Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
7
datasets available to search
ShareScore release 0.9.0
Dataset results
7 results for “FAM122A”
AlphaFold-Multimer (v3) model of a complex of Protein Phosphatase 2A catalytic subunit (PP2A/C), PP2A scaffold subunit (PP2A/A), the B55alpha substrate binding subunit, and FAM122A, a PP2A inhibitor protein.
<p>AlphaFold-Multimer (v3) model structure of a complex of Protein Phosphatase 2A catalytic subunit (PP2A/C), PP2A scaffold subunit (PP2A/A), the B55alpha substrate binding subunit, and FAM122A, a PP2A inhibitor protein. The protein sequences were obtained from UniProt:</p> <p>P67775 · PP2AA_HUMAN</p> <p>P30153 · 2AAA_HUMAN</p> <p>P63151 · 2ABA_HUMAN</p> <p>Q96E09 · PBIR1_HUMAN</p> <p>Coordinates are in mmCIF format. A PyMOL session file is included.</p> <p>Modeling was performed with AlphaFold-Multimer v3, downloaded from DeepMind's github. Structure prediction was performed without templates. The model was relaxed with Amber.</p> <p>FAM122A binds using a short linear motif (SLIM) (residues 84-89) first identified in RBL1 (p107) (Fowle et al., eLife, <a href="https://doi.org/10.7554/eLife.63181">https://doi.org/10.7554/eLife.63181</a> in the form of a short alpha helix (residues 84-92). This is followed by a long alpha helix (residues 96-122) which blocks access to the active site of the catalytic subunit. There are further contacts of FAM122A (residues 150-170) with one of the beta sheets of the B55alpha beta propeller domain. FAM122A regulates PP2A activity during the cell cycle.</p> <p> </p>
Identification of Fam122a regulated genes in LT-HSCs.
GEO Series GSE151261. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomics analysis of FAM122A knockout and NC K562 cells
GEO Series GSE141735. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
FAM122A is required for mesendodermal and cardiac differentiation of embryonic stem cells [RNA-seq]
GEO Series GSE211234. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
FAM122A is required for mesendodermal and cardiac differentiation of embryonic stem cells
GEO Series GSE211341. Mus musculus. 45 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
FAM122A is required for mesendodermal and cardiac differentiation of embryonic stem cells [ChIP-seq]
GEO Series GSE211235. Mus musculus. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
GEO Series GSE158338. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.