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11
datasets available to search
ShareScore release 0.9.0
Dataset results
11 results for “Drug Matrix”
National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT02664935. IPD Sharing: NO. Countries: 1. Publications: 2.
Dataset used in "Deamidation analysis of Therapeutic Drugs using Matrix-assisted Laser Desorption Ionization Mass Spectrometry and A Novel Algorithm QuanDA"
<p><span>Overview</span></p> <p><span>Theoretical MALDI spectra of peptides, both before and after deamidation, are crucial for the analysis of real samples. QuanDA is a method utilizing non-negative least squares to calculate the percentage of deamidation during the aging process of standard peptides and therapeutic drugs.</span></p> <p><span>Dataset Description</span></p> <p><span>The `data` directory contains example datasets specifically designed for analyzing peptide deamidation:</span></p> <p><span>D.txt: Simulated spectra of the pure synthetic peptide Pep-D.</span></p> <p><span>N.txt: Simulated spectra of the pure synthetic peptide Pep-N.</span></p> <p><span>Asn2Asp18: Contains 10 measurements from a sample comprising 10% Pep-N and 90% Pep-D.</span></p> <p><span>Asn18Asp2: Comprises 10 measurements from a sample with 90% Pep-N and 10% Pep-D.</span></p> <p><span>Peptide Sequences: Pep-N: YTHQGLSSPVTKSFNRGE; Pep-D: YTHQGLSSPVTKSFDRGE</span></p> <p><span>These synthetic peptides are utilized to investigate deamidation behavior.</span></p> <p><span>Somatostatin Dataset: Contains data from actual samples analyzed over 0-13 days under physiological conditions (pH 7.4, 37°C) and storage conditions (pH 4, 4°C). This dataset includes theoretical values before and after deamidation.</span></p>
ToxicoDB: an integrated database to mine and visualize large-scale toxicogenomic datasets (drug matrix dataset)
<p>This data was generated by Ganter B, Snyder RD, Halbert DN, Lee MD. Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix database. Pharmacogenomics [Internet]. 2006 Oct;7(7):1025–1044. Available from: http://dx.doi.org/10.2217/14622416.7.7.1025 PMID: 17054413. The data have been curated and analyzed using our open-source R package, <em>ToxicoGx</em> (<a href="https://cran.r-project.org/web/packages/ToxicoGx/">cran.r-project.org/web/packages/ToxicoGx</a>) and are available publicly in the <em>ToxicoDB </em>web application (<a href="http://www.toxicodb.ca">www.toxicodb.ca</a>).</p> <p> </p> <p> </p>
Matrix Metalloproteinases Expression in the Neointimal Hyperplasia Induced by Drug Eluting Stent (DES) Implantation
ClinicalTrials.gov study NCT03375528. IPD Sharing: YES. Countries: 0. Publications: 2.
Dormancy-inducing 3D engineered matrix uncovers mechanosensitive and drug-protective FHL2-p21 signaling axis
GEO Series GSE182606. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Cymbopogon Citratus Gel as Local Drug Delivery Agent in Reducing Matrix Metalloproteinase-8 Levels Intra-crevicularly in the Treatment of Stage II Periodontitis
ClinicalTrials.gov study NCT05241509. IPD Sharing: YES. Countries: 1. Publications: 0.
Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial
ClinicalTrials.gov study NCT05947500. IPD Sharing: YES. Countries: 2. Publications: 0.
Drug Matrix Data - Affymetrix Arrays
GEO Series GSE57822. Rattus norvegicus. 5587 samples. Type: Expression profiling by array.
Drug Matrix Data - CodeLink Arrays
GEO Series GSE59927. Rattus norvegicus. 12921 samples. Type: Expression profiling by array.
Augmented Drug Resistance of Osteosarcoma Cells within Decalcified Bone Matrix Scaffold: the role of Glutamine Metabolism
GEO Series GSE234632. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Enhancing Tumor Targeting of Antitumor Drugs through Anlotinib-Mediated Modulation of Extracellular Matrix and RhoA/ROCK Signaling Pathway
GEO Series GSE237818. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.