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86 results for “Dopamine Receptors”
Dataset: Insular cortex dopamine 1 and 2 receptors in methamphetamine conditioned place preference and aversion: Age and sex differences
<p>Dataset for Insular cortex dopamine 1 and 2 receptors in methamphetamine conditioned place preference and aversion: Age and sex differences</p>
Data for: Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster
<p>Fertility is a major component of fitness but its genetic architecture remains poorly understood. Using a full diallel cross of 50 <em>Drosophila</em> <em>melanogaster</em> Genetic Reference Panel inbred lines with whole genome sequences, we found substantial genetic variation in fertility largely attributable to females. We mapped genes associated with variation in female fertility by genome-wide association analysis of common variants in the fly genome. Validation of candidate genes by RNAi knockdown confirmed the role of the dopamine 2-like receptor (<em>Dop2R</em>) in promoting egg laying. We replicated the <em>Dop2R</em> effect in an independently collected productivity dataset and showed that the effect of the <em>Dop2R</em> variant was mediated in part by regulatory gene expression variation. This study demonstrates the strong potential of genome-wide association analysis in this diverse panel of inbred strains and subsequent functional analyses for understanding the genetic architecture of fitness traits.</p>
Data for: Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster
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Data from: Oxytocin and dopamine receptor expression: Cellular level implications for pair bonding
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Dopamine Receptor Agonist Therapy for Pain Relief in Women Suffering From Endometriosis: A Pilot Study
ClinicalTrials.gov study NCT02542410. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate Sigma-1 and Dopamine-2 Receptor Occupancy by Pridopidine in the Human Brain of Healthy Volunteers and in Patients With Huntington's Disease
ClinicalTrials.gov study NCT03019289. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Citalopram Effects on Craving and Dopamine Receptor Availability in Alcoholics
ClinicalTrials.gov study NCT01657760. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Safety and Tolerability of the D1 Dopamine Receptor Antagonist Ecopipam in Patients With Lesch-Nyhan Disease
ClinicalTrials.gov study NCT01065558. IPD Sharing: Not stated. Countries: 1. Publications: 1.
D1 and D2 Dopamine Receptors in Gambling and Amphetamine Reinforcement
ClinicalTrials.gov study NCT02203786. IPD Sharing: NO. Countries: 1. Publications: 7.
Data from: Dopamine and serotonin co-transmission filters striatonigral synaptic activity via 5-HT1B receptor activation
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Post-processed data for: Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns
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Data from: Genetic polymorphism in dopamine receptor D4 is associated with early body condition in a large population of greater flamingos, Phoenicopterus roseus
Body condition is an important determinant of fitness in many natural populations. However, as for many fitness traits, the underlying genes that regulate body condition remain elusive. The dopamine receptor D4 gene (DRD4) is a promising candidate as dopamine is known to play an important role in the regulation of food intake and the metabolism of both glucose and lipids in vertebrates. In this study we take advantage of a large dataset of greater flamingos, Phoenicopterus roseus, to test whether DRD4 polymorphism predicts early body condition (EBC) while controlling for whole genome effects of inbreeding and outbreeding using microsatellite multi-locus heterozygosity (MLH). We typed 670 of these individuals for exon 3 of the homologue of the human DRD4 gene and 10 microsatellite markers. When controlling for effects of yearly environmental variations and differences between sexes, we found strong evidence of an association between exon 3 DRD4 polymorphisms and EBC, with 2.2-2.3% of the variation being explained by DRD4 polymorphism, whereas there was only weak evidence that MLH predicts EBC. Because EBC is most likely a polygenic trait, this is a considerable amount of variation explained by a single gene. This is to our knowledge the first study to show an association between exon 3 DRD4 polymorphism and body condition in nonhuman animals. We anticipate that the DRD4 gene as well as other genes coding for neurotransmitters and their receptors may play an important role in explaining variation in traits that affect fitness.
Fig. 4 in Corybungines A K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity
Fig. 4. (A) Experimental and calculated ECD spectra of compound 1 in MeOH. (B) Experimental ECD spectra of compounds 6–11 in MeOH.
Fig. 5 in Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC
Fig. 5. Dose-dependent curve of compound 1 inhibiting the RFU signals of dopamine on HEK293-D1 cells.
Study of Dopamine Transporter Receptor Occupancy With Long-acting Dex-methylphenidate
ClinicalTrials.gov study NCT00593138. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dopamine and Opioid Receptor Antagonists Reduce Cue-induced Reward Responding and Reward Impulsivity
ClinicalTrials.gov study NCT02557984. IPD Sharing: Not stated. Countries: 1. Publications: 9.
24-Hour Time Course of Striatal Dopamine D2 Receptor Occupancy of Ziprasidone: A PET Study
ClinicalTrials.gov study NCT00818298. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Positron Emission Tomography Imaging of Dopamine Receptors Using the Tracer [11C]NNC-112
ClinicalTrials.gov study NCT00088517. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Dopamine Receptor Imaging in Mood Disorders
ClinicalTrials.gov study NCT00116077. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI
ClinicalTrials.gov study NCT02148783. IPD Sharing: Not stated. Countries: 1. Publications: 2.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.