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45 results for “FOCAL SEIZURES”
dataset related to article "Seizure activity and brain damage in a model of focal non-convulsive status epilepticus"
<p>Excell files with the values used on the construction of the graphical illustrations for the publication</p>
Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness
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Data from: Thalamus and focal to bilateral seizures: a multi-scale cognitive imaging study
<p><span><span><span><span><span><span><span><span><span><span><span><b><i>Objective</i></b></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>To investigate the functional correlates of recurrent secondarily generalized seizures in temporal lobe epilepsy (TLE), using task-based fMRI as a framework to test for epilepsy-specific network rearrangements. As the thalamus modulates propagation of temporal-lobe onset seizures and promotes cortical synchronization during cognition, we hypothesized that occurrence of secondarily generalized, i.e. focal to bilateral tonic-clonic seizures (FBTCS), would relate to thalamic dysfunction, altered connectivity and whole-brain network centrality.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b><i>Methods</i></b></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>FBTCS occur in a third of patients with TLE and are a major determinant of disease severity. In this cross-sectional study, we analyzed 113 patients with drug-resistant TLE (55 left/58 right), who performed a verbal fluency fMRI task that elicited robust thalamic activation. Thirty-three patients (29%) had experienced at least one FBTCS in the year preceding the investigation. We compared patients with TLE-FBTCS to those without FBTCS via a multi-scale approach, entailing analysis of SPM12-derived measures of activation, task-modulated thalamic functional connectivity (psychophysiological interaction), and graph-theoretical metrics of centrality. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b><i>Results</i></b></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>Individuals with TLE-FBTCS had less task-related activation of bilateral thalamus, with left-sided emphasis, and left hippocampus than those without FBTCS. In TLE-FBTCS, we also found greater task-related thalamotemporal and thalamo-motor connectivity, and higher thalamic degree and betweenness centrality. Receiver operating characteristic curves, based on a combined thalamic functional marker, accurately discriminated individuals with and without FBTCS.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b><i>Conclusions</i></b></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>In TLE-FBTCS, impaired task-related thalamic recruitment coexists with enhanced thalamotemporal connectivity and whole-brain thalamic network embedding. Altered thalamic functional profiles are proposed as imaging biomarkers of active secondary generalization.</span></span></span></span></span></span></span></span></span></span></span></p>
Data: Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy
<p>We make available all the brain network data, and metadata of 83 patients and 29 healthy controls included in our study.</p> <p>Nishant Sinha, Natalie Peternell, Gabrielle M. Schroeder, Jane de Tisi, Sjoerd B. Vos, Gavin P. Winston, John S. Duncan, Yujiang Wang, and Peter N. Taylor "<em>Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy.</em>" Epilepsia 2021 <em>doi:10.1111/epi.16819</em>.</p> <p>Methodological details on MRI acquisition and data processing are provided in our manuscript. We request users to kindly cite our article and data appropriately.</p>
Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
ClinicalTrials.gov study NCT03373383. IPD Sharing: YES. Countries: 19. Publications: 2.
A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures
ClinicalTrials.gov study NCT04244175. IPD Sharing: NO. Countries: 7. Publications: 1.
A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy
ClinicalTrials.gov study NCT03739840. IPD Sharing: YES. Countries: 28. Publications: 1.
Focal Electrically-Administered Seizure Therapy (FEAST) Studies at Two Enrolling Sites to Further Test and Refine the Treatment
ClinicalTrials.gov study NCT02535572. IPD Sharing: Not stated. Countries: 1. Publications: 2.
An Open-label Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures
ClinicalTrials.gov study NCT04686786. IPD Sharing: NO. Countries: 7. Publications: 1.
Data from: Thalamus and focal to bilateral seizures: a multi-scale cognitive imaging study
Open the record for dataset details and reuse information.
Supplementary code and visualisations for "Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy"
<p>MATLAB code and workspaces for reproducing the main results and figures of the paper "Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy." Additional supplementary visualisations for all patients are also provided as PDFs. </p> <p>The paper preprint is available on bioRxiv: https://www.biorxiv.org/content/10.1101/661371v2</p>
A Study of GWP42006 in People With Focal Seizures - Part B
ClinicalTrials.gov study NCT02365610. IPD Sharing: Not stated. Countries: 6. Publications: 1.
EpiCare@Home Validation Study for Focal Onset Seizures
ClinicalTrials.gov study NCT05738226. IPD Sharing: NO. Countries: 1. Publications: 5.
Cenobamate in Adults With Focal-Onset Seizures
ClinicalTrials.gov study NCT05859854. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Focal Electrically Administered Seizure Therapy for the Treatment of Depression
ClinicalTrials.gov study NCT02462551. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Effect of Carbamazepine and Oxcarbazepine on Serum Neuron-specific Enolase and S100B in Focal Seizures
ClinicalTrials.gov study NCT02705768. IPD Sharing: NO. Countries: 1. Publications: 15.
A Study Investigating the Anti-epileptic Efficacy of Afinitor (Everolimus) in Patients With Refractory Seizures Who Have Focal Cortical Dysplasia Type II (FCD II)
ClinicalTrials.gov study NCT03198949. IPD Sharing: NO. Countries: 1. Publications: 1.
Forecasting seizure risk in adults with focal epilepsy: a development and validation study - Data
<p><strong>Data for the article 'Forecasting seizure risk in adults with focal epilepsy: a development and validation study'</strong></p> <p>Includes deidentified individual data in the form of interictal epileptiform activity counts and electrographic seizures for the 18 patients in the development cohort.</p>
A Study of Perampanel as Add-on Therapy in Adult and Adolescent Participants With Focal Seizures
ClinicalTrials.gov study NCT04257604. IPD Sharing: YES. Countries: 0. Publications: 0.
Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy
ClinicalTrials.gov study NCT04650204. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.