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25 results for “FDA-approved”
Structures of FDA-approved drugs and their active metabolites and data sets of experimental PD and PK properties
<p>Data sets are extracted from the 2024 release of the e-Drug3D Database (2118 FDA-approved drug structures)</p> <ol> <li><strong>e-Drug3D_2118.zip </strong>(contains e-Drug3D_2118.sdf)<strong> -</strong> <strong>Chemical Structures</strong> - The e-Drug3D collection in SDF format file - one 3D conformer; ionization of carboxylic acid, phosphate, phosphonate, phosphonoamide, amidinium and guanidinium groups. The datablock contains the ID, name (INN), CAS number and Status.</li> <li><strong>e-Drug3D_2118_PK.csv - </strong><strong>Pharmacokinetics</strong> - Column/field value is separated by a semicolon. It contains the e-Drug3D ID, INN (drug name), CAS number, year of approval, Status, is_or_has a metabolite, routes of administration, Volume of distribution (VD), Clearance (Cl), Plasma Protein Binding (PPB), Half-life (t1/2), Bioavailability (F), Cmax/Tmax, comment on solubility.</li> <li><strong>e-Drug3D_2118_PD.csv -</strong> <strong>Pharmacodynamics</strong> - Column/field value is separated by a semicolon. It contains the e-Drug3D ID, INN (drug name), CAS number, year of approval, Status, Primary target, ATC code(s), PDB codes and main list of drug targets.</li> <li><strong>e-Drug3D_2118_RD.csv -</strong> <strong>FDA Registration Data</strong> - Column/field value is separated by a semicolon. It contains the ID, name (INN), CAS number, First year of approval, Status, <a href="http://www.knapsackfamily.com/knapsack_core/top.php">KNApSAcK</a> or <a href="https://www.npatlas.org">NPAtlas</a> Id if natural product, all associated NDA numbers [FDA approval number, name of the label file in PDF format, company name, year of approval and commercial name of the drug] and the Indication/Therapeutic class information.</li> <li><strong>labels.tar.gz</strong> - The drug label files in PDF format (compressed directory). A label file is named with the NDA number. The NDA number is the approval number assigned by the FDA. A drug may possess several NDA numbers (see the above e-Drug3D-RD data set).</li> </ol>
Fig. 1 Screening flow, testing 1600 FDA compounds against S in Assessment of FDA-approved drugs against StrongyloideS rAtti in vitro and in vivo to identify potentially active drugs against strongyloidiasis
Fig. 1 Screening flow, testing 1600 FDA compounds against S. ratti
Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD
ClinicalTrials.gov study NCT04220021. IPD Sharing: NO. Countries: 1. Publications: 6.
A Safety and Efficacy Comparison of BLI4700 Bowel Prep Versus an FDA-approved Comparator in Adults Prior to Colonoscopy
ClinicalTrials.gov study NCT03404401. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Study 302: BLI4900 Versus an FDA-approved Comparator in Adult Subjects Prior to Colonoscopy
ClinicalTrials.gov study NCT04446312. IPD Sharing: NO. Countries: 1. Publications: 1.
Supporting Information for Cholinergic Selectivity of FDA-approved and Metabolite Compounds Examined with Molecular Docking-based Virtual Screening
<p><span>Typical docking configurations, detailed docking and visualization results for representative ligands and proteins. </span></p>
Dataset for Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling"
<p>All FDA labels and extraction sheets to support our paper, Desai et al. "Reporting of drug benefit in FDA-approved prescription drug labeling".</p>
Dataset for Kuzucan et al., "Approvals for use in populations specifically excluded from trials supporting FDA-approved antibiotics, 1999-2018"
<p>Extraction sheet for Kuzucan et al., "Approvals for use in populations specifically excluded from trials supporting FDA-approved antibiotics, 1999-2018" (citation forthcoming)</p>
Metal Ion Release From an FDA-Approved Metal-on-Metal Total Hip Replacement Implant
ClinicalTrials.gov study NCT00962351. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A New Tablet Containing Two FDA-Approved Drugs In HIV-Infected Patients Who Have Not Received Prior Therapy
ClinicalTrials.gov study NCT00053638. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Water networks in complexes between proteins and FDA-approved drugs
<p>Dataset to accompany manuscript - prepared protein-ligand complexes</p>
A Safety and Efficacy Comparison of BLI4700 Bowel Preparation Versus an FDA-approved Comparator in Adult Subjects Prior to Colonoscopy
ClinicalTrials.gov study NCT03261960. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Study 301: BLI4900 Versus an FDA-approved Comparator in Adult Subjects Prior to Colonoscopy
ClinicalTrials.gov study NCT04446299. IPD Sharing: NO. Countries: 1. Publications: 0.
Breast cancer cell lines treated with mebedazole (an FDA-approved anti-parasitic) under 20% or 1% oxygen conditions.
GEO Series GSE222702. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Phase 1 Study of the Effects of Combining Topical FDA-approved Drugs on Age-related Pathways on the Skin of Healthy Volunteers
ClinicalTrials.gov study NCT03072485. IPD Sharing: NO. Countries: 1. Publications: 0.
A Pilot Study of Total-body PET Using FDA-approved Radiotracers Beyond 18F-FDG
ClinicalTrials.gov study NCT05160480. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs
ClinicalTrials.gov study NCT06933056. IPD Sharing: NO. Countries: 1. Publications: 0.
Study Of An FDA-approved Drug As Additional Therapy In Patients With Schizophrenia
ClinicalTrials.gov study NCT00086593. IPD Sharing: YES. Countries: 3. Publications: 0.
Triple-negative breast cancer cell lines treated with mebedazole (an FDA-approved anti-parasitic).
GEO Series GSE190845. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.
GEO Series GSE99116. Homo sapiens. 120 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
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International Brain Laboratory public data
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OpenNeuro
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