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Data_Supplemental_Tab3_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Data of supplemental Tab3, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice” The Dataset contains the original supplemental table 3 as PDF-format (PNTD-D-21-00134R2_S_T3.pdf). Related information (meta-data) are provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_ST3_M_1.txt) and three files in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_ST3_M_1-3.pdf).

Data_Supplemental_Fig4_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Data of supplemental Fig4, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice” The Dataset contains the original supplemental figure 4 as PNG-format (PNTD-D-21-00134R2_SFig4.png). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as four files in CSV format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF4_1_3-4_1-4.csv), all further experiment related information provided as one meta-data-file in txt format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF4_1_3-4_M_1.txt) and three meta data files in pdf format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF4_M_1-3.pdf).

Data_Supplemental_Fig2_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Data of supplemental Fig2, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice” The Dataset contains the original supplemental figure 2 as PNG-format (PNTD-D-21-00134R2_SFig2.png), original supp. table S1 (31003A-179400_PNTD-D-21-00134R2_FJ_MW_SS_Echinococcus_F1_M_3.pdf) and the original supplemental file S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_5.pdf). Corresponding raw data, subsequent data analysis and all further experiment related information (meta-data) from Western Blot analysis provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF2_2_1-26_M_1.txt) and two files in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF2_M_2-3.pdf).

Data_Supplemental_Fig3_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Data of supplemental Fig3, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice” The Dataset contains the original supplemental figure 3 as PNG-format (PNTD-D-21-00134R2_SFig3.png). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as two files in CSV format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_1_1-2_1-2.csv), all further experiment related information provided as one meta-data-file in txt format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_1_1-2_M_1.txt) and seven meta data files in pdf format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_1_1-2_M_2-4.pdf and 31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_M_1-3.pdf).

Data_Supplemental_Fig1_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Data of supplemental Fig1, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”   The Dataset contains the original supplemental figure 1 as PNG-format (PNTD-D-21-00134R2_SFig1.png). Related information (meta-data) are provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF1_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF1_M_2.pdf).

Data_Figure4_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Data of Fig4, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice” The Dataset contains the original figure 4 as PNG-format (PNTD-D-21-00134R2_Fig4.png). Related information (meta-data) are provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_Fig4_M_1.txt).

Data_Figure3_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Data of Fig3, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice” The Dataset contains the original figure 3 as PNG-format (PNTD-D-21-00134R2_Fig3.png), original supp. table S1 (31003A-179400_PNTD-D-21-00134R2_FJ_MW_SS_Echinococcus_F1_M_3.pdf) and raw blots as the original supplemental file S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_4.pdf). Corresponding raw data, subsequent data analysis and all further experiment related information (meta-data) from Western Blot analysis provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F3_2_13-14_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F3_M_2.pdf).

Data_Figure2_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Data of Fig2, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice” The Dataset contains the original figure 2 as PNG-format (PNTD-D-21-00134R2_Fig2.png). Corresponding raw data and subsequent data analysis obtained from Multiplex Luminex Cytokine measurement analysis provided as one files in CSV format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F2_22_1-2_1.csv). All further experiment related information (meta-data) provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F2_22_1-2_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F2_M_2.pdf).

opencc-by-4.0Jan 2022View details →

Data_Figure1_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice

Data of Fig1, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”   The Dataset contains the original figure 1 as PNG-format (PNTD-D-21-00134R2_Fig1.png), original supp. table S1 (31003A-179400_PNTD-D-21-00134R2_FJ_MW_SS_Echinococcus_F1_M_3.pdf), original supp. Figure S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_4.pdf) and the original supplemental file S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_5.pdf). Corresponding raw data, subsequent data analysis and all further experiment related information (meta-data) from Western Blot analysis provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_2_1-26_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_2.pdf).

opencc-zeroMar 2022View details →

Presence of Echinococcus multilocularis and Taenia taeniaformis in muskrats (Ondatra zibethicus)

