Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
9
datasets available to search
ShareScore release 0.9.0
Dataset results
9 results for “E-proteins”
Interleukin-6 (IL-6) activates the NOTCH1 signaling pathway through E-proteins in endometriotic lesions
<p><b>Context:</b> NOTCH signaling is activated in endometriotic lesions but the exact mechanisms remains unclear. Interleukin-6 (IL-6), which is increased in the peritoneal fluid of women with endometriosis, induces NOTCH1 through E-proteins including E2A and HEB in cancer development.</p> <p><b>Objective:</b> To study the role of E-proteins in inducing NOTCH1 expression under the regulation of IL-6 in endometriosis.</p> <p><b>Setting and Design:</b> The expression of E2A, HEB and NOTCH1 was first investigated in endometrium of women with endometriosis and the baboon model of endometriosis. Regulation of E-proteins and NOTCH1 expression was examined after IL-6 stimulation and siRNA mediated inhibition of E2A or/and HEB in human endometriotic epithelial cells (12Z) <i>in vitro</i>, and subsequent following <i>in vivo </i>IL-6 treatment in the mouse model of endometriosis <i>in vivo</i>.</p> <p><b>Results: </b>E2A, HEB and NOTCH1 were significantly upregulated in glandular epithelium (GE) of ectopic endometrium compared to eutopic endometrium in both women and baboon model. IL-6 treatment upregulated the expression of NOTCH1 together with E2A and HEB in 12Z cells. siRNA inhibition of E2A and HEB or HEB alone decreased NOTCH1 expression. Binding efficiency of both E2A and HEB was significantly higher at the binding sites on the human NOTCH1 promoter after IL-6 treatment. Finally, IL-6 treatment resulted in a significantly increased number of endometriotic lesions along with the increased expression of E2A, HEB and NOTCH1 in GE of the lesions compared with the vehicle treated group in an endometriosis mouse model.</p> <p><span><b>Conclusions:</b> IL-6 induced NOTCH1 expression is mediated by E-proteins in the ectopic GE cells, which may promote endometriotic lesion development. </span></p>
Interleukin-6 (IL-6) activates the NOTCH1 signaling pathway through E-proteins in endometriotic lesions
Open the record for dataset details and reuse information.
A Prevalent Disease-Associated SNP in the Human ID3 Gene Regulates E-Protein Activity and Cellular Proliferation [HEK293T RNA-Seq]
GEO Series GSE316070. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Dynamic Changes in E-protein Activity are Essential for Treg cell Development
GEO Series GSE51654. Mus musculus. 8 samples. Type: Expression profiling by array.
The E-protein Daughterless regulates protein translation and memory in adult Drosophila nervous system [RNA-seq]
GEO Series GSE279158. Drosophila melanogaster. 8 samples. Type: Expression profiling by high throughput sequencing.
A Prevalent Disease-Associated SNP in the Human ID3 Gene Regulates E-Protein Activity and Cellular Proliferation [VMSC RNA-Seq]
GEO Series GSE316072. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Expression data from rhabdomyosarcoma cells expressing Myod and E-protein heterodimer and controls
GEO Series GSE14825. Homo sapiens. 6 samples. Type: Expression profiling by array.
The E-protein Daughterless regulates protein translation and memory in adult Drosophila nervous system
GEO Series GSE279107. Drosophila melanogaster. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
E-protein inhibition in ILC2 development shapes the function of mature ILC2s during allergic airway inflammation
GEO Series GSE185950. Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.