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ShareScore release 0.9.0
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12 results for “Dynamine”
Dynamin-dependent entry of Chlamydia trachomatis is sequentially regulated by the effectors TarP and TmeA
<p><em>Chlamydia</em> invasion of epithelial cells is a pathogen-driven process involving two functionally distinct effectors – TarP and TmeA. They collaborate to promote robust actin dynamics at sites of entry. Here, we extend studies on the molecular mechanism of invasion by implicating the host GTPase dynamin 2 (Dyn2) in the completion of pathogen uptake. Importantly, Dyn2 function is modulated by TarP and TmeA at the levels of recruitment and activation through oligomerization, respectively. TarP-dependent recruitment requires phosphatidylinositol 3-kinase and the small GTPase Rac1, while TmeA has a post-recruitment role related to Dyn2 oligomerization. This is based on the rescue of invasion duration and efficiency in the absence of TmeA by the Dyn2 oligomer-stabilizing small molecule activator Ryngo 1-23. Notably, Dyn2 also regulated the turnover of TarP- and TmeA-associated actin networks, with disrupted Dyn2 function resulting in aberrant turnover dynamics, thus establishing the interdependent functional relationship between Dyn2 and the effectors TarP and TmeA.</p>
Dynamin-dependent entry of Chlamydia trachomatis is sequentially regulated by the effectors TarP and TmeA
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Early Phase Human Drug Trial to Investigate Dynamin 101 (DYN101) in Patients ≥ 16 Years With Centronuclear Myopathies
ClinicalTrials.gov study NCT04033159. IPD Sharing: NO. Countries: 6. Publications: 0.
Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics
GEO Series GSE162983. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice
GEO Series GSE156982. Mus musculus. 2 samples. Type: Expression profiling by array.
Effects of Dynamine Ingestion on Various Indices of Sustained Energy
ClinicalTrials.gov study NCT06048640. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The Effects of a Combination of TeaCrine®, Dynamine, and Caffeine in Law Enforcement
ClinicalTrials.gov study NCT03937687. IPD Sharing: NO. Countries: 1. Publications: 0.
Dynamin-like proteins are essential for vesicle biogenesis in Mycobacterium tuberculosis.
GEO Series GSE143996. Mycobacterium tuberculosis H37Rv. 7 samples. Type: Expression profiling by high throughput sequencing.
Depletion of oocyte dynamin-related protein 1 shows maternal effect abnormalities in embryonic development
GEO Series GSE180579. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Interaction of solute carrier family 39 member 1 and dynamin related protein 1 to facilitate development of hepatocellular carcinoma by impairing mitochondrial quality control
GEO Series GSE268875. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Altered cell signaling in the absence of Dynamin function: a transcriptomic approach from yeast to humans (yeast)
GEO Series GSE78267. Saccharomyces cerevisiae; Schizosaccharomyces pombe. 6 samples. Type: Expression profiling by array.
Altered cell signaling in the absence of Dynamin function: a transcriptomic approach from yeast to humans (human)
GEO Series GSE78269. Homo sapiens. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.