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70 results for “Efferocytosis”
Modulation of Steroid Immunosuppression by Alveolar Efferocytosis
ClinicalTrials.gov study NCT03034642. IPD Sharing: NO. Countries: 1. Publications: 20.
Data from: Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis
Macrophages and neutrophils are the first responders to invading pathogens and contribute strongly to the host defense against intracellular pathogens. The collective interplay and dynamic interactions between these leukocytes are to a large extent not understood. In the present study, we have investigated their role using a combination of confocal laser-scanning and electron microscopy in a zebrafish model for tuberculosis, a local Mycobacterium marinum infection in the tissue of the larval tail fin. Our results show that neutrophils are efficient in phagocytosis of mycobacteria and that they contribute largely to their dissemination. Macrophages appear to play a major role in efferocytosis, phagocytosis of dead cells that contain bacterial content. Phagocytic cells with large bacterial aggregates are formed that can be extruded out of the tissue after cell death. Alternatively, these excessively infected cells can undergo necrosis leading to immediate recruitment of surrounding leukocytes and subsequent phagocytosis of released bacteria. Our data show that these necrotic burst events result in progression of the infection, whereas extrusion abates the infection.
Data from: Efferocytosis perpetuates substance accumulation inside macrophage populations
In both cells and animals, cannibalism can transfer harmful substances from the consumed to the consumer. Macrophages are immune cells that consume their own dead via a process called cannibalistic efferocytosis. Macrophages that contain harmful substances are found at sites of chronic inflammation, yet the role of cannibalism in this context remains unexplored. Here we take mathematical and experimental approaches to study the relationship between cannibalistic efferocytosis and substance accumulation in macrophages. Through mathematical modelling, we deduce that substances which transfer between individuals through cannibalism will concentrate inside the population via a coalescence process. This prediction was confirmed for macrophage populations inside a closed system. We used image analysis of whole slide photomicrographs to measure both latex microbead and neutral lipid accumulation inside murine bone marrow-derived macrophages (104-105 cells) following their stimulation into an inflammatory state ex vivo. While the total number of phagocytosed beads remained constant, cell death reduced cell numbers and efferocytosis concentrated the beads among the surviving macrophages. % from small to large numbers per cell. Since lipids are also conserved during efferocytosis, these cells accumulated lipid derived from the membranes of dead and consumed macrophages (becoming macrophage foam cells). Consequently, enhanced macrophage cell death increased the rate and extent foam cell formation. Our results demonstrate that cannibalistic efferocytosis perpetuates exogenous (e.g. beads) and endogenous (e.g. lipids) substance accumulation inside macrophage populations. As such, cannibalism has similar detrimental consequences in both cells and animals.
Mechanisms of Ozone-Induced Alterations in Efferocytosis and Phagocytosis
ClinicalTrials.gov study NCT03646877. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis
Open the record for dataset details and reuse information.
Data from: Efferocytosis perpetuates substance accumulation inside macrophage populations
Open the record for dataset details and reuse information.
Trem2 Macrophage Promote Cardiac Repair in Myocardial Infarction via Efferocytosis and Carbohydrate Metabolism
GEO Series GSE218002. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
High-throughput screen reveals that atypical antipsychotics promote continual efferocytosis by antagonizing dopamine signaling and promoting vitamin A-dependent Arginase 1 upregulation
GEO Series GSE286555. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Erroneous efferocytosis of live neutrophils during infection prevents the resolution of inflammation [RNAseq_dual_species]
GEO Series GSE264523. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Efferocytosis-induced metabolic shift in bone macrophages drives lactate production and modulates inflammation and osteoclastogenesis
GEO Series GSE300915. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Suppression of Notch during efferocytosis prevents macrophages inflammatory polarization [RNA-seq.Mouse]
GEO Series GSE283548. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Efferocytosis fuels malignant pleural effusion through TIMP1
GEO Series GSE172455. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide pooled CRISPR knockout screen for novel regulators of macrophage efferocytosis.
GEO Series GSE212008. Mus musculus. 15 samples. Type: Other.
Early Age Efferocytosis Directs Macrophage Arachidonic Acid Metabolism for Tissue Regeneration
GEO Series GSE241928. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Macrophage-produced VEGFC is induced by efferocytosis to resolve inflammation and improve ventricular function after myocardial infarction
GEO Series GSE196867. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Suppression of Notch during efferocytosis prevents macrophages inflammatory polarization [SLAM-seq]
GEO Series GSE283549. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
Stress granule assembly impairs macrophage efferocytosis [SG RNA-seq]
GEO Series GSE263848. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Broad-spectrum antibiotics disrupt homeostatic efferocytosis [scRNA-seq]
GEO Series GSE270512. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
RNA N-glycosylation enables innate immune evasion and homeostatic efferocytosis
GEO Series GSE291767. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Suppression of Notch during efferocytosis prevents macrophages inflammatory polarization [RNA-seq.HumanMouse]
GEO Series GSE283547. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.