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7 results for “Drosophila C virus”
Drosophila serrata mutation accumulation lines: Phenotypic data on survival following infection with Drosophila C virus and reproduction
<p>The impact of selection on host immune function genes has been widely documented. However, it remains essentially unknown how mutation influences the quantitative immune traits that selection acts on. Applying a classical mutation accumulation (MA) experimental design in <em>Drosophila serrata</em>, we found the mutational variation in susceptibility (median time of death, LT50) to Drosophila C virus (DCV) was of similar magnitude to that reported for intrinsic survival traits. Mean LT50 did not change as mutations accumulated, suggesting no directional bias in mutational effects. Maintenance of genetic variance in immune function is hypothesised to be influenced by pleiotropic effects on immunity and other traits that contribute to fitness. To investigate this, we assayed female reproductive output for a subset of MA lines with relatively long or short survival times under DCV infection. Longer survival time tended to be associated with lower reproductive output, suggesting that mutations affecting susceptibility to DCV had pleiotropic effects on investment in reproductive fitness. Further studies are needed to uncover the general patterns of mutational effect on immune responses and other fitness traits, and to determine how selection might typically act on new mutations via their direct and pleiotropic effects.</p>
Drosophila serrata mutation accumulation lines: Phenotypic data on survival following infection with Drosophila C virus and reproduction
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Data from: Costs and benefits of sub-lethal Drosophila C virus infection
Viruses are major evolutionary drivers of insect immune systems. Much of our knowledge of insect immune responses derives from experimental infections using the fruit fly Drosophila melanogaster. Most experiments, however, employ lethal pathogen doses through septic injury, frequently overwhelming host physiology. While this approach has revealed several immune mechanisms, it is less informative about the fitness costs hosts may experience during infection in the wild. Using both systemic and oral infection routes we find that even apparently benign, sub-lethal infections with the horizontally transmitted Drosophila C Virus (DCV) can cause significant physiological and behavioral morbidity that is relevant for host fitness. We describe DCV-induced effects on fly reproductive output, digestive health, and locomotor activity, and we find that viral morbidity varies according to the concentration of pathogen inoculum, host genetic background and sex. Notably, sub-lethal DCV infection resulted in a significant increase in fly reproduction, but this effect depended on host genotype. We discuss the relevance of sub-lethal morbidity for Drosophila ecology and evolution, and more broadly, we remark on the implications of deleterious and beneficial infections for the evolution of insect immunity.
Data and code for "The restriction factor pastrel is associated with host vigor, viral titer, and variation in disease tolerance during Drosophila C Virus infection"
<p>Raw data and R code for:</p> <p>Kutzer M, Gupta V, Neophytou K, Doublet V, Monteith KM, Vale PF. The restriction factor pastrel is associated with host vigor, viral titer, and variation in disease tolerance during Drosophila C Virus infection. bioRxiv. 2022; 2022.06.09.495537. doi:<a href="https://doi.org/10.1101/2022.06.09.495537">10.1101/2022.06.09.495537</a></p> <p>Data files are:</p> <p>titre.csv. -viral titre for 10 DGRP lines, males and females, 6 doses of DCV, measured 3 days post-infection<br> survival.csv -survival for 10 DGRP lines, males and females, 6 doses of DCV.<br> fecundity.csv - number of offspring produced by females of 10 DGRP lines when infected with 6 doses of DCV.<br> expression_MK. Baseline and infected expression of G9a and Upd3 for 10 DGRP lines, males and females, following exposure to 10e7 DCV IU/ml.</p>
Data from: Costs and benefits of sub-lethal Drosophila C virus infection
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Analysis of IKKb (Ird5) regulated genes in control and hemizygote IKKb (Ird5) null mutant adult flies after DCV (Drosophila C virus) infection
GEO Series GSE99043. Drosophila melanogaster. 8 samples. Type: Expression profiling by array.
Transcriptional response of Drosophila S2 cells in response the Drosophila C Virus infection (DCV)
GEO Series GSE57434. Drosophila melanogaster. 6 samples. Type: Expression profiling by array.
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