Genes Related to Dopaminergic Neuron Development and Parkinson’s Disease in Mouse Midbrain
GEO Series GSE134636. Mus musculus. 58 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Dieldrin augments mTOR signaling and inhibits lysosomal acidification in the adult zebrafish heart (Danio rerio)
GEO Series GSE87294. Danio rerio. 15 samples. Type: Expression profiling by array.
Molecular Characterization of Dieldrin in the Zebrafish (Danio rerio) Hypothalamus
GEO Series GSE71638. Danio rerio. 16 samples. Type: Expression profiling by array.
Developmental origins of Parkinson’s disease risk: developmental exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in th
GEO Series GSE264165. Mus musculus. 150 samples. Type: Methylation profiling by high throughput sequencing.
Sexually dimorphic transcriptomic responses in the largemouth bass to the neuroactive pesticide dieldrin
GEO Series GSE27963. Micropterus salmoides. 20 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.