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ShareScore release 0.9.0
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6 results for “Endocannabinoid signalling”
Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors
<p>The endocannabinoid (eCB) system, <i>via</i> cannabinoid CB<sub>1</sub> receptor, regulates neurodevelopment by controlling neural progenitor proliferation and neurogenesis. CB<sub>1</sub> receptor signalling <i>in vivo</i> drives corticofugal deep layer projection neuron development through the regulation of <span>BCL11B </span>and <span>Satb2</span> transcription factors. Here, we investigated the role of eCB signalling in mouse pluripotent embryonic stem cell-derived neuronal differentiation. Characterization of the eCB system revealed increased expression of eCB-metabolizing enzymes, eCB ligands and CB<sub>1</sub> receptors along neuronal differentiation. CB<sub>1</sub> receptor knockdown inhibited neuronal differentiation of deep layer neurons and increased upper layer neuron generation, and this phenotype was rescued by CB<sub>1</sub> re-expression. Pharmacological regulation with CB<sub>1</sub> receptor agonists or elevation of eCB tone with a monoacylglycerol lipase inhibitor promoted neuronal differentiation of deep layer neurons at the expense of upper layer neurons. Patch-clamp analyses revealed that enhancing cannabinoid signalling facilitated neuronal differentiation and functionality. Noteworthy, incubation with CB<sub>1</sub> receptor agonists during human iPSC-derived cerebral organoid formation also promoted the expansion of BCL11B<sup>+</sup> neurons. These findings unveil a cell-autonomous role of eCB signalling that, <i>via</i> CB<sub>1</sub> receptor, promotes mouse and human deep layer cortical neuron development.</p>
Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors
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Cannabichromene: Integrative modulation of apoptosis, ferroptosis, and endocannabinoid signaling in pancreatic cancer therapy
GEO Series GSE291851. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling
GEO Series GSE249312. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The Crosstalk Between Calcium-sensing Receptor Signaling and Endocannabinoid System in Primary Hyperparathyroidism
ClinicalTrials.gov study NCT03831620. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration
GEO Series GSE36399. Mus musculus. 8 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.