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Dataset results
18 results for “Extended Spectrum Beta Lactamases”
Data Source file for manuscript: Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients
<p>ABSTRACT</p><p>Infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales (ESBL-PE) are associated with excess morbidity and mortality. Despite recognition of this immediate impact on human health, essential aspects of their molecular epidemiology remain under-investigated. This includes knowledge on the potential of a particular strain to persist in a host, mutational events during colonization, and the genetic diversity in individual patients over time. To investigate long-term genetic diversity of colonizing and infecting ESBL-producing <i>Klebsiella pneumoniae </i>species complex and ESBL-<i>Escherichia coli</i> in individual patients over time, we conducted performed a ten-year longitudinal retrospective study and extracted clinical and microbiological data from electronic health records. In this investigation, 76 ESBL-<i>K. pneumoniae</i> species complex and 284 ESBL-<i>E. coli</i> isolates were recovered from 19 and 61 patients. Strain persistence was detected in all patients colonized with ESBL-<i>K. pneumoniae </i>species complex, and 83.6% of patients colonized with ES BL-<i>E. coli</i>. Antimicrobial resistance genes, plasmid replicons, and whole ESBL-plasmids were shared between isolates regardless of chromosomal relatedness. Our study suggests that patients colonized with ESBL-producers may act as durable reservoirs for ongoing transmission of ESBLs, and that they are at a prolonged risk of recurrent infection with colonizing strains.</p><p>DATA SOURCE FILE</p><p>In this Data Source file, you will find access to the raw data, metadata and results obtained during the study: "Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients". Data is organized following the structure of Figures/Tables of the manuscript and Supplementary Material. Additional figures not included in the main manuscript nor in the Supplementary Material are also available.</p><p>All sequencing and sample data from this study can be accessed at the NCBI database under the BioProject number PRJNA910977: <a href="http://dataview.ncbi.nlm.nih.gov/object/PRJNA910977">http://dataview.ncbi.nlm.nih.gov/object/PRJNA910977. </a>No new software was developed during this study. Standard bioinformatics software was used and the commands used can be accessed at the Supplementary Information file.</p>
Extended Tricyle Project Indonesia for Extended-spectrum Beta-lactamase Positive Klebsiella Pneumoniae and Escherichia Coli
ClinicalTrials.gov study NCT07106944. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
International Travel and the Spread of Extended-spectrum Beta-lactamase-producing Escherichia Coli
ClinicalTrials.gov study NCT01296165. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Ceftolozane/Tazobactam Versus Meropenem for Febrile Neutropenia on Patients Colonized With or at Risk for Infection With Extended Spectrum Beta Lactamase - Producing Pathogens
ClinicalTrials.gov study NCT06342115. IPD Sharing: NO. Countries: 1. Publications: 16.
Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to Extended-spectrum Beta-lactamase (ESBL) or Carbapenemase-producing Enterobacteriaceae: an Observational
ClinicalTrials.gov study NCT01764490. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance
Open the record for dataset details and reuse information.
Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Inten
ClinicalTrials.gov study NCT05565222. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Urinary Tract Infections Caused by Extended-spectrum Beta-lactamase-producing Enterobacteria
ClinicalTrials.gov study NCT06910878. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Association Between Advancing Age and Mortality at 30 Days in Patients With Bacteremia E. Coli Beta-lactamase Phenotype Extended Spectrum RC15_0421
ClinicalTrials.gov study NCT02847065. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Epidemiology of Community - Associated Extended-spectrum Beta-lactamases (ESBL) Producing Escherichia Coli
ClinicalTrials.gov study NCT00573235. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Developing Microbials to Fight Extended-spectrum Beta-lactamase (ESBL)-Producing Escherichia Coli
ClinicalTrials.gov study NCT04764500. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Temocillin Use in Complicated Urinary Tract Infections Due to Extended Spectrum Beta-Lactamases (ESBL)/AmpC Enterobacteriaceae
ClinicalTrials.gov study NCT01543347. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prevalence of Carriage of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacteria in Preterm Premature Rupture of Membranes : A French Multicenter Cohort Study
ClinicalTrials.gov study NCT07200999. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Risk Factors for Piperacillin/Tazobactam Resistance in Extended-Spectrum Beta-Lactamase (ESBL) Producing Organisms
ClinicalTrials.gov study NCT00573521. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Community - Associated Extended-spectrum Beta-lactamases (ESBL)
ClinicalTrials.gov study NCT00363220. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Colonization With Extended-Spectrum Beta-Lactamase (ESBL)-Producing Organisms
ClinicalTrials.gov study NCT01324726. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transcriptional alterations of virulence-associated genes in extended spectrum beta-lactamase (ESBL)-producing uropathogenic Escherichia coli during morphologic transitions induced by ineffective anti
GEO Series GSE99661. Escherichia coli O157:H7 str. Sakai; Escherichia coli CFT073; Escherichia coli str. K-12 substr. MG1655; Escherichia coli; Escherichia coli O157:H7 str. EDL933. 16 samples. Type: Expression profiling by array.
Extended Spectrum Beta Lactamase Producing Organisms In Urinary Tract Infections
ClinicalTrials.gov study NCT05141188. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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