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Dataset results
201 results for “FOLFOX”
Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
<p>The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed an increased phosphorylation of AKT1/mTOR/4EBP1 and levels of p21 in FOLFOX-resistant CRC cells. We have identified a small molecule, NSC49L, that stimulates protein phosphatase 2A (PP2A) activity, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. We have provided evidence that NSC49L- and TRAIL-mediated sensitization is synergistically induced in p21-knockdown CRC cells, which is reversed in p21-overexpressing cells. p21 binds with procaspase 3 and prevents activation of caspase 3. We have shown that TRAIL induces apoptosis through the activation of caspase 3 by NSC49L-mediated downregulation of p21 translation, and thereby cleavage of procaspase 3 into caspase 3. NSC49L does not affect global protein synthesis. These studies provide a mechanistic understanding of NSC49L as a PP2A agonist, and how its combination with TRAIL sensitizes FOLFOX-resistant CRC cells.</p>
Randomized Study Of Sunitinib Plus FOLFOX Versus Bevacizumab Plus FOLFOX In Metastatic Colorectal Cancer
ClinicalTrials.gov study NCT00609622. IPD Sharing: Not stated. Countries: 4. Publications: 2.
Pre- and Post-operative FOLFOX Based Therapy for Patients With Colorectal Cancer With Liver Involvement
ClinicalTrials.gov study NCT00537823. IPD Sharing: Not stated. Countries: 1. Publications: 30.
A Trial to Compare Oxaliplatin, Folinic Acid (FA) and 5-Fluorouracil (5FU) Combination Chemotherapy (FOLFOX-4) With or Without Cetuximab in the 1st Line Treatment of Metastatic Colorectal Cancer (mCRC
ClinicalTrials.gov study NCT01228734. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study of Nivolumab Combined With FOLFOX and Regorafenib in People Who Have HER2-Negative Esophagogastric Cancer
ClinicalTrials.gov study NCT04757363. IPD Sharing: YES. Countries: 1. Publications: 1.
Study to Evaluate the Efficacy and Safety of FOLFOX-4 Plus Cetuximab Versus UFOX Plus Cetuximab.
ClinicalTrials.gov study NCT00439517. IPD Sharing: Not stated. Countries: 14. Publications: 1.
FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal Cancer
ClinicalTrials.gov study NCT00724503. IPD Sharing: Not stated. Countries: 11. Publications: 5.
First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX
ClinicalTrials.gov study NCT00384176. IPD Sharing: Not stated. Countries: 28. Publications: 3.
Intra-arterial Hepatic Beads Loaded With Irinotecan With Concomitant Chemotherapy With FOLFOX in Patients With Colorectal Cancer With Unresectable Liver Metastases: a Phase II Multicenter Study
ClinicalTrials.gov study NCT01839877. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Pegilodecakin (LY3500518) With FOLFOX Compared to FOLFOX Alone Second-line Tx in Participants With Metastatic Pancreatic Cancer
ClinicalTrials.gov study NCT02923921. IPD Sharing: YES. Countries: 13. Publications: 1.
Clinical Trial of a Novel Dose Adjustment Algorithm for Preventing Cytopenia-Related Delays During FOLFOX Chemotherapy
ClinicalTrials.gov study NCT04526886. IPD Sharing: NO. Countries: 1. Publications: 2.
RAD001, FOLFOX and Bevacizumab in Treatment of Colorectal Carcinoma
ClinicalTrials.gov study NCT01047293. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Adjuvant Therapy(3 vs. 6 Months) With the FOLFOX 4 or XELOX for Stage II or Stage III Colon Cancer
ClinicalTrials.gov study NCT01308086. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Randomized Phase II Study of FOLFOX Versus FOLFIRI.3 in Gemcitabine-refractory Pancreatic Cancer
ClinicalTrials.gov study NCT00786006. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Investigating the Role of Oxaliplatin Duration in Modified FOLFOX-6 or CAPOX Regimen as Adjuvant Colon Cancer Therapy
ClinicalTrials.gov study NCT01092481. IPD Sharing: Not stated. Countries: 1. Publications: 1.
FOLFIRI or FOLFOX With or Without Cetuximab in Patients With Metastatic Adenocarcinoma of the Colon or Rectum
ClinicalTrials.gov study NCT00077233. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Hepatic Arterial Infusion of Raltetrexed With Oxaliplatin(SALOX) Versus FOLFOX in Advanced Hepatocellular Carcinoma
ClinicalTrials.gov study NCT05231382. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Camrelizumab Combined With FOLFOX Neoadjuvant Therapy for Resectable Gastric and Gastroesophageal Junctional Adenocarcinoma
ClinicalTrials.gov study NCT03939962. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of the Safety and the Tolerability of Durvalumab Plus Tremelimumab Combined With FOLFOX in mCRC
ClinicalTrials.gov study NCT03202758. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Adjuvant Chemotherapy With FOLFOX in HCC Patients After Resection
ClinicalTrials.gov study NCT02738697. IPD Sharing: NO. Countries: 1. Publications: 5.
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