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7 results for “Eonycteris spelaea”
Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea
<p>Bats are reservoir hosts of many zoonotic viruses with pandemic potential in humans. Here, we<br> utilized single-cell transcriptome sequencing (scRNA-seq) to provide detailed comparative<br> analyses of the immune repertoire and the transcriptional responses in the bat lungs upon in<br> vivo infection with a double-stranded RNA virus, Pteropine orthoreovirus PRV3M. Neutrophils<br> were observed to have basally high IDO1 expression, uniquely amongst mammals currently<br> profiled by scRNA-seq. NK/T cells were the most abundant immune cell type in lung tissue, and<br> included three distinct CD8 + effector T cell populations delineated by the differential expression<br> of KLRB1, GFRA2 and DPP4. We identified NK/T clusters which up-regulated genes involved in<br> T-cell activation and effector function early after viral infection. Alveolar macrophages and<br> classical monocytes were key drivers of antiviral interferon signaling. Infection also resulted in<br> the expansion of a CSF1R + population expressing collagen-like genes, which became the<br> predominant myeloid cell type after infection. This work uncovers novel features relevant to viral<br> disease tolerance in bats, lays a foundation for future in vivo and in vitro experimental<br> investigations, and serves as a key resource for comparative immunology studies across bats<br> and other mammals.</p> <p> </p> <p>This upload is the transcriptome fasta file used for alignment for the dataset.</p>
On following pages: 35. Short-palated Fruit Bat (Casinycteris argynnis); 36. Pohle's Fruit Bat (Casinycteris ophiodon); 37. Campo-Ma'an Fruit Bat (Casinycteris campomaanensis); 38. Lesser Dawn Bat (Eonycteris spelaea); 39. Greater Dawn Bat (Eonycteris major); 40. Philippine Dawn Bat (Eonycteris robusta); 41. Geoffroy's Rousette (Rousettus amplexicaudatus): 42. Bare-backed Rousette (Rousettus spinalatus); 43. Leschenault's Rousette (Rousettus leschenaultil); 44. Linduan Rousette (Rousettus linduensis); 45. Sulawesi Rousette (Rousettus celebensis); 46. Egyptian Rousette (Rousettus aegyptiacus); 47 Malagasy Rousette (Rousettus madagascariensis); 48. Comoro Rousette (Rousettus obliviosus); 49. Long-haired Fruit Bat (Stenonycteris lanosus). in Pteropodidae
On following pages: 35. Short-palated Fruit Bat (Casinycteris argynnis); 36. Pohle's Fruit Bat (Casinycteris ophiodon); 37. Campo-Ma'an Fruit Bat (Casinycteris campomaanensis); 38. Lesser Dawn Bat (Eonycteris spelaea); 39. Greater Dawn Bat (Eonycteris major); 40. Philippine Dawn Bat (Eonycteris robusta); 41. Geoffroy's Rousette (Rousettus amplexicaudatus): 42. Bare-backed Rousette (Rousettus spinalatus); 43. Leschenault's Rousette (Rousettus leschenaultil); 44. Linduan Rousette (Rousettus linduensis); 45. Sulawesi Rousette (Rousettus celebensis); 46. Egyptian Rousette (Rousettus aegyptiacus); 47 Malagasy Rousette (Rousettus madagascariensis); 48. Comoro Rousette (Rousettus obliviosus); 49. Long-haired Fruit Bat (Stenonycteris lanosus).
Heat stress response in the cave nectar bat Eonycteris spelaea differs from that of Mus musculus
GEO Series GSE261939. Mus musculus; Eonycteris spelaea. 51 samples. Type: Expression profiling by high throughput sequencing.
Data from: Flight is the key to postprandial blood glucose balance in the fruit bats Eonycteris spelaea and Cynopterus sphinx
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Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea [Bulk RNA-seq]
GEO Series GSE205435. Eonycteris spelaea. 15 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea [scRNA-seq]
GEO Series GSE205768. Eonycteris spelaea. 2 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptome analysis of the in-vivo response to viral infection in the cave nectar bat Eonycteris spelaea
GEO Series GSE205770. Eonycteris spelaea. 17 samples. Type: Expression profiling by high throughput sequencing.
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OpenNeuro
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