This dataset describes the presence of Echinococcus multilocularis and Taenia taeniaformis in muskrats (Ondatra zibethicus) in Flanders, Belgium. From 1994 onward, muskrats from Flanders have been autopsied with the aim of understanding their demography. In 2008, we first detected EM in a muskrat from Lessines (Wallonia), just across the border with Flanders. Therefore, from 2009 onward, all available muskrats from Flanders and neighbouring regions were collected and examined. The dataset contains the following variables: <ul> <li><code>date</code>: YYYY-MM-DD</li> <li><code>province</code>: Flemish province where the muskrat was captured, for locations outside of Flanders only a municipality is provided</li> <li><code>municipality</code>: the municipality where the muskrat was captured</li> <li><code>weight</code>: the weight of the animal in grams</li> <li><code>sex</code>: either M: male or F: female</li> <li><code>taen</code>: Infection with Taenia taeniaformis, scored as: <ul> <li>0: No T. taeniaformis present</li> <li>1: Few T. taeniaformis present</li> <li>2: Multiple T. taeniaformis present</li> <li>3: A high number of T. taeniaformis present</li> </ul> </li> <li><code>EM</code>: Infection with Echinococcus multilocularis, scored as: <ul> <li>N: negative, no parasites present</li> <li>P: positive, parasite present</li> <li>?: unsure</li> </ul> </li> </ul>

Fig. 1 in Echinococcus multilocularis (Cestoda, Cyclophyllidea, Taeniidae): origin, differentiation and functional ultrastructure of the oncospheral tegument and hook region membrane

Fig. 1 Schematic diagram illustrating the origin (a) and beginning of differentiation (b) of the oncospheral tegument and hook region membrane in the preoncospheral stage of embryonic development of Echinococcus multilocularis. All structures involved in formation of the oncospheral tegument and hook region membrane are marked in orange colour. Two red arrows show direction of progressive sinking or migration of the binucleate subtegumental perikaryon which sunk deep into the central region of differentiating oncosphere. HFC hook-forming cell or oncoblast, HP hook primordium, HRC hook region cavity, IE inner envelope, m mitochondria, N1, N2 two nuclei of the binucleate complex primordium, N nucleus of hook-forming cell, PBC binucleate complex primordium, V vesicles in the outer cytoplasm, undergoing progressive fusion

Fig. 6 in Echinococcus multilocularis (Cestoda, Cyclophyllidea, Taeniidae): origin, differentiation and functional ultrastructure of the oncospheral tegument and hook region membrane

Fig. 6 TEM micrographs of mature eggs of Echinococcus multilocularis. a Part of the oncosphere showing the high concentration of beta-glycogen particles (β-gl) in the musculature of oncospheral hooks (HM) as indicated by the cytochemical test of Thiéry. b Low-power electron micrograph illustrating the general topography of mature intrauterine egg. Note: (1) a bilateral symmetry of the oncosphere (white interrupted line) and (2) position of hook region membrane and oncospheral tegument at one pole of the hexacanth. The hook region is marked by a frame composed of interrupted black lines. EmB embryophoric blocks, GC germinative cells, GL granular layer, HRM hook region membrane, IE inner envelope, LH lateral hooks, MH median hooks, OE outer envelope, OM oncospheral membrane, PG penetration glands, SC somatic cells

Fig. 5 in Echinococcus multilocularis (Cestoda, Cyclophyllidea, Taeniidae): origin, differentiation and functional ultrastructure of the oncospheral tegument and hook region membrane

Fig. 5 High-power TEM micrographs showing ultrastructural details of the oncospheral tegument and hook region membrane. a Note two oblique sections of blades of the oncospheral hooks (HBl), surrounded by numerous long microvilli (Mv) which protrude into large cavity situated under the hook region membrane (HRM) and oncospheral membrane (OM). b Oblique section through the hook region membrane showing hook blade exit and oncospheral tegument with numerous long microvilli at its surface. DR desmosome rings, HM hook musculature, IE inner envelope

Fig. 4 in Echinococcus multilocularis (Cestoda, Cyclophyllidea, Taeniidae): origin, differentiation and functional ultrastructure of the oncospheral tegument and hook region membrane

Fig. 4 Consecutive stages of a tegumental perikaryon migration. a Part of an embryo in the early preoncospheral stage of development showing much infolded oncospheral membrane and the binucleate perikaryon (BSP) of the oncospheral tegument in the early stage of its migration, sunken already below the peripheral layers of oncospheral musculature. b Part of the late stage of preoncospheral differentiation showing the binucleate perikaryon of oncospheral tegument sunk deep into the central part of the embryo and surrounded by differentiating blastomeres. H oncospheral hooks, HCF hook forming cell, HRM hook region membrane, IE inner envelope, N1, N2, nucleus, OE outer envelope, OM oncospheral membrane, SC somatic cells

