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283 results for “Dystonia”
Dataset related to article"Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience"
<p>Demographic, clinical (BFMDRS at baseline and in follow up), implantation (frame and frameless) data for the sample considered in the study.</p>
Raw data for: "Vesicular Acetylcholine Transporter Alters Cholinergic Tone and Synaptic Plasticity in DYT1 Dystonia"
<p>Raw data for Supplemental Figure 2 - Patch-Clamp recordings of ChI firing activity after bath application of donepezil (Donep 50 μM, 5 minutes). The inhibition by donepezil was weaker in Tor1a+/− than in Tor1a+/+ neurons.</p>
Home-based measurements of dystonia and choreoathetosis in cerebral palsy using smartphone-coupled inertial sensor technology and machine learning: A proof-of-concept study - dataset
<p>Home-based measurements of dystonia in cerebral palsy using smartphone-coupled inertial sensor technology and machine learning: A proof-of-concept study</p> <p> </p> <p>This project contains:</p> <p>- 1 main MATLAB script: MODYSathome_main.m<br> - 12 MATLAB functions:<br> - function_calc_mean_recall_precision.m<br> - function_create_dataframes.m<br> - function_deep_learning.m<br> - function_determine_best_ML_model.m<br> - function_display_DL_results.m<br> - function_display_ML_results.m<br> - function_index_extremities.m<br> - function_machine_learning.m<br> - function_oversample.m<br> - function_partition_data.m<br> - function_pick_best_models.m<br> - function_prepare_DL_data.m</p> <p>Downloading the Matlab scripts</p> <p> - Create a folder named 'MODYS' and create a subfolder named 'results'<br> - Download the zip file via <a href="https://zenodo.org/record/6379348">RehabAUmc/modys-at-home: v1.0 | Zenodo</a><br> - Unzip the zip file in the path MODYS\</p> <p>STEPS<br> 1. Open MATLAB<br> 2. In MATLAB, go to the 'HOME' tab and click on 'Set Path'<br> 3. Click on 'Add Folder' and browse to MODYS/RehabAUmc-modys-at-home-86b14c3/functions<br> 4. Click on 'Select Folder' and click on 'Save'<br> 5. Click on 'Browse to folder' and browse to a patients' data in MODYS/data/PatientXXX, then click on 'Select Folder'<br> 6. In the 'HOME' tab click on 'Open' and open MODYSathome.m in MODYS/RehabAUmc-modys-at-home-86b14c3<br> 7. In the 'EDITOR' tab click on 'Run Section' to run the script<br> 8. When the code has been run, the results are displayed in the Command Window and saved in MODYS/results/PatientXXX</p>
Replication Data For: Spiking patterns in the globus pallidus highlight convergent neural dynamics across diverse genetic dystonia syndromes
<div><strong>Human Globus Pallidum Single-Unit Activity Dataset in Genetic Dystonia Patients</strong></div> <div> </div> <div>This dataset consists of tabular data encompassing diverse neural features extracted from spiking trains of stable single-unit activity. These units were isolated from raw microelectrode recordings obtained from the globus pallidum of genetic dystonia patients who underwent globus pallidus internal (GPi) deep brain stimulation (DBS) surgery. The dataset includes anonymized patient IDs, details about the patient's genetic dystonia mutation, as well as information on the hemisphere and depth of microelectrode recordings (MER). Additionally, it features neural properties such as firing rate, spiking regularity, neural bursts, oscillations, and pause characteristics of isolated single-unit activities (SUAs).</div> <div> </div> <div>To process the raw MER, we applied a semi-parametric offline spike sorting algorithm to isolate SUAs. The SUAs were analyzed both in the temporal and frequency domains to derive a comprehensive set of features related to spiking patterns.</div> <div> </div> <div>For those interested in replicating or understanding the feature extraction process, the MATLAB source code is available in the <a href="github.com/ahmetofficial/Spike-Feature-Generator">Github repository</a>.</div>
Study Comparing Short Term Efficacy of Dysport and Dysport NG to Placebo, and to Assess Efficacy and Safety of Dysport NG of Subjects With Cervical Dystonia
ClinicalTrials.gov study NCT01261611. IPD Sharing: YES. Countries: 11. Publications: 1.
Randomized, Placebo-Controlled Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia
ClinicalTrials.gov study NCT00257660. IPD Sharing: YES. Countries: 2. Publications: 2.
dataset relared to article "Childhood‑onset dystonia‑causing KMT2B variants result in a distinctive genomic hypermethylation profile"
<p>Sanger sequences (.abi files) of all patients of Fondazione Besta cohort.</p>
Dataset related toa article: "Dystonia as a prominent feature of TCF20-associated neurodevelopmental disorder: Expanding the phenotype"
<p>Sanger sequences (.abi files) validating variants found with whole exome sequencing</p>
Datset related to article: "ACTB gene mutation in combined Dystonia-Deafness syndrome with parkinsonism: Expanding the phenotype and highlighting the long-term GPi DBS outcome"
<p>Sanger sequences (.abi files) validating variants found with whole exome sequencing</p>
Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex
ClinicalTrials.gov study NCT01486264. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia
ClinicalTrials.gov study NCT01753336. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia
ClinicalTrials.gov study NCT00447772. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia.
ClinicalTrials.gov study NCT01753310. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias
ClinicalTrials.gov study NCT01373424. IPD Sharing: YES. Countries: 7. Publications: 1.
rTMS and Retraining in Focal Hand Dystonia
ClinicalTrials.gov study NCT01738581. IPD Sharing: NO. Countries: 1. Publications: 3.
Open-label Extension Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia
ClinicalTrials.gov study NCT00288509. IPD Sharing: YES. Countries: 2. Publications: 2.
Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand
ClinicalTrials.gov study NCT02107261. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Effects of Neuromodulation in Laryngeal Dystonia
ClinicalTrials.gov study NCT05095740. IPD Sharing: YES. Countries: 1. Publications: 16.
Deep Brain Stimulation in Patients With Dystonia
ClinicalTrials.gov study NCT00773604. IPD Sharing: YES. Countries: 1. Publications: 1.
Amlodipine Plus Botulinum Toxin for Focal Dystonia
ClinicalTrials.gov study NCT00015457. IPD Sharing: Not stated. Countries: 1. Publications: 3.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.