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40 results for “Estrous cycle”
Data from: Musashi exerts control of gonadotrope target mRNA translation during the mouse estrous cycle
<p class="MsoNormal">The anterior pituitary controls key biological processes, including growth, metabolism, reproduction and stress responses through distinct cell types that each secrete specific hormones. The anterior pituitary cells show a remarkable level of cell type plasticity that mediates the shifts in hormone producing cell populations that are required to meet organismal needs. The molecular mechanisms underlying pituitary cell plasticity are not well understood. Recent work has implicated the pituitary stem cell populations and specifically, the mRNA binding proteins of the Musashi family in control of pituitary cell type identity. In this study we have identified the target mRNAs that mediate Musashi function in the adult mouse pituitary and demonstrate the requirement for Musashi function <em>in vivo</em>. Using Musashi RNA immunoprecipitation, we identify a cohort of 1184 mRNAs that show specific Musashi binding. Identified Musashi targets include the <em>Gnrhr </em>mRNA, which encodes the gonadotropin releasing hormone receptor (GnRHR), and the <em>Fshb </em>mRNA, encoding <em>follicle-stimulating hormone</em> (FSH). Reporter assays reveal that Musashi functions to exert repression of translation of the <em>Fshb</em> mRNA, in addition to the previously observed repression of the <em>Gnrhr</em>mRNA. Importantly, mice engineered to lack Musashi in gonadotropes demonstrate a failure<em> </em>to repress translation of the endogenous <em>Gnrhr</em> and <em>Fshb</em> mRNAs during the estrous cycle and display a significant heterogeneity in litter sizes. The range of identified target mRNAs suggests that, in addition to these key gonadotrope proteins, Musashi may exert broad regulatory control over the pituitary proteome in a cell-type specific manner.</p>
Data from: Musashi exerts control of gonadotrope target mRNA translation during the mouse estrous cycle
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Neuron soma size and density measurements in male and female adult rat nucleus accumbens shell, nucleus accumbens core, and caudate-putamen disaggregated by sex and estrous cycle phase
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Medium spiny neuron electrophysiological properties across male rats and female rats in different estrous cycle phases in the nucleus accumbens core: Excitatory synaptic input, action potential, and intrinsic properties
<p>This dataset presents electrophysiological properties from whole-cell patch clamped nucleus accumbens core medium spiny neurons from male rats and female rats recorded in different estrous cycle phases. Excitatory synaptic input, action potential, and intrinsic properties are presented in an analyzed format, as well as the original electrophysiological recordings of each neuron. These data were originally presented across two different papers (Proaño et al., 2018, 2020) and further analyzed in an additional paper (Long et al., 2024), all of which are cited below. These data were key for establishing that nucleus accumbens neuron electrical function changed across the estrous cycle in response to its associated hormones, programming a phase-dependent sex difference in adulthood. This finding provided a new framework for understanding how biological sex and hormone cyclicity regulate the neurons implicated in motivated behaviors and related functions and disorders.</p>
Medium spiny neuron electrophysiological properties across male rats and female rats in different estrous cycle phases in the nucleus accumbens core: Excitatory synaptic input, action potential, and intrinsic properties
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The influence of the estrous cycle on sex differences in the rat adult medial prefrontal cortex transcriptome [ChIP-Seq]
GEO Series GSE69772. Rattus norvegicus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene expression profiles in the bovine corpus luteum (CL) of the estrous cycle and pregnancy: Possible roles of chemokines in regulating CL function during pregnancy
GEO Series GSE59770. Bos taurus. 16 samples. Type: Expression profiling by array.
Unexpected nuclear hormone receptor and chromatin dynamics regulate estrous cycle dependent gene expression [RNA-seq]
GEO Series GSE234064. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
The expression pattern of microRNAs in granulosa cells of subordinate and dominant follicles during the early luteal phase of bovine estrous cycle
GEO Series GSE55987. Bos taurus. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Transcriptome profiling of wildtype C57BL/6 female mice during estrous cycle(mainly in estrus and diestrus).
GEO Series GSE131172. Mus musculus. 90 samples. Type: Expression profiling by high throughput sequencing.
Analysis of the mRNA content of bovine oviductal extracellular vesicles during the estrous cycle
GEO Series GSE110399. Bos taurus. 20 samples. Type: Expression profiling by high throughput sequencing.
Estrous cycle influences cell-type-specific translatomic signatures of repeated ketamine exposure in the rat nucleus accumbens
GEO Series GSE303789. Rattus norvegicus. 39 samples. Type: Expression profiling by high throughput sequencing.
Endometrial transcriptome changes in comparison of equine endometrium samples collected on Day 12 of pregnancy and Day 12 of the estrous cycle
GEO Series GSE112237. Equus caballus. 8 samples. Type: Expression profiling by high throughput sequencing.
Unexpected nuclear hormone receptor and chromatin dynamics regulate estrous cycle dependent gene expression [HIF2A cKO RNA-seq]
GEO Series GSE268491. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
The influence of the estrous cycle on sex differences in the rat adult medial prefrontal cortex transcriptome [RNA-Seq]
GEO Series GSE69765. Rattus norvegicus. 11 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA transcriptome profiling in ovarian tissues of pigs with extreme phenotypes for reproductive efficiency during the luteal and follicular phases of the estrous cycle
GEO Series GSE132307. Sus scrofa. 16 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Cell type-specific endometrial transcriptome changes in comparison of equine endometrium samples collected on Day 12 of pregnancy and Day 12 of the estrous cycle
GEO Series GSE112236. Equus caballus. 21 samples. Type: Expression profiling by high throughput sequencing.
Analysis of the small non-coding RNA content of bovine oviductal extracellular vesicles during the estrous cycle
GEO Series GSE110443. Bos taurus. 19 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Exploring the sex and estrous cycle-dependent differences in microglia response to amyloid-beta pathology in female and male C57BL6/J (WT) and 5xFAD using bulk mRNAseq of isolated microglia.
GEO Series GSE306854. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression changes during the estrous cycle in equine endometrium
GEO Series GSE39043. Equus caballus. 25 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.