Fig. 3 in Echinococcus multilocularis (Cestoda, Cyclophyllidea, Taeniidae): origin, differentiation and functional ultrastructure of the oncospheral tegument and hook region membrane

Fig. 3 Comparison of an early and advanced preoncospheral stage of embryonic development in Echinococcus multilocularis. a Ultrastructure of an embryo in the early preoncospheral stage of embryonic development. Note the binucleate complex primordium (PBC), which appears as a syncytial cap or "calotte" situated beneath the inner envelope (IE) at one pole of the developing embryo; two thick arrows mark the direction of progressive migration of both nuclei (N1, N2) surrounded by a thin layer of common cytoplasm and become transformed into the binucleate subtegumental perikaryon. b Part of the embryo in the advanced stage of preoncosphere showing the binucleate subtegumental perikaryon (BSP) of the tegumental syncytium sunk deep into the central part of the embryo and surrounded by differentiating blastomeres. Bl blastomere, C vitelline capsule, EmB embryophoric blocks, GL granular layer, H oncospheral hooks, HM hook muscles, HRM hook region membrane, KI keratin-like protein islands, MeN mesomere nucleus, OE outer envelope, OM oncospheral membrane, PG penetration gland, UW uterine wall

Fig. 2 in Echinococcus multilocularis (Cestoda, Cyclophyllidea, Taeniidae): origin, differentiation and functional ultrastructure of the oncospheral tegument and hook region membrane

Fig. 2 Schematic diagram illustrating the general topography of the oncospheral tegument and hook region membrane in relation to the oncospheral hooks, penetration gland arms and glandular exits in the mature intrauterine eggs. All structures involved in formation of the oncospheral tegument and hook region membrane are marked in orange colour. BSP binucleate subtegumental perikaryon, HRM hook region membrane, IE inner envelope LH lateral hooks, MH median hooks, Mv microvilli, N1, N2 nucleus, OT oncospheral tegument, PGA penetration glands arms

opencc-by-4.0Aug 2014View details →

Fig. 1 in Unexpected diversity of the cestode Echinococcus multilocularis in wildlife in Canada

Fig. 1. Map of Canada showing sites with samples positive for Echinococcus multilocularis in the current study. Carnivore icons (circles) in the Northwest Territories and rodent icons (squares) in southern Saskatchewan represent centrum data, not exact sampling locations. Boxed lettering represents haplotypes from this study. Provincial and territory abbreviations are as follows: Yukon territory (YT), Northwest territories (NT), Nunavut (NU), British Columbia (BC), Alberta (AB), Saskatchewan (SK), and Manitoba (MB).

opencc-by-4.0Aug 2014View details →

Fig. 2 in Unexpected diversity of the cestode Echinococcus multilocularis in wildlife in Canada

Fig. 2. Haplotype network of Echinococcus multilocularis. Network shows the relationships of haplotypes A–Q from a 370 base pair region of the nad1 mitochondrial gene, described in the current study from wild carnivores (Arctic fox, wolf, and coyote) and deer mice (dm) in western Canada, and previously published sequences (M1, M2 and a European-type strain recently isolated from a dog in BC). Network is based on statistical parsimony. Small, unlabelled circles indicate hypothetical haplotypes separated by a single nucleotide change from adjacent sequences. Labelled ovals and rectangles represent distinct haplotypes. Abbreviations for Canadian provinces and territories as for Fig. 1.

opencc-by-4.0Apr 2016View details →

Fig. 2 in First identification of Echinococcus multilocularis in rodent intermediate hosts in Sweden

Fig. 2. Macroscopic photos of rodent livers containing Echinococcus multilocularis metacestode lesions. The ruler in each picture is in millimeters. (A) Liver from Microtus agrestis with one lesion that contained protoscoleces. (B) Liver from Arvicola amphibius with multiple lesions that did not contain protoscoleces. (C) Liver from Arvicola amphibius with multiple lesions that did contain protoscoleces. (D) Liver from Arvicola amphibius. Arrow points to the only lesion examined for protoscoleces, which were absent.