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1,472 results for “EGFR”
Data of FigS7, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS7, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS7.PNG). The Corresponding raw data and subsequent data analysis obtained contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M .txt) and one file as csv-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1.csv).</p>
Bevacizumab plus erlotinib versus erlotinib alone as first line treatment of patients with EGFR-mutated advanced nonsquamous non-small cell lung cancer. BEVacizumab plus ERLotinib studY (BEVERLY): an academic, multicenter, randomised phase III trial.
<p>Background. Adding bevacizumab to erlotinib prolonged PFS of patients with EGFR-mutated advanced NSCLC in the Japanese NEJ026 trial, but limited data were available in non-Asian patients. BEVERLY is an Italian, multicenter, randomized phase III trial of bevacizumab plus erlotinib versus erlotinib alone as first-line treatment of advanced EGFR-mutated NSCLC.</p> <p>Methods. Eligible patients were randomized 1:1 to erlotinib (150mg daily) plus bevacizumab (15mg/kg iv q3w) or erlotinib alone, until disease progression or unacceptable toxicity. Center, ECOG PS and type of mutation (ex19 deletion vs ex21 L858R vs others) were stratification variables. Investigator-assessed PFS (IA-PFS) and blinded-independent centrally-reviewed PFS (BICR-PFS) were co-primary endpoints. With 80% power in detecting a 0·60 HR and 2–sided α error 0·05, 126 events out of 160 patients were needed. The trial was registered as NCT02633189 and EudraCT 2015-002235-17.</p> <p>Findings. From Apr 11, 2016 to Feb 27, 2019, 160 pts were randomized to erlotinib pus bevacizumab (80) or erlotinib alone (80). Baseline characteristics were balanced between arms; 34 (42·5%) patients in erlotinib plus bevacizumab arm and 43 (53·8%) in erlotinib arm were former or current smokers. At a median follow-up of 36·3 months, 140 PFS events (87·5%) were reported, 68 with erlotinib plus bevacizumab and 72 with erlotinib. Median IA-PFS was 15·4 months (95% CI 12·2–18·6) with erlotinib plus bevacizumab and 9·6 months (95% CI 8·2–10·6) with erlotinib (HR 0·66; 95%CI: 0·47–0·92). BICR-PFS analysis confirmed this result. A significant interaction with treatment effect was found for smoking habit (P=0·0323): former or current smokers receiving erlotinib plus bevacizumab had a longer PFS (16·9 months [95% CI 10·2–21·8] versus 8·8 months [95% CI 5·6–9·6]) than those receiving erlotinib alone.</p> <p>Hypertension (grade≥3: 24% vs 5%), skin rash (grade≥3: 31% vs 14%), thromboembolic events (any grade: 11% vs 4%), and proteinuria (any grade: 23% vs 6%) were more frequent with the combination treatment.</p> <p>Interpretation. The addition of bevacizumab to first-line erlotinib significantly prolonged PFS in Italian patients with EGFR-mutated NSCLC, without unexpected safety issues.</p>
Data of FigS2, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS2, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS2.PNG). The corresponding raw data and subsequent data analysis obtained from proteomics analysis are provided as nine files in CSV format (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1-3_M1-3.csv). All further experiment related information provided as one meta-data-file (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1_M .txt) in txt format.</p>
Data of FigS4, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS4, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS4.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_6_M1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_6_M.txt) and three files in CSV-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_6_1-3.csv).</p>
Data of Fig7, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig7, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig7.PNG). The Corresponding raw data and subsequent data analysis obtained for TCGA analysis contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M.txt), and all further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M1.pdf)</p> <p> </p>
Data of Fig8, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig8, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig8.PNG). The Corresponding raw data and subsequent data analysis obtained for immunohistochemistry contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1_M .txt) and one file in csv-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1.csv), and all further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1_M1 .pdf)</p> <p> </p>
Data of Fig4, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig4, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig4.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_3_M_1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_3_M.txt). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as one files in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_4_M.txt), all further experiment related information provided as one meta-data-file in pdf format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_4_M_1.pdf).</p>
Data of Fig2, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig2, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig2.PNG). The corresponding raw data and subsequent data analysis obtained from proteomics analysis are provided as three files in CSV format (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1-3.csv). All further experiment related information provided as one meta-data-file (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1_M .txt) in txt format. Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_1_M_1 .pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_1_M.txt). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as one files in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_2_M.txt), all further experiment related information provided as one meta-data-file in pdf format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_2_M_1.pdf).</p>
Data of Fig5, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig5, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig5.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_4_M_1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_4_M.txt) and three files in CSV-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_4_3.csv). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as one files in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_5_M .txt) and three files in CSV format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_5-1-3.csv), all further experiment related information provided as three meta-data-files in pdf format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_5_M_1-3.pdf).</p>
Data of Fig6, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig6, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig6.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_5_M1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_5_M.txt) and three files in CSV-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_5_1-3.csv).</p> <p> </p>
Data of Fig3, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig3, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig3.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_2_M_1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_2_M.txt). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as one files in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_3_M.txt), all further experiment related information provided as one meta-data-file in pdf format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_3_M_1.pdf).</p>
Data of Fig1, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig1, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (doi: 10.3390/cancers14133074) contains the original figures as PNG-format (10.3390-cancers14133074_Fig1.PNG). Raw data and related Meta data are provides as one file in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_1_M.txt) and one file in PDF-Format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_1_M_1.pdf).</p>
Data of Fig9, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig9, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig9.PNG). The Corresponding raw data and subsequent data analysis obtained for immunohistochemistry contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1_M.pdf) and one file in csv-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1.csv), and all further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M .txt)</p> <p> </p>
Data of FigS3, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS3, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS3.PNG). The Corresponding raw data and subsequent data analysis obtained for TCGA analysis contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_3_M .txt), six files in csv-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_3-1-6 .csv) and one file in sps-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_3-4 .sps). All further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_2_M 1.pdf).</p>
Data of FigS5, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS5, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS5.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_7_M1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_7_M.txt).</p> <p> </p>
Data of FigS6, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS6, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS6.PNG). The Corresponding raw data and subsequent data analysis obtained for TCGA analysis contains two files in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1-2_M.txt). All further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M1.pdf).</p> <p> </p>
A Safety and Efficacy Study of INC280 and Gefitinib in Patients With EGFR Mutated, c-MET-amplified NSCLC Who Have Progressed After EGFRi Treatment
ClinicalTrials.gov study NCT01610336. IPD Sharing: YES. Countries: 14. Publications: 1.
HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT04619004. IPD Sharing: YES. Countries: 16. Publications: 2.
DS-1205c With Gefitinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT03599518. IPD Sharing: YES. Countries: 1. Publications: 1.
DS-1205c With Osimertinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT03255083. IPD Sharing: YES. Countries: 1. Publications: 2.
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