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4 results for “Ethacrynic acid”
Furosemide Versus Ethacrynic Acid in Children With Congenital Heart Disease
ClinicalTrials.gov study NCT01628731. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Data from: In vitro cytotoxic, antioxidant, hemolytic and cytoprotective potential of promising ethacrynic acid derivatives
<p><span>Female breast cancer is one of the leading causes of death among patients with cancer and requires a proactive strategy for a cure. Triple-negative breast cancer (</span><span>TNBC) is the most aggressive cancer with a high risk of developing metastases. The purpose of the present study was to screen the pharmacological activities of three promising ethacrynic acid (<strong>EA</strong>) derivatives containing a piperazine moiety (<strong>P3</strong>, <strong>P4</strong>, and <strong>P5</strong>). The <strong>EA</strong> derivatives were tested against MDA-MB-468 cancer cell line as a model for TNBC and MCF7 cancer cell line as a model subtype of luminal breast cancer using the methyl tetrazolium test (MTT). Additionally, the modulation of the glutathione and thioredoxin systems, as well as the antioxidant and cytoprotective potential of each compound, were investigated. Moreover, initial in vitro safety screening was conducted using human blood cells. As a result, <strong>EA</strong> derivatives showed clear dose-dependent antiproliferative activity with high selectivity to cancer cells by orchestrating oxidative stress. Derivative <strong>P3</strong> has the most promising potential for further preclinical investigation, owing to its safety profile and significant cytoprotective and antitumor properties</span><span>.</span></p>
Data from: In vitro cytotoxic, antioxidant, hemolytic and cytoprotective potential of promising ethacrynic acid derivatives
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Ethacrynic Acid Elimination in Non-Muscle Invasive Bladder Cancer Patients Undergoing Transurethral Resection
ClinicalTrials.gov study NCT02852564. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.