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7 results for “Diffuse low-grade glioma”
Data from: Post-operative follow-up for selected diffuse low-grade gliomas with WHO grade III/IV foci
Objective: Diffuse low-grade gliomas (DLGG) are defined by a continuous growth and an almost unavoidable malignant transformation. Foci of malignant glioma can be found within DLGG samples obtained from surgical resections. As the medical management of patients is classically based on the higher tumor grade, an immediate adjuvant treatment is usually proposed. To determine whether postponing the medical treatment in selected patients is feasible, we conducted a single-center retrospective study. Methods: Single-center retrospective analysis of a consecutive series of DLGG managed with this conservative strategy. Inclusion criteria were: at least one focus of malignant tumor (grade III-IV, WHO 2016), no previous chemotherapy or radiotherapy, no less than a subtotal resection of the FLAIR tumor volume, no intention of treating with immediate adjuvant therapy, minimum two years of follow-up. The time interval to the following oncological medical treatment was analyzed, as well as the functional and survival results. Results: 45 patients met the inclusion criteria (median age 36.5, median time interval from diagnosis: 7.3 months). Most tumors (86.7%) were IDH-mutant and 1p19q intact (60.0%); 10 presented with grade IV foci. With a median follow-up of 6.3 years, 75.5% of patients received a subsequent medical treatment, after a median time of 3.7 years since surgery. At the time of analysis, 9 patients (20.0%) had died (5-years and 7-years survival rates: 95.2% and 67.0%). Most surviving patients were still active professionally, without seizures. Conclusions: Postponing the medical treatment in DLGG with foci of malignant tumor following total or subtotal resection should be considered in selected patients.
Data from: Post-operative follow-up for selected diffuse low-grade gliomas with WHO grade III/IV foci
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Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent, oncogenic MYBL1-truncating rearrangements
GEO Series GSE45843. Homo sapiens. 44 samples. Type: Genome variation profiling by array; Genome variation profiling by genome tiling array.
Longitudinal MRI Assessment in Patients With Diffuse Low-grade Gliomas
ClinicalTrials.gov study NCT04346472. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Foci of Tumor Heterogeneity in Diffuse Low-Grade Gliomas
ClinicalTrials.gov study NCT04423094. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Evaluation of Cognitive and Motor Neurological Disorders in the Short and Long Term After Surgery for the Removal of a Diffuse Low-grade Glioma of the Supplementary Motor Area
ClinicalTrials.gov study NCT05373394. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
High density foci in IDH1-mutated diffuse low-grade gliomas in adults
GEO Series GSE130149. Homo sapiens. 16 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.