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755 results for “EZH2”
Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy
<p>Supplementary data for Kazansky et al, "Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy" and "Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas." Raw RNA-seq data from G401 cells can be found at the Gene Expression Omnibus (GEO) repository, accession number GSE213845. RNA-seq data from patient tumor samples has been deposited to the Database of Genotypes and Phenotypes (dbGaP), accession number phs003188.v1.p1.</p> <p>All files are labeled with their corresponding figures.</p> <p>"DESeq_processing_FINAL.R" was used for analysis of patient RNA-seq data, using "20230131_SampleTable.csv" and all "*_htseq.txt" files as input.</p> <p>"Tumor_growth_analysis_FINAL_UPDATED" was used for analysis of tumor growth kinetics using the aucVardiTest function. This was used for both of the manuscripts desscribed above.</p>
Study of Tazemetostat in Participants With Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma With EZH2 Gene Mutation
ClinicalTrials.gov study NCT03456726. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of the EZH2 Inhibitor Tazemetostat in Malignant Mesothelioma
ClinicalTrials.gov study NCT02860286. IPD Sharing: NO. Countries: 3. Publications: 1.
Microarray analysis of EZH2 knockout HaCat cell lines
Open the record for dataset details and reuse information.
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia
ClinicalTrials.gov study NCT04215822. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Tre
ClinicalTrials.gov study NCT03213665. IPD Sharing: Not stated. Countries: 2. Publications: 0.
EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma
ClinicalTrials.gov study NCT02601937. IPD Sharing: Not stated. Countries: 9. Publications: 0.
Regulation of Angiogenesis by EZH2
GEO Series GSE20381. Homo sapiens. 12 samples. Type: Expression profiling by array.
Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency [LAM-HTGTS for MEC-1 cell]
GEO Series GSE310346. Homo sapiens. 37 samples. Type: Other.
Single-Cell RNAsequencing of Human Naïve Pluripotent Stem Cells to Trophoblast Stem Cells with and without EZH2 inhibition.
GEO Series GSE176173. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice [ChIP-seq]
GEO Series GSE262919. Mus musculus. 36 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Increased translation driven by a non-canonical EZH2 cistrome creates a synthetic vulnerability in enzalutamide-resistant prostate cancer (RNA-Seq LNCaP)
GEO Series GSE266950. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia
GEO Series GSE50951. Mus musculus. 4 samples. Type: Expression profiling by array.
Epigenetic profiling of prostate adenocarcinoma and neuroendocrine prostate cancer models to understand DNMT-EZH2 crosstalk. [RNA-Seq]
GEO Series GSE286958. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
microRNA-101 represses EZH2 in cancer
GEO Series GSE13674. Homo sapiens. 12 samples. Type: Expression profiling by array.
DNMT and EZH2 inhibitors synergize for gene activation in hepatocellular carcinoma cells [methylation array]
GEO Series GSE202559. Homo sapiens. 24 samples. Type: Methylation profiling by genome tiling array.
Implication of EZH2 in the hyper-proliferative and apoptosis-resistant phenotype of pulmonary artery smooth muscle cells in PAH: a transcriptomic and proteomic approach
GEO Series GSE166996. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer [expression]
GEO Series GSE41651. Homo sapiens. 6 samples. Type: Expression profiling by array.
Destabilization of B2 RNA by EZH2 activates the stress response
GEO Series GSE82255. Mus musculus. 61 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing.
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
GEO Series GSE100695. Homo sapiens; Mus. 52 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.