Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
7
datasets available to search
ShareScore release 0.9.0
Dataset results
7 results for “ER-stress response”
Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma engages the ER-stress response I
GEO Series GSE98785. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Artesunate shows potent anti-tumor activity in B-cell lymphoma by inducing ER-stress response
GEO Series GSE94553. Homo sapiens. 24 samples. Type: Expression profiling by array.
Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma engages the ER-stress response II
GEO Series GSE98786. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in in the Alzheimer’s mouse brain and retina
GEO Series GSE254524. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma engages the ER-stress response
GEO Series GSE98787. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profiling of the DTT induced ER-stress response in Plasmodium falciparum
GEO Series GSE52713. Plasmodium falciparum. 4 samples. Type: Expression profiling by array.
Dataset related to article "Identification of a class of non-conventional ER-stress response-derived immunogenic peptides (ERStreP)"
<p>This record contains raw data and scripts (R software) applied to get Figure 5 and Figure S8 related to article “Identification of a class of non-conventional ER-stress response-derived immunogenic peptides (ERStreP)”</p> <p>Immune checkpoint blockade (ICB) has changed the prognosis of previously untreatable tumors. However, a fraction of patients is refractory to ICB therapy. Ongoing efforts to overcome resistance have focused on vaccination strategies using neoepitopes, although these cannot be applied on a large scale due to the "private" nature of cancer mutations. Here we show that infection of tumor cells with <em>Salmonella</em> induces the opening of membrane hemichannels and the release of proteasome-generated peptides in the extracellular milieu via the exacerbation of endoplasmic reticulum (ER)-stress and the unfolded protein response. Peptides released by cancer cells induced a strong antitumor response <em>in vivo</em>, both in mice bearing B16F10 melanomas and in dogs suffering of osteosarcoma and high-grade sarcoma. Mass spectrometry analysis on the supernatant of human melanoma cells revealed 12 released peptides capable of priming healthy donor CD8<sup>+</sup> T cells that recognize and kill human melanoma cells <em>in vitro</em> and when xenotransplanted <em>in vivo</em>, but not healthy melanocytes. Hence, we identified a novel class of tumor antigens that are generated in ER-stressed cells, such as tumor cells, and that do not induce central or peripheral tolerance, nor are presented by healthy cells.</p> <p> </